The present invention relates to a continuous process for preparation of a stable agrochemical composition in microreactor processing system. The present invention also provides a stable agrochemical composition having mean particle size distribution and method of controlling undesired vegetation with said composition.

Provided herein are methods for making liposomal API formulations via continuous in-line diafiltration processes. Also provided herein are liposomal API formulations manufactured by the disclosed methods.

The invention relates to a microemulsion comprising water in an amount of 1-30 w %; sodium or potassium oleate, Na/K salts of tall oil fatty acid, and/or Na/K salts of C16-C18 saturated or unsaturated fatty acids in an amount of 10-40 w %; oleic acid, tall oil fatty acid, or C16-C18 saturated or unsaturated fatty acids in an amount of 2-40 w %; ethanol in an amount of 0-40 w %; glycerol in an amount of 5-40 w %; and liquid hydrocarbon(s) in an amount of 5-40 w %, up to a maximum or total of components parts of 100 w %. Moreover, methods of manufacture and uses of the microemulsion are disclosed.

Parallel uses of microfluidic methods and devices for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid are described. In some aspects, the present invention relates generally to flow-focusing-type technology, and also to microfluidics, and more particularly parallel use of microfluidic systems arranged to control a dispersed phase within a dispersant, and the size, and size distribution, of a dispersed phase in a multi-phase fluid system, and systems for delivery of fluid components to multiple such devices.

Devices, systems, and their methods of use, for generating droplets are provided. One or more geometric parameters of a microfluidic channel can be selected to generate droplets of a desired and predictable droplet size.

Provided herein are methods for making liposomal API formulations via continuous in-line diafiltration processes. Also provided herein are liposomal API formulations manufactured by the disclosed methods.

A method for preparing fluorescent-encoded microspheres coated with metal nanoshells is disclosed herein. By using SPG method, metal nano-material modified with a certain ligand is used as a new surfactant in the emulsification process, and different kinds and different amounts of fluorescent materials are doped into polymer microspheres to prepare fluorescent-encoded microspheres with different fluorescent-encoded signals and uniformly coated metal nanoshells in one step. The prepared fluorescent-encoded microsphere comprises a metal nanoshell, a polymer, and a fluorescent-encoded material. The fluorescent-encoded microsphere has a particle size of 1 μm˜20 μm, CV of less than 10%, which can be used for protein/nucleic acid detection. The preparation method has the advantages of simple process, high surface coating rate, good uniformity and controllable LSPR peaks, which can solve the problems of existing commonly used metal nanoshell coating methods such as low surface coating rate, poor uniformity, complex preparation process and uncontrollable local surface plasmon resonance (LSPR) peaks, etc.

Disclosed herein is a device (1) for generating a dispersion of a first phase in a second phase, the device comprising a first inlet (2) for supplying a first phase, which opens into a first chamber (4), a second inlet for supplying a second phase, opening into a second chamber and a dispersion outlet (6) for collecting the dispersion. Furthermore, the device comprises a membrane (7), which separates the first chamber (4) and the second chamber (5) and which comprises a first side (8) facing the first chamber (4) and a second side (9) facing the second chamber (5). The membrane (7) comprises multiple channels (10) extending from the first side (8) to the second side (9), providing a fluidic connection between the first chamber (4) and the second chamber (5). Each channel (10) comprises a channel inlet (11) arranged on the first side (8) mid a channel outlet 812) arranged on the second side (9). The first chamber (4) is typically configured such that a flow rate of the first phase through all of the individual channels (10) is essentially equal.

A method for validating a homogenizing valve (1), comprising the steps of: —preparing an emulsion having a hydrophilic phase comprising, in weight percentage on the total weight: from 55% to 74% demineralized water, from 10% to 20% glycerin and from 3% to 4,2% butylene glycol, and a lipophilic phase comprising, in weight percentage on the total weight: from 5.1% to 5.9% squalane, from 7.2% to 8.8% caprylic acid alkyl ester and from 0.665% to 0.735% cetyl alcohol; —subjecting the emulsion to forced passage within the homogenizing valve (1) from a high pressure zone (HP) to a low pressure zone (LP) a plurality of times.

A process for producing a microemulsion or nanoemulsion comprising water and at least one hydrocarbon or oil, comprising the steps of: a) providing the hydrocarbon or oil, water, one or more additives, a solvent, and a hydrophilic surfactant formulation comprising an amine or amide derivative non-ionic surfactant which is a fatty acid alkanolamide, one or more ethoxylated alcohols and/or ethoxylated alkylphenols, and a non-ionic fatty acid ester; b) by a mixing or stirring device operating at a mixing or stirring speed in the range 100 rpm and 15000 rpm, mixing or stirring the hydrophilic surfactant formulation and additive into the solvent, to produce a hydrophilic self-emulsifying blend; c) adding water to the hydrophilic self-emulsifying blend and the hydrocarbon or oil to produce a water-in-hydrocarbon/oil microemulsion or nanoemulsion, wherein the microemulsion or nanoemulsion comprises: 46% or more by mass of the hydrocarbon or oil, 4% to 36% by mass of water, a mass ratio of hydrophilic surfactant formulation to water in the range 1:10 to 1:2, 0.1% to 5% by mass of additive, 1.2% or more by mass of the solvent, a dispersed particle size in the range 1 nm to 500 nm, and a polydispersity index of 35% PdI or less, wherein the percentages by mass of the hydrocarbon or oil, water, formulation, additive and solvent together add up to 100%.