A process and a device for continuous micromixing of two fluids is disclosed. The process and the device can be used in particular when micromixing plays an important role, for example, in the yield and characteristics of the products. This is the case for crystallization, precipitation and combustion reactions and for micelle assembly or polyelectrolyte complexation processes.

This invention describes a design for a multiwell plate that contains integrated pumps that are used to stir each well of the plate. The device employs microfluidic logic technology to drive each peristaltic pump. This enables the plates to run autonomously, requiring only a static vacuum supply for power. The devices are entirely constructed out of low-cost polymers, with no electronics, and yet contains simple digital logic circuits to control the pumps. A stack of these plates may be run continuously in a standard cell culture incubator, allowing high-throughput culture of organoids.

An automated apparatus for preparing a liquid bioprocess solution includes at least one mixing chamber having a lower port and an upper port for fluid to enter the at least one mixing chamber, an array of tubing for fluid flow within the system, a plurality of valves provided within the tubing, and a mixing controller configured to cause the automated apparatus to perform a series of sequential mixing steps causing the preparation of the liquid bioprocess solution from a dry ingredient. The series of sequential mixing steps include opening a first valve associated with the lower port to provide fluid to the at least one mixing chamber through the lower port, and after a predetermined amount of elapsed time, closing the first valve and opening a second valve associated with the upper port to provide fluid to the at least one mixing chamber through the upper port.

A fluid mixer for a reactor of a hydrocarbon processing plant includes a substantially cylindrical mixing chamber, at least one first inlet for conducting first fluid to the mixing chamber from above the mixing chamber and along a side wall of the mixing chamber to produce a spiral stream in the mixing chamber, at least one second inlet for conducting second fluid tangentially into the spiral stream, and an outlet channel for conducting the first and second fluids downwards out from the mixing chamber. The outlet channel is concentric to the mixing chamber and includes a mixing structure for enhancing mixing of the first and second fluids. At least a part of the mixing structure is located below an upper edge of the outlet channel and produces turbulence in a stream of the first and second fluids flowing in the outlet channel.

Provided are a bubble generation apparatus and a washing device, the bubble generation apparatus includes a gas dissolution chamber, a bypass member, and a bubbler. The gas dissolution chamber has a vent opening, a liquid inlet, and a liquid outlet, the bypass member has a gradually contracting section, a throat part, and a gradually expanding section which are connected in sequence from a bypass inlet to a bypass outlet; the bubbler is connected to the liquid outlet, the bypass inlet or bypass outlet of the bypass member is connected to the liquid inlet to supply liquid into the gas dissolution chamber, and the throat part is connected to the vent opening or a gas storage space in the gas dissolution chamber.

Provided is a technique for efficiently mixing a plurality of liquids by using only a single liquid feeding device. This liquid mixer comprises: a first inflow flow path into which a first liquid flows; a second inflow flow path into which a second liquid flows; a liquid merging part where the first liquid and the second liquid merge; an outflow flow path which is connected to the liquid merging part and through which the first liquid and the second liquid flow out; and a single liquid feeding device. The liquid merging part has a first flow path connected to the first inflow flow path, and a second flow path connected to the second inflow flow path, the first flow path branches into at least two flow paths, and the second flow path branches into at least two flow paths. One among the flow paths branched from the first flow path and one among the flow paths branched from the second flow path are connected and merged with each other. Another one of the flow paths branched from the first flow path and another one among the flow paths branched from the second flow path are connected and merged with each other on the downstream side, and are connected to the outflow flow path.

An automated method includes providing a dry ingredient to be reconstituted into a liquid bioprocess solution and controlling, by a processing circuit, all automated system including at least one mixing chamber, an array of tubing for fluid flow within the system, and a plurality of valves provided within the tubing, to automatically prepare the liquid bioprocess solution from the dry ingredient. Controlling the auto system may include performing a series of sequential mixing steps, the series of sequential mixing steps causing the preparation of the liquid bioprocess solution. The method mixing include taking one or more measurements during the preparation of the liquid bioprocess solution, wherein each step is triggered by at least one of a measurement decreasing below, equaling, or exceeding a measurement threshold. Each step may also include opening or closing, by the processing circuit, at least one of the plurality of valves.

A mixer for mixing a fluid solution, such as a diesel exhaust fluid for selective catalytic reduction, with a gas, such as an exhaust gas, includes a mixing chamber with a general cylinder shape obtained by translation of a polarly period section along a first axis. The fluid solution is sprayed in the mixing chamber by way of a first axial end thereof. The gas enters the mixing chamber through openings formed in a generatrix surface of said mixing chamber, and the mixture exits through a second axial end opposite the first axial end. The polarly period section is shaped in a star, obtained by polarly periodically repeating an elementary profile, comprising an opening defined by a first angle between a first segment passing through the two ends of said opening and a radial line passing through the distal end of said first segment.

An artificial-whirlpool generator includes a whirlpool generating member including at least one water inlet, a whirlpool generating chamber communicating with the water inlet, and a whirlpool outlet that is formed at a lower end portion of the whirlpool generating member and communicates with the whirlpool generating chamber; a position-fixing means that fixes the whirlpool forming member such that the entirety of the whirlpool generating member or only a portion of the whirlpool generating member, including the whirlpool outlet is submerged; and a swirling flow forming unit that forces water in a waterbody to be introduced into the whirlpool generating chamber through the water inlet and rotates the introduced water in one direction around an axle provided at a center portion of the whirlpool generating chamber to form a whirlpool that descends toward the whirlpool outlet.

The invention concerns a method and system for determining dissolution properties of a particle. The method comprises providing into a vessel dissolution medium capable of dissolving the particle and providing the particle into said vessel in contact with the dissolution medium for dissolving the particle. According to the invention, the particle is trapped in a particle trapping zone formed at a predetermined location in the vessel, the particle trapping zone being formed preferably at least partially by continuous hydrodynamic motion of the dissolution medium. Residue of the particle is imaged while being trapped in said particle trapping zone for providing a plurality of sequential images of the particle residue. Finally, at least one dissolution property of the particle is determined based on the sequential images. The invention allows for dissolution rate, intrinsic dissolution rate and/or solubility of matter to be reliably determined from very small sample amounts and without manual affixation of samples.