Stacked-plate filters may include a plurality of stacked filter plates with small gaps therebetween. The present disclosure provides a stacked-plate filter apparatus comprising a plurality of filter plates stacked along a longitudinal axis with the filter plates substantially parallel. Each filter plate has a respective outer rim, first face and second face. Each of the filter plates defines a respective opening therethrough. The outer rim forms a first peripheral edge at the first face and a second peripheral edge at the second face. The first peripheral edge is radially misaligned from the second peripheral edge to form an offset gap interface for each adjacent pair of the filter plates. For each of the filter plates, the respective outer rim may be tapered from the first face to the second face to provide the radial misalignment.

Apparatus, and components for use in apparatus, for changing the concentration of a selected gas in a liquid, for example for degassing liquids. In one apparatus, the apparatus has a flow channel (a) through which the liquid is passed, and (b) which comprises a wall comprising a planar separation membrane, and (c) has a height of 0.00025-0.01 and an aspect ratio (width to height) of at least 25:1. One component, which can be used to support a separation membrane, comprises (a) an inner selection plate surface which comprises (i) a selection plate base and (ii) selection plate elements which (a) extend from the base, (b) are separated by intercommunicating selection areas, and (c) have outer surfaces remote from the selection plate base. Another component is a planar separation membrane which comprises (a) a membrane transmission section, and (b) a membrane peripheral member which surrounds the membrane transmission section and which includes location features which facilitate the location of the membrane at a desired position relative to another component.

Single-use integral chromatography unit having an inlet and an outlet, and comprising one or more plates or pairs of filter plates interposable between a pair of end plates. In certain embodiments, each of the filter plates comprises a polymeric framework with one or more membranes supported therein. The filter plates and end plates may be assembled to form a substantially fixed, substantially water-tight, integral stack. Fluid entering the unit through a common inlet passes the membrane or membranes of each filter plate substantially contemporaneously prior to exiting the unit through a common outlet (cf, “parallel” flow). The assembly is a modular design, as multiple pairs of plates can be stacked in a suitable holder to form a single chromatography unit.

A filtration module (1) has a filter unit (2) with at least one filter element (6) arranged between first and second plates (4, 5). The filter element (6) has at least one layer of filter material (9, 10) sealed off at a periphery by an edge seal (12). The plates (4, 5) are pressed against each other by a resilient bracketing profile (3) that engages around the plates (4, 5) at their opposite side surfaces (21, 22, 23, 24). The bracketing profile (3) has a base (13) that curves inward transversely to the longitudinal direction (14) of the plates (4, 5) and that is delimited by lateral brackets (16, 17) that are bent inward at their free ends (18, 19) to engage laterally around a surface (20) of the filter element (6) facing away from the base (13). A method also is provided for producing a filtration module.

The invention relates to membrane modules, in particular membrane pocket modules, which comprise membrane pocket stacks which are disposed in a housing having at least one feed inlet, at least one retentate outlet, and at least one permeate outlet. The invention also relates to the use of the membrane module according to the invention for separating mixtures of liquids and/or gases. The membrane of the previously known type, also referred to as a GS module, comprises a housing which for forming a container interior space by means of finisher discs at two end sides is closed in a pressure-tight manner. The finisher discs comprise at least one feed inlet, at least one retentate outlet, and one permeate outlet, wherein at least one membrane pocket stack which has a plurality of membrane pockets which are lined up beside one another and are mutually separated by seals and which are push-fitted onto a permeate tube is disposed in the container interior space. The permeate tube protrudes beyond the at least one permeate outlet of the finisher discs. The membrane module according to the invention is characterized in that the permeate tube and the permeate outlet of the finisher discs are aligned in an alternating manner by way of a key-and-groove connection.

Parallel plate devices for hemofiltration or hemodialysis are provided. A parallel plate device includes a parallel plate assembly having an aligned stack of stackable plate subunits, each stackable plate subunit having a through channel for blood, where the blood channels are opened up at opposite ends of the parallel plate assembly. The parallel plate assembly is configured to form filtrate/dialysate channels interleaved with the blood channels, adjacent channels being separated by a silicon nanoporous filtration membrane. A blood conduit adaptor is attached to the parallel plate assembly at each of the ends, and is configured to distribute blood to or collect blood from the blood channels. Also provided are systems and methods for using the parallel plate devices.

Disclosed herein are systems, devices, and methods for flowing fluid for radially expanded particle distribution within a laminar flow. In some variations, a system for cultivating tissue may comprise a bioreactor comprising an inlet, a substrate arranged in the bioreactor, and a diffusion module configured to transfer fluid from the inlet to the substrate. The diffusion module may comprise a porous material having at least one tortuous conduit extending between a first surface of the porous material and a second surface of the porous material.

A self-contained filtration assembly with a self-contained filtration cassette therein. The cassette may be formed from one or more layers membranes and spacers (spacers, screens, or combinations thereof) all having the same general shape. The cassette may have a feed inlet path and a retentate outlet path extending through the layers of the cassette within the perimeter of the cassette, and a permeate outlet path between the cassette exterior and the interior of the cassette housing. The housing may have a generally circular or elliptical cross-section. A clamping assembly may hold together the components of the housing, and may be elongated in a direction along the flow path of the feedstream through the cassette. Various port-defining zones defined in the layers of the cassette may be sealed in a manner facilitating assembly of the cassette as well as isolation of the flow paths therein.

The present invention relates to a crossflow membrane module configured to separate a feed fluid into a permeate fluid and a residue fluid across one or more membrane sheet(s). The crossflow module comprises a second end offset from a first end along the first direction where an inlet is provided at the first end and an outlet is provided at the second end. The one or more membrane sheet(s) each have a first portion and a second portion. A conduit is adjacent to the first side of each membrane sheet and is configured to receive and output the permeate fluid separated from the feed fluid. The second portion of the membrane sheet has a greater permeance for a major component than the first portion such that the second part of the permeate fluid, which is generated by separation across the second portion of the membrane sheet, has a higher concentration of the major component than the first part of the permeate fluid, which is generated by separation across the first portion. The second portion is spaced apart from the first side of the membrane sheet along the second direction thereby causing the second part of the permeate gas to flow towards the first side of the membrane sheet such that the second part of the permeate gas mixes with the first part of the permeate gas thereby reducing the concentration of the minor component in the first part of the permeate gas.

The invention relates to a modular flow system having a plurality of frame elements (101, 102) configured to be combined together to form a stack for forming afunctional member such as in particular a membrane distillation stage, a vapor generator, a condenser, a heat exchanger, a filter and/or a pervaporation stage, wherein the frame elements (101, 102) each include: an outer frame (39) and an inner frame (43), the inner frame (43) encasing a central inner region (40) and being surrounded by the outer frame (39), passage openings (13 to 16) and vapor and/or liquid channels (17, 18) arranged between the outer frame (39) and the inner frame (43), wherein at least one of the vapor and/or liquid channels (17, 18) comprises at least one internal strut member (48) extending between the inner frame (43) and the outer frame (39).