A device for tangential flow filtration includes a filter unit having first and second fluid openings, a filter element and a permeate opening, a first flow connection to connect the first fluid opening to a reservoir, a second flow connection to connect the second fluid opening to the reservoir, a first centrifugal pump in the first flow connection to convey the fluid from the reservoir to the filter unit, a first controller to actuate the first centrifugal pump, the filter unit designed such that the fluid for tangential flow filtration is capable of flowing substantially parallel to the filter element, a second centrifugal pump in the second flow connection, with which a counter-pressure is capable of being generated at the second fluid opening, and a second controller to actuate the second centrifugal pump.

A dialyzer (15) includes a hollow fiber dialysis column (20), a liquid tubing section (12a), and a flow rate changing section (16a). The hollow fiber dialysis column (20) includes a hollow fiber membrane, a first flow channel that allows a dialysis target to flow internally of the hollow fiber membrane, and a second flow channel that allows an external liquid to flow externally of the hollow fiber membrane. The liquid tubing section (12a) tubes the dialysis target to an inlet (20a) of the first flow channel. The flow rate changing section (16a) is capable of changing a flow rate of the dialysis target at the dialysis target flowing out of an outlet (20b) of the first flow channel.

A dialyzer (15) includes a hollow fiber dialysis column (20), a liquid tubing section (12a), and a flow rate changing section (16a). The hollow fiber dialysis column (20) includes a hollow fiber membrane, a first flow channel that allows a dialysis target to flow internally of the hollow fiber membrane, and a second flow channel that allows an external liquid to flow externally of the hollow fiber membrane. The liquid tubing section (12a) tubes the dialysis target to an inlet (20a) of the first flow channel. The flow rate changing section (16a) is capable of changing a flow rate of the dialysis target at the dialysis target flowing out of an outlet (20b) of the first flow channel.

Systems and methods for filtering materials from biologic fluids are discussed. Embodiments may be used to filter cerebrospinal fluid (CSF) from a human or animal subject. In an example, CSF is separated into a permeate and retentate using a tangential flow filter. The retentate is filtered again and then returned to the subject with the permeate. During operation of the system, various parameters may be modified, such as flow rate and waste rate.

The present invention provides a method for producing lipid particles that have a desired particle diameter, the method comprising: (A) a step for preparing, in a first mixing region, a primary dilution by mixing a first solution containing a lipid and an alcohol with a second solution containing water; (B) a step for feeding the primary dilution from the first mixing region to a second mixing region through a liquid feed pipe within a prescribed time; and (C) a step for preparing a secondary dilution by mixing the primary dilution with a third solution containing water in the second mixing region, wherein the steps (A)-(C) are continuously carried out, and the particle diameter of the lipid particles is controlled by adjusting at least one condition selected from the group consisting of the concentration of the alcohol and the concentration of the lipid in the primary dilution, the prescribed time, and the temperature during mixing.

The present invention provides a method for producing lipid particles that have a desired particle diameter, the method comprising: (A) a step for preparing, in a first mixing region, a primary dilution by mixing a first solution containing a lipid and an alcohol with a second solution containing water; (B) a step for feeding the primary dilution from the first mixing region to a second mixing region through a liquid feed pipe within a prescribed time; and (C) a step for preparing a secondary dilution by mixing the primary dilution with a third solution containing water in the second mixing region, wherein the steps (A)-(C) are continuously carried out, and the particle diameter of the lipid particles is controlled by adjusting at least one condition selected from the group consisting of the concentration of the alcohol and the concentration of the lipid in the primary dilution, the prescribed time, and the temperature during mixing.

A medical monitoring device for monitoring electrical signals from the body of a subject is described. The medical monitoring device monitors electrical signals originating from a cardiac cycle of the subject and associates each cardiac cycle with a time index. The medical monitoring device applies a forward computational procedure to generate a risk score indicative of hyperkalemia, hypokalemia or arrhythmia of the subject. The medical monitoring device can adjust the forward computational procedure based upon clinical data obtained from the subject.

A medical monitoring device for monitoring electrical signals from the body of a subject is described. The medical monitoring device monitors electrical signals originating from a cardiac cycle of the subject and associates each cardiac cycle with a time index. The medical monitoring device applies a forward computational procedure to generate a risk score indicative of hyperkalemia, hypokalemia or arrhythmia of the subject. The medical monitoring device can adjust the forward computational procedure based upon clinical data obtained from the subject.

Systems and methods for filtering materials from biologic fluids are discussed. Embodiments may be used to filter cerebrospinal fluid (CSF) from a human or animal subject. In an example, CSF is separated into a permeate and retentate using a tangential flow filter. The retentate is filtered again and then returned to the subject with the permeate. During operation of the system, various parameters may be modified, such as flow rate and waste rate.

Systems and methods for filtering materials from biologic fluids are discussed. Embodiments may be used to filter cerebrospinal fluid (CSF) from a human or animal subject. In an example, CSF is separated into a permeate and retentate using a tangential flow filter. The retentate is filtered again and then returned to the subject with the permeate. During operation of the system, various parameters may be modified, such as flow rate and waste rate.