A method for reducing a contaminating DNA content of a preparation containing AAV capsids and contaminating DNA, comprising the steps of a) Performing an extraction of DNA with a solid phase bearing positive charges at its surface said solid phase is contacted with the preparation at a pH of 7.0±1.0, and a salt concentration of 10 mM to 200 mM yielding a first fraction, (b) Diafiltering the first fraction by a first tangential flow filtration to obtain a second fraction, (c) Treating the second fraction with DNase, (d) Diafiltering the DNase treated second fraction obtained by step c) by a second tangential flow, (e) filtration to a buffer with pH of 7.0±1.0, and a salt concentration of 10 mM to 20 mM to yield a third fraction, and optionally (f) Concentrating the third fraction by tangential flow filtration before supplemental chromatography.

An external circulation-type hollow fiber membrane module which has a high processing capacity and which is capable of inhibiting a to-be-treated liquid within a case from flowing through a short path and efficiently bringing the liquid into contact with a hollow fiber membrane in whichever direction of a vertical direction, a horizontal direction, etc., the liquid flows. An external circulation-type hollow fiber membrane module is provided with: a hollow fiber membrane bundle; a case; and a short-path prevention body that blocks flowing of a to-be-treated liquid in a gap between the hollow fiber membrane bundle and the case, wherein a first end of the hollow fiber membrane bundle is fixed in the case, and the short-path prevention body is provided to the downstream side of a first port which is a liquid flow-in port in the case so as to project from the inner surface of the case.

A ceramic filter membrane module enables a fluid to be filtered, such as raw water, with higher efficiency using multiple ceramic filters in a housing. As the diameter of a through-hole located at the center is considerably larger than the diameter of the surrounding flow path, water pressure pushing the raw water is applied from the through-hole at the center toward the outside of a filter body, such that the raw water passes through the filter body smoothly, thereby improving the purification efficiency and uniformly setting the overall flow direction of the raw water. As packing members are installed and fixed between the housing and the ceramic filters, sealing of the incoming raw water and the filtered water becomes more effective, such that the risk of leakage is reduced. As a plurality of ceramic filters are housed in a single housing, economic benefit can be achieved.

Exemplary embodiments in desalination by direct contact membrane distillation present a cylindrical cross-flow module containing high-flux composite hydrophobic hollow fiber membranes. The present embodiments are directed to a model that has been developed to describe the observed water production rates of such devices in multiple brine feed introduction configurations. The model describes the observed water vapor production rates for different feed brine temperatures at various feed brine flow rates. The model flux predictions have been explored over a range of hollow fiber lengths to compare the present results with those obtained earlier from rectangular modules which had significantly shorter hollow fibers.

Exemplary embodiments in desalination by direct contact membrane distillation present a cylindrical cross-flow module containing high-flux composite hydrophobic hollow fiber membranes. The present embodiments are directed to a model that has been developed to describe the observed water production rates of such devices in multiple brine feed introduction configurations. The model describes the observed water vapor production rates for different feed brine temperatures at various feed brine flow rates. The model flux predictions have been explored over a range of hollow fiber lengths to compare the present results with those obtained earlier from rectangular modules which had significantly shorter hollow fibers.

A membrane assembly includes a tube container having an inlet conduit and a first outlet conduit both oriented in a radial direction, and a second outlet conduit oriented in an axial direction; and a hollow fiber membrane element disposed inside the tube container, the hollow first membrane element comprising a first adapter with an axial permeate fluid passage in a center thereof and an inlet gas passage in a peripheral portion thereof; and a second adapter with an axial permeate fluid passage in a center thereof and a non-permeate fluid passage in a peripheral portion thereof.

A membrane assembly includes a tube container having an inlet conduit and a first outlet conduit both oriented in a radial direction, and a second outlet conduit oriented in an axial direction; and a hollow fiber membrane element disposed inside the tube container, the hollow first membrane element comprising a first adapter with an axial permeate fluid passage in a center thereof and an inlet gas passage in a peripheral portion thereof; and a second adapter with an axial permeate fluid passage in a center thereof and a non-permeate fluid passage in a peripheral portion thereof.

Water or wastewater filtration processes and systems have a plurality of membrane modules, each having filter media therein, the plurality of membrane modules arranged in parallel fluid flow, a main bottom feed conduit, a main top feed conduit, and separate feed conduits fluidly connecting the main bottom feed conduits and the main top feed conduits to respective membrane modules. A main filtrate conduit, and separate filtrate conduits fluidly connect respective membrane modules to the main filtrate conduit. A backwash conduit fluidly connects the main filtrate conduit to respective membrane modules through the main top and bottom feed conduits. A pump having a pump feed conduit and a pump discharge conduit, the pump discharge conduit fluidly connected to the main top and bottom feed conduits, and a plurality of automatically controllable valves positioned in the main top and bottom feed conduits, the main filtrate conduit, the pump discharge conduit, and the backwash conduit, with a controller configured to actuate the plurality of automatically controllable valves to control feed and backwash flows through the membrane modules using pressure developed only by the pump. The pump is preferably operated by a variable-speed prime mover.

The filter module case includes a casing, a cap, a first layer, and a second layer. The casing has a cylindrical shape. The cap has a cylindrical shape and defines a passage providing communication between the inside and the outside of the casing and receives an end portion of the casing and is bonded to the casing. The first layer is closer to an end and faces an outer peripheral surface of the casing and the inner wall surface of the cap. The second layer is closer to the center and faces the outer peripheral surface of the casing and the inner wall surface of the cap. The casing and the cap have organic solvent resistance. The first layer is formed of a first adhesive with organic solvent resistance. The second layer is formed of a second adhesive that has an affinity for hard-to-adhere materials and has a higher elasticity.

The filter module case includes a casing, a cap, a first layer, and a second layer. The casing has a cylindrical shape. The cap has a cylindrical shape and defines a passage providing communication between the inside and the outside of the casing and receives an end portion of the casing and is bonded to the casing. The first layer is closer to an end and faces an outer peripheral surface of the casing and the inner wall surface of the cap. The second layer is closer to the center and faces the outer peripheral surface of the casing and the inner wall surface of the cap. The casing and the cap have organic solvent resistance. The first layer is formed of a first adhesive with organic solvent resistance. The second layer is formed of a second adhesive that has an affinity for hard-to-adhere materials and has a higher elasticity.