Provided herein are methods for making liposomal API formulations via continuous in-line diafiltration processes. Also provided herein are liposomal API formulations manufactured by the disclosed methods.

Provided herein are methods for making liposomal API formulations via continuous in-line diafiltration processes. Also provided herein are liposomal API formulations manufactured by the disclosed methods.

A system and method are presented for producing solder paste having undercooled metallic core-shell particles. In one or more arrangements, the system includes a reconstitution assembly, a dispenser assembly, and a mixer, among other components. The reconstitution assembly is configured to place the cores of the solid core metallic core-shell particles into an undercooled liquid state to form a plurality of undercooled metallic core-shell particles. The dispenser assembly is configured to dispense one or more of a set of available flux components. The mixer assembly is configured to mix the one or more of the set of flux components dispensed by the dispenser assembly with the plurality of undercooled metallic core-shell particles formed by the reconstitution assembly to form a solder paste.

Mobile systems for mixing and dispensing. The systems include a vehicle, a dispenser, a means for transferring a primary fluid to the dispenser from a primary fluid source, and one or more vessels of a secondary fluid that are fluidly connected to the dispenser. The dispenser includes an assembly of fluid distribution components that define a fluid channel that enables the primary fluid to flow through the dispenser. Incorporated into the fluid channel is an aspirator component that enables the dispenser to aspirate a secondary fluid into the fluid channel when the primary fluid is flowing through it, thereby yielding an operative fluid. Disclosed are embodiments of the system where the means for transferring a primary fluid is either a stand-alone pump or a truck mount. Also disclosed are embodiments of the system where the primary fluid source is a portable vessel located within the interior of the vehicle.

A method for preparing fluorescent-encoded microspheres coated with metal nanoshells is disclosed herein. By using SPG method, metal nano-material modified with a certain ligand is used as a new surfactant in the emulsification process, and different kinds and different amounts of fluorescent materials are doped into polymer microspheres to prepare fluorescent-encoded microspheres with different fluorescent-encoded signals and uniformly coated metal nanoshells in one step. The prepared fluorescent-encoded microsphere comprises a metal nanoshell, a polymer, and a fluorescent-encoded material. The fluorescent-encoded microsphere has a particle size of 1 μm˜20 μm, CV of less than 10%, which can be used for protein/nucleic acid detection. The preparation method has the advantages of simple process, high surface coating rate, good uniformity and controllable LSPR peaks, which can solve the problems of existing commonly used metal nanoshell coating methods such as low surface coating rate, poor uniformity, complex preparation process and uncontrollable local surface plasmon resonance (LSPR) peaks, etc.

An admixing system for fire-extinguishing installations is provided for generating a mixture (premix) of extinguishing medium and extinguishing medium additive by admixing an extinguishing medium additive to an extinguishing medium. The admixing system has a motor that can be driven by a flow of extinguishing medium, an admixing pump that is connected to the motor and serves for supplying the extinguishing medium additive to an extinguishing medium additive inlet line, an admixing line, and an extinguishing medium additive outlet line from which the extinguishing medium additive is admixed to the extinguishing medium in the admixing line. The admixing pump is a piston pump having multiple cylinders and at least two outputs connected to the cylinders. At least one first output, through which return flow is possible, can be switchably fluidically connected either to a return flow line through which the extinguishing medium additive flows back to the admixing pump, or to the extinguishing medium additive outlet line. If the extinguishing medium additive flows from the return-flow-compatible output back to the admixing pump, it is therefore not admixed to the extinguishing medium in the admixing line. Thus, the admixing rate can be changed simply by means of this switching.

A combinatorial drug delivery device is provided herein including: a plurality of serially connectable modules, each including at least one drug component; and, a master controller. Each of the modules includes: a power line; a ground line; a multiplexer having a plurality of identified input channels, at least a subset of the input channels being selectively connected to one of the power and ground lines; a first digital logic line configured to select the input channels; a voltage reference line having a first resistor in line with an output of the multiplexer; a branch line connected to the voltage reference line having a normally closed switch thereon to connect the branch line to the ground line, the switch being opened with connection to a further module. The master controller selects, in sequence, the same identified input channels across all of the modules with measuring a reference voltage thereacross.

A first solution is mixed and diluted with diluting liquid to make a first dilute solution, a second solution is mixed and diluted with diluting liquid to make a second dilute solution, and the first dilute solution and second dilute solution, both diluted with diluting liquid, are mixed in a sealed tank.

A system includes a dip tube, a feed line, and a check valve. The dip tube is inserted through an opening in a source of chemical precursor and into the chemical precursor in the source. A portion of the feed line is located in the dip tube. The feed line passes out of the dip tube. The chemical precursor is capable of flowing out of the source through the feed line in a downstream direction. The check valve is located in the portion of the feed line in the dip tube. The check valve permits the chemical precursor to pass substantially only in the downstream direction. The feed line is coupled to a transfer pump that draws the chemical precursor out of the source through the portion of the feed line in the dip tube.

A mixing device and method for generating reaction plastic, the mixing device including: a mixing chamber configured to mix reactive components to generate the reaction plastic; a discharge unit, including a discharge pipe connected to the mixing chamber configured to discharge the reaction plastic generated in the mixing chamber; a cleaning piston that is axially aligned with the discharge pipe of the discharge unit and is moveable into the discharge pipe to clean reaction plastic from the discharge pipe; a fluid supply device configured to provide a lubricant into the discharge unit via an outlet to lubricate the discharge unit, a control piston arranged within the mixing chamber and configured to control flow of the reactive components; wherein an axial direction of the control piston is oblique to an axial direction of a discharge pipe of the discharge unit.