The invention relates to a blood treatment device configured to dephosphorylate extracellular adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP) and/or lipopolysaccharide (LPS) in the blood of a patient in need thereof in an extracorporeal blood circuit, wherein the device comprises a matrix having alkaline phosphatase (AP) immobilized thereon. The invention further relates to an extracorporeal blood circuit comprising a blood treatment device of the invention and to the blood treatment device for use as a medicament or to methods of treating an infection, preferably a blood or systemic infection, such as sepsis, and/or for the treatment of sepsis-associated acute kidney injury (AKI).

Described herein are fluid treatment devices for use in tangential flow filtration, comprising a housing unit and a composite material, wherein the composite material comprises: a support member comprising a plurality of pores extending through the support member; and a non-self-supporting macroporous cross-linked gel comprising macropores having an average size of 10 nm to 3000 nm, said macroporous gel being located in the pores of the support member. The invention also relates to a method of separating a substance from a fluid, comprising the step of placing the fluid in contact with an inventive device, thereby adsorbing or absorbing the substance to the composite material contained therein.

Described herein are fluid treatment devices for use in tangential flow filtration, comprising a housing unit and a composite material, wherein the composite material comprises: a support member comprising a plurality of pores extending through the support member; and a non-self-supporting macroporous cross-linked gel comprising macropores having an average size of 10 nm to 3000 nm, said macroporous gel being located in the pores of the support member. The invention also relates to a method of separating a substance from a fluid, comprising the step of placing the fluid in contact with an inventive device, thereby adsorbing or absorbing the substance to the composite material contained therein.

Dialyzer systems can consolidate multiple technologies and functionalities of blood treatment systems in a significantly integrated fashion. For example, this disclosure describes dialyzer systems that include a magnetically driven and magnetically levitating pump rotor integrated into the dialyzer. Such a dialyzer can be used with treatment modules that include a magnetic field-generating pump drive unit. In some embodiments, the dialyzers include pressure sensor chambers with flexible membranes with which corresponding pressure transducers of the treatment modules can interface to detect arterial and/or venous pressures.

Disclosed herein is a high efficiency filtration device and a method thereof for analysis of a fluid sample to detect the presence of target pathogens or indicator microorganisms. Also disclosed herein is a kit to detect the presence of target pathogens or indicator microorganisms, comprising the disclosed filtration device and a molecular detection device. Also disclosed herein is a hardware mobile electronic device and a software application that analyze a fluid sample to detect the presence of target pathogens or indicator microorganisms and wirelessly transmits such information to users.

Described herein are fluid treatment devices for use in tangential flow filtration, comprising a housing unit and a composite material, wherein the composite material comprises: a support member comprising a plurality of pores extending through the support member; and a non-self-supporting macroporous cross-linked gel comprising macropores having an average size of 10 nm to 3000 nm, said macroporous gel being located in the pores of the support member. The invention also relates to a method of separating a substance from a fluid, comprising the step of placing the fluid in contact with an inventive device, thereby adsorbing or absorbing the substance to the composite material contained therein.

A membrane contactor for degassing a gas-entrained liquid and to discharge gas-depleted liquid includes: a shell has two ends; a cap closes one shell end; a membrane extends between the shell ends and is enclosed within the shell; a first center tube discharges the gas-entrained liquid into the membrane; a second center tube discharges the gas-depleted liquid from the contactor; and one tube surrounds the other tube. The membrane may be a flat sheet membrane or a hollow fiber membrane. The cap has an in let in fluid communication with the first center tube and an outlet in fluid communication with the second center tube. A baffle may be located within the membrane between the shell ends.

Disclosed herein is a single pass cross flow filtration system comprising: a filtration module comprising two or more filtration segments fluidly connected in series, each having an upstream side and a downstream side; wherein each filtration segment comprises hollow fiber filter membranes, and wherein, when in use, the desired permeate flux is controlled by a configuration comprising; each filtration segment having a selected length; the hollow fiber filter membranes of each filtration segment having a selected inner diameter, wherein the selected inner diameters may be the same or different, provided that at least one of the selected inner diameters differs from the others, and provided that the two or more filtration segments are arranged such that no inner diameter is larger on the upstream side; and one or more pumps, mounted in the permeate channel.

Described herein are fluid treatment devices for use in tangential flow filtration, comprising a housing unit and a composite material, wherein the composite material comprises: a support member comprising a plurality of pores extending through the support member; and a non-self-supporting macroporous cross-linked gel comprising macropores having an average size of 10 nm to 3000 nm, said macroporous gel being located in the pores of the support member. The invention also relates to a method of separating a substance from a fluid, comprising the step of placing the fluid in contact with an inventive device, thereby adsorbing or absorbing the substance to the composite material contained therein.

There is disclosed a process and apparatus for treating urine. Urine is contained in a reservoir and contacted with a liquid side of a separation membrane which also has a gas side. A sweep gas flow is generated on the gas side of the separation membrane. Water in the urine is conducted from the liquid side to the gas flow side of the separation membrane, the separation membrane substantially preventing the passage of other components of urine from the liquid side to the gas flow side of the separation membrane. The water conducted to the gas flow side of the separation membrane is entrained in the sweep gas flow.