Processes, apparatuses, and systems for the production, separation and purification of radioisotopes for medical, industrial, agricultural, and energy applications are disclosed. The following operations are performed: selective adsorption of at least one radionuclide to a solid support and desorption of the at least one absorbed radionuclide by evaporation; or electrochemical separation of the at least one radionuclide by electrochemically depositing either the at least one radionuclide or the target material on a metallic electrode; or removing the target material by high temperature sublimation under vacuum or in an inert atmosphere, if the at least one radionuclide is less volatile than the target material.