A subsea fluid processing system which receives a wellstream flow. The subsea fluid processing system includes a pressure control device which regulates a pressure of the wellstream flow, a gas-liquid separator unit which receives the wellstream flow downstream of the pressure control device and which provides a liquid stream and a gas stream, a first membrane separator which receives the gas stream and which provides a retentate stream and a permeate stream, a compressor which receives the permeate stream and which provides a compressed permeate stream, and a discharge cooler which receives the compressed permeate stream and which provides a cooled compressed permeate stream for injection into a subsurface reservoir. A density of the cooled compressed permeate stream is higher than a density of the compressed permeate stream.

An oxygenator having a plurality of porous hollow fiber membranes for gas exchange to treat blood is manufactured by dissolving a silicone compound in an organic solvent having a surface tension of less than 70 dyn/cm to prepare a coating solution, and bringing an inner surface of the hollow fiber membranes into contact with the coating solution under a negative pressure of 50 hPa or more and 150 hPa or less to form a silicone compound-containing coating layer on the inner surface. An antithrombotic polymer compound-containing coat can be provided directly on an outer surface of the hollow fiber membranes.

An oxygenator having a plurality of porous hollow fiber membranes for gas exchange to treat blood is manufactured by dissolving a silicone compound in an organic solvent having a surface tension of less than 70 dyn/cm to prepare a coating solution, and bringing an inner surface of the hollow fiber membranes into contact with the coating solution under a negative pressure of 50 hPa or more and 150 hPa or less to form a silicone compound-containing coating layer on the inner surface. An antithrombotic polymer compound-containing coat can be provided directly on an outer surface of the hollow fiber membranes.

The present invention addresses to a high-pressure vessel for packaging hollow fiber type membranes with application in the field of separation process with contactors with membranes aiming at a compact device/piece of equipment configured for the packaging of hollow fiber type bundles that can be used for various fluid separation processes such as liquid-liquid, liquid-gas and gas-gas, capable of working at high-pressures, enabling adequate hydrodynamic conditions and easily scalable. It is called a module the general piece of equipment, consisting of the vessel (A or C), object of the present invention, and the membranes packed inside the vessel. This piece of equipment consists of a vessel inside which the membranes are placed (14), and two heads attached at the ends (B or D). Each head has two connection points, thus allowing this device to be used with membrane contactors-type separation systems, such as “classical” permeation systems (liquid-liquid, gas-gas, pervaporation).

The present invention addresses to a high-pressure vessel for packaging hollow fiber type membranes with application in the field of separation process with contactors with membranes aiming at a compact device/piece of equipment configured for the packaging of hollow fiber type bundles that can be used for various fluid separation processes such as liquid-liquid, liquid-gas and gas-gas, capable of working at high-pressures, enabling adequate hydrodynamic conditions and easily scalable. It is called a module the general piece of equipment, consisting of the vessel (A or C), object of the present invention, and the membranes packed inside the vessel. This piece of equipment consists of a vessel inside which the membranes are placed (14), and two heads attached at the ends (B or D). Each head has two connection points, thus allowing this device to be used with membrane contactors-type separation systems, such as “classical” permeation systems (liquid-liquid, gas-gas, pervaporation).

A hollow fiber membrane module (100) of the present disclosure includes: a plurality of hollow fiber membranes (10); a binding portion (20) binding the plurality of hollow fiber membranes (10) at one end portions thereof; and a cap (30) having an internal space (30s) that communicates with each of the plurality of hollow fiber membranes (10), the cap (30) being integrated with the binding portion (20). Specifically, no other component is present between the binding portion (20) and the cap (30).

A hollow fiber membrane module (100) of the present disclosure includes: a plurality of hollow fiber membranes (10); a binding portion (20) binding the plurality of hollow fiber membranes (10) at one end portions thereof; and a cap (30) having an internal space (30s) that communicates with each of the plurality of hollow fiber membranes (10), the cap (30) being integrated with the binding portion (20). Specifically, no other component is present between the binding portion (20) and the cap (30).

A hollow fiber membrane module includes a pressure vessel, a plurality of hollow fiber membrane elements arranged in series inside the pressure vessel, and a connector that connects the hollow fiber membrane elements to each other. Each of the hollow fiber membrane elements includes a plurality of hollow fiber membranes, and a double-core tube extending in a longitudinal direction of the plurality of hollow fiber membrane elements. The connector includes a first channel and a second channel that do not communicate with each other. Between the hollow fiber membrane elements, the outer channels of the hollow fiber membrane elements are connected to each other through the first channel, the inner channels of the hollow fiber membrane elements are connected to each other through the second channel, and hollow portions of the hollow fiber membranes communicate with the inner channels through the second channel.

A hollow fiber membrane module includes a pressure vessel, a plurality of hollow fiber membrane elements arranged in series inside the pressure vessel, and a connector that connects the hollow fiber membrane elements to each other. Each of the hollow fiber membrane elements includes a plurality of hollow fiber membranes, and a double-core tube extending in a longitudinal direction of the plurality of hollow fiber membrane elements. The connector includes a first channel and a second channel that do not communicate with each other. Between the hollow fiber membrane elements, the outer channels of the hollow fiber membrane elements are connected to each other through the first channel, the inner channels of the hollow fiber membrane elements are connected to each other through the second channel, and hollow portions of the hollow fiber membranes communicate with the inner channels through the second channel.

A method for reducing a contaminating DNA content of a preparation containing AAV capsids and contaminating DNA, comprising the steps of a) Performing an extraction of DNA with a solid phase bearing positive charges at its surface said solid phase is contacted with the preparation at a pH of 7.0±1.0, and a salt concentration of 10 mM to 200 mM yielding a first fraction, (b) Diafiltering the first fraction by a first tangential flow filtration to obtain a second fraction, (c) Treating the second fraction with DNase, (d) Diafiltering the DNase treated second fraction obtained by step c) by a second tangential flow, (e) filtration to a buffer with pH of 7.0±1.0, and a salt concentration of 10 mM to 20 mM to yield a third fraction, and optionally (f) Concentrating the third fraction by tangential flow filtration before supplemental chromatography.