An oxygenator having a plurality of porous hollow fiber membranes for gas exchange to treat blood is manufactured by dissolving a silicone compound in an organic solvent having a surface tension of less than 70 dyn/cm to prepare a coating solution, and bringing an inner surface of the hollow fiber membranes into contact with the coating solution under a negative pressure of 50 hPa or more and 150 hPa or less to form a silicone compound-containing coating layer on the inner surface. An antithrombotic polymer compound-containing coat can be provided directly on an outer surface of the hollow fiber membranes.

The present disclosure relates to systems and methods for electrically conductive membrane separation from a mixture solution via membrane nanofiltration, electro-filtration, or electro-extraction by: generating an electric field at the membrane filter, holding the membrane filter at a constant electric potential, or driving a constant current through the membrane filter; feeding a mixture solution through the membrane nanofiltration system; and separating a component from the mixture solution into a permeate solution.

There is provided a multi-layered membrane comprising a top layer, a bottom layer, and a spacer layer; wherein said spacer layer is interposed between said top layer and said bottom layer; wherein said top layer, said bottom layer and said spacer layer are each independently composed of one or more selective layers, each selective layer comprising a 2D material; wherein said spacer layer comprises at least one channel for receiving a fluid; wherein said bottom layer comprises a hole with an area in the range of 1 μm.sup.2 to 1 mm.sup.2; and wherein said hole is capable of being in fluid communication with said at least one channels of said spacer layer.

There is also provided a method to synthesize the top layer of a multi-layered membrane as disclosed herein, methods for separating a plurality of ions or molecules in a fluid stream, a device comprising a multi-layered membrane as disclosed herein, and use of the method or the device as disclosed herein in osmotic power generation.

Parallel plate devices for hemofiltration or hemodialysis are provided. A parallel plate device includes a parallel plate assembly having an aligned stack of stackable plate subunits, each stackable plate subunit having a through channel for blood, where the blood channels are opened up at opposite ends of the parallel plate assembly. The parallel plate assembly is configured to form filtrate/dialysate channels interleaved with the blood channels, adjacent channels being separated by a silicon nanoporous filtration membrane. A blood conduit adaptor is attached to the parallel plate assembly at each of the ends, and is configured to distribute blood to or collect blood from the blood channels. Also provided are systems and methods for using the parallel plate devices.

A permeate device includes at least one non-porous, gas permeable element configured for contact with a liquid flow and at least one element fabricated from a porous material configured to permit gas flow therethrough. The permeate device may include a vacuum chamber that surrounds an operative portion of a permeation zone. A method for processing a liquid flow to remove entrained gas includes providing a liquid flow that includes an initial level of entrained gas, delivering the liquid flow to a permeate device, wherein the permeate device includes (i) at least one non-porous, gas permeable element configured for direct contact with the flow; and (ii) at least one element fabricated at least in part from a porous material configured so as to permit gas flow therethrough, and applying a negative pressure to the permeate device to draw entrained gas from the flow within an operative portion of the permeate device.

Parallel plate devices for hemofiltration or hemodialysis are provided. A parallel plate device includes a parallel plate assembly having an aligned stack of stackable plate subunits, each stackable plate subunit having a through channel for blood, where the blood channels are opened up at opposite ends of the parallel plate assembly. The parallel plate assembly is configured to form filtrate/dialysate channels interleaved with the blood channels, adjacent channels being separated by a silicon nanoporous filtration membrane. A blood conduit adaptor is attached to the parallel plate assembly at each of the ends, and is configured to distribute blood to or collect blood from the blood channels. Also provided are systems and methods for using the parallel plate devices.

The invention relates to the technical field of membrane separation, in particular to and discloses a preparation method of a high-performance MABR hollow fiber composite membrane, which comprises the following steps: 1) pretreating a supporting membrane, which includes: soaking the supporting membrane in ethanol, then soaking the supporting membrane in pure water, and then removing residual water; 2) preparing a coating solution, which includes: mixing raw silicone rubber and a reinforcing material with a continuous stirring, adding a crosslinking agent and a catalyst and stirring well, adding a solvent to dilute to a required concentration, and perform a vacuum defoaming; 3) coating the pretreated supporting membrane, which includes: coating and pulling; and 4) performing a curing, which includes: placing the membrane in an oven for curing. With the preparation method of the high-performance MABR hollow fiber composite membrane according to this invention, the prepared composite membrane has a higher oxygen permeability and a higher bubble point pressure of the dry membrane, which facilitates the transmission of oxygen across the membrane and enables the composite membrane to bear a higher aeration pressure during its operation, and ensures the operation efficiency of the MABR system, with advantages of a simple and feasible process, a suitability for the microporous support membrane of various materials and a good modification effect.

A diagnostic chip for detecting biomarkers and trace amounts of nanoparticles in chemical mixtures or in water. The diagnostic chip includes one or more inputs, where a sample containing differently sized particles is introduced into at least one of these inputs. Furthermore, the diagnostic chip includes multiple separation regions, where the sample is pressurized as it passes through the separation regions. Each separation region includes a deterministic lateral displacement array, where the deterministic lateral displacement array in two or more of these separation regions has a different etch depth profile. In this manner, the diagnostic chip effectively detects biomarkers and trace amounts of nanoparticles in chemical mixtures or in water.

The present disclosure provides an improved filtration membrane suitable for filtration of blood in vivo. The improved filtration membrane is resistant to breakage with minimal areal penalty due to presence of a system of supports on the backside of the membrane. The minimal areal penalty is achieved by using supports that provide a hierarchical scaffolding that comprises ribs of two different heights as disclosed herein.

The present technology provides micro fabricated filtration devices, methods of making such devices, and uses for microfabricated filtration devices. The devices may allow diffusion to occur between two fluids with improved transport resistance characteristics as compared to conventional filtration devices. The devices may include a compound structure that includes a porous membrane overlying a support structure. The support structure may define a cavity and a plurality of recesses formed in a way that can allow modified convective flow of a first fluid to provide improved diffusive transport between the first fluid and a second fluid through the membrane.