Provided herein are methods for making liposomal API formulations via continuous in-line diafiltration processes. Also provided herein are liposomal API formulations manufactured by the disclosed methods.

A device and method for in-line homogenizing a non-uniform feed stream is described herein, which includes a plug flow reactor (PFR), a bypass line, and a pump in a closed-circuit flow path that allows for rapid homogenization of the non-uniform feed stream.

Provided herein are methods for making liposomal API formulations via continuous in-line diafiltration processes. Also provided herein are liposomal API formulations manufactured by the disclosed methods.

An apparatus for producing a composition includes a holding device for holding first and second capsules including first and second deformable compartments, respectively, which contain a first formulation and a second formulation, respectively; a first compression element including a first compression surface designed to apply a pressure to the first deformable compartment of the first capsule; and a second compression element including a second compression surface designed to apply a pressure to the second deformable compartment of the second capsule. The first compression surface is designed to conduct and guide the contents of the first capsule to a first passage in the first capsule that can be fluidically connected to the first deformable compartment and the second compression surface is designed to conduct and guide the contents of the second capsule to a second passage in the second capsule that can be fluidically connected to the second deformable compartment.

A method of mixing a pharmaceutical solution including adding a gas into an interior compartment of a mix bag to form a headspace. The interior compartment of the mix bag includes a top portion and a bottom portion. The headspace adjacent to the top portion contains gas. The method includes adding a solvent into the mix bag, and establishing a bubble column in the interior compartment by activating a recirculation assembly. The recirculation assembly includes a connecting pathway operably coupled to a recirculation pump. A first end of the connecting pathway is coupled to a top gas recirculation port and a second end is coupled to a bottom gas recirculation port of the mix bag such that the recirculation pump draws the gas from the headspace and delivers the gas to the interior compartment via the bottom gas recirculation port. The method includes adding a solute into the mix bag.

A combinatorial drug delivery device is provided herein including: a plurality of serially connectable modules, each including at least one drug component; and, a master controller. Each of the modules includes: a power line; a ground line; a multiplexer having a plurality of identified input channels, at least a subset of the input channels being selectively connected to one of the power and ground lines; a first digital logic line configured to select the input channels; a voltage reference line having a first resistor in line with an output of the multiplexer; a branch line connected to the voltage reference line having a normally closed switch thereon to connect the branch line to the ground line, the switch being opened with connection to a further module. The master controller selects, in sequence, the same identified input channels across all of the modules with measuring a reference voltage thereacross.

A production apparatus includes a receiving device designed to receive a first and a second capsule containing a first and a second formulation, respectively, the receiving device being designed to be in an open position in which the first and the second capsule can be introduced into the receiving device and a closed position in which the receiving device holds the first and second capsules in position, the receiving device further being designed in such a way that when the receiving device holding the first and second capsules is moved from the open position to the closed position, the first and second capsules are connected; the apparatus further includes a mixing machine designed to receive the receiving device holding the first and second capsules, and to mix the first and second formulations contained in the first and second capsules such as to obtain the composition.

The present disclosure provides a method for generating a solution, comprising receiving a solution order. The solution order may comprise one or more order parameters for the solution. The solution order may be inputted into a trained algorithm that outputs one or more solution parameters for the solution. The one or more solution parameters may be used to generate the solution comprising a liquid from a plurality of liquids and a solid from a plurality of solids. The solution can meet the one or more order parameters at an accuracy of at least 90%. The solution may be dispensed.

Provided are a method for preparing liposomes comprising ultrasound reactive microbubbles for drug delivery, comprising (a) a step of producing ultrasound reactive microbubbles comprising an inert gas therein and having a first shell formed on the outer surface thereof, followed by forming a uniform size distribution of the ultrasound reactive microbubbles through an extruder; and (b) a step of producing liposomes comprising the ultrasound reactive microbubbles distributed in a uniform size and a medicament therein and having a second shell formed on the outer surface thereof, followed by forming a uniform size distribution of the liposomes through an extruder; and a liposome using same.

A gas mixer (100), to which a first gas and a second gas are fed, mixes the two fed gases to form a gas mixture. A helical component (2) is arranged in an interior of an outer component (5). A helical mixing cavity (20) is formed between the outer component and the helical component (2). An additional mixing volume (6) is located in the interior of the outer component (5) or in the interior of the helical component (2). One gas is sent through a first feed line (31) to the helical mixing cavity (20), and the other gas is sent through a second feed line (32) to the additional mixing cavity (6). A gas mixture discharge line (40) discharges the produced gas mixture from the helical mixing cavity (20).