An apparatus for mass producing monodisperse microbubbles includes a microfluidic flow focusing device, which includes a dispersed phase fluid supply channel having an outlet that discharges into a flow focusing junction, a continuous phase fluid supply channel having an outlet that discharges into the flow focusing junction, and a bubble formation channel having an inlet disposed at the flow focusing junction. The configuration of the flow focusing junction is such that, in operation, a flow of dispersed phase fluid discharging from the outlet of the dispersed phase fluid supply channel is engageable in co-flow by a focusing flow of continuous phase fluid discharging from the outlet of the at least one continuous phase fluid supply channel under formation of a gradually thinning jet of dispersed phase fluid that extends into the inlet of the bubble formation channel.

The present invention is related to a system and method for controlled manufacturing of mono-disperse microbubbles. According to the invention, the mono-disperse nature of the collection of generated microbubbles can be improved by releasing the pressurized gaseous medium used in the system using release valve units. This further allows the system to be embodied as a portable system. In turn, the operator of an ultrasound imaging apparatus may use the system according to the invention to generate microbubbles on a patient-by-patient basis.

A compounding apparatus for mixing at least two materials into an admixture can include a processor and software configured to select a non-universal ingredient for substitution as a temporary universal ingredient to be used as a buffer when an original universal ingredient buffer is not available. The processor and software can also include an auto adjust feature to correct for tube wear and other factors creating non-compliant final bag fills. The processor and software can also include a disable station designation feature that allows for disabling a problem station and diverting operation from the designated disabled station to a substitute station. Such operation can ensure continued production of the compounding apparatus.

A capped retail dispenser package encloses and retains a mixing container into which a product mixture is filled using an automated manufacturing system in an individualized manner, such that each individual product container may be charged with a customized or unique formulation different than a previous or subsequent container passing through the system. Mixing is not done prior to filling, but with a mixer received in a slidable bottom portion that functions as a piston. The rod terminates at its upper end with a mixing plate. Movement of the rod through the central opening provides mixing of the product through a reciprocating motion, and preferably with a simultaneous rotation. Movement of the upper mixing plate within the mixing container provides mixing of the container's contents by forcing fluid flow through one or more mixing apertures formed about a flange of the mixing plate.

A stabilized, gas-infused liquids containing ultra high concentrations of infused gas, produced by: generating a gas-infused liquid in a sealed vessel under a high pressure of at least 20 psi; stabilizing the gas-infused liquid by passing the liquid while still under the high pressure through a tubular flow path arrangement which compresses the infused gas into nano bubbles in the liquid; infusing an additional amount of the gas into the stabilized liquid by injecting the same, while still under high pressure, back into the sealed pressure vessel along with more of the gas; and again stabilizing the liquid by again passing liquid, while still under the high pressure, through the tubular flow path arrangement to thereby form the additional amount of infused gas into nano bubbles in the liquid.

The present invention relates to the field of micro fluidics. Specifically, the present invention relates to a novel flow cell for the selective enrichment of target particles or cells from a fluid. The flow cell exhibits a novel design which greatly improves the target particle or cell yield. The invention also provides a micro fluidic device, comprising the flow cell according to the invention. In another aspect, the invention relates to the use of a flow cell or a micro fluidic device of the invention for the isolation of target particles or cells from a fluid sample. Finally, the invention relates to a method for the selective enrichment of target particles or cells from a fluid using the flow cell of the invention.

This invention relates to a container (1) which is pre-filled or pre-fillable with one or more substances, such as a medical liquid and similar, comprising a squeezable activation compartment (2) intended to contain said one or more substances, a dispensing compartment (3) including a first portion (31) equipped with at least one dispensing member (311, 312, 314) of said one or more substances, and a second portion (32), wherein said second portion (32) of said dispensing compartment (3) and said activation compartment (2) are fluid-dynamically connected, and an activator element (4) arranged inside said container (1).

This invention also relates to a method for dispensing at least one substance by means of a container (1), and to a production method of a container (1).

An exemplary compounding system and method can include a transfer set that includes a manifold for assisting in transferring a plurality of ingredients from supply container(s) to a final container. The manifold can include a first channel in fluid communication with at least one primary ingredient, and a second channel in fluid communication with a plurality of secondary ingredients. The first channel and second channel can be in fluid isolation from each other such that the at least one primary ingredient does not mix with the plurality of secondary ingredients within the manifold. The transfer set can include a plurality of inlet lines in fluid communication with the manifold and two outlet lines configured for connection to two separate pumps and eventually being in fluid communication with the final container.

A medical gas-liquid supply system including an electrolytic gas generator, a pure water supply device, a control unit, a first gas storing unit, a second gas storing unit and a gas output unit is provided. The control unit is electrically connected to the electrolytic gas generator for controlling the voltage value of the electrolytic gas generator and the type of gases generated by the electrolytic gas generator. The first and second gas storing units are communicated to the electrolytic gas generator for storing the first and second gases generated by the electrolytic gas generator respectively. The gas output unit is communicated to the first and second gas storing units and has first, second and third output ends for outputting the first gas, a mixed gas and the second gas respectively, in which the mixed gas includes the first and second gases.

A storage and mixing device includes a mixing compartment, two pistons that each extend from the mixing compartment and end in a displacement section, each piston defining a passageway having a first opening communicating with the mixing compartment and a second opening communicating with an inlet at the displacement section, and a housing having two piston guides and a cartridge compartment connected to the piston guide, each piston guide slidably receiving one of the pistons, and each cartridge compartment receiving a removable cartridge that includes a cavity for containing separate substances and an opening sealed by a cartridge seal. The displacement section of each piston includes a piercing member for piercing the cartridge seal of the cartridge arranged in the corresponding cartridge compartment, such that the displacement section enters the cartridge cavity and displaces the contained substance into the mixing compartment via the inlet and the passageway.