A rotation mixer including a housing, a drive unit coupled to the housing, a carriage mounted on the drive unit for rotation relative to the housing, and a basket mounted for rotation relative to the carriage. The basket receives material to be mixed. The carriage includes an arm and a drive line coupled to the arm. The arm is mounted on the drive unit for rotation about a first axis relative to the housing, and the drive line converts rotation of the arm into rotation of the basket about a second axis relative to the arm during use of the rotation mixer. The drive line illustratively includes a belt and plurality of pulleys upon which the belt travels in a continuous loop, the belt engaging with a gear on the basket to cause rotation of the basket.

A rotation mixer including a housing, a drive unit coupled to the housing, a carriage mounted on the drive unit for rotation relative to the housing, and a basket mounted for rotation relative to the carriage. The basket receives material to be mixed. The carriage includes an arm and a drive line coupled to the arm. The arm is mounted on the drive unit for rotation about a first axis relative to the housing, and the drive line converts rotation of the arm into rotation of the basket about a second axis relative to the arm during use of the rotation mixer. The drive line illustratively includes a belt and plurality of pulleys upon which the belt travels in a continuous loop, the belt engaging with a gear on the basket to cause rotation of the basket.

A self-balancing adapter for use with a mixer, the adapter having a body configured to interface with the mixer as a unit, the body having a front and a back, left and right edges, a top and a bottom, and a vertical axis passing through the top and the bottom, where the front has at least a first recess configured to receive and hold a first vessel substantially within the body; and the adapter having at least one movable counterweight configured to be displaced when the first vessel is received in the first recess such that the movable weight at least partially offsets a weight of the first vessel within the body with respect to the vertical axis.

A process for making an oligonucleotide, the process including reacting a oligonucleotide precursor with a solid phase support within a reaction vessel, the reaction vessel being coupled to an actuator and having a resting position and inverting the reaction vessel via the actuator such that the reaction vessel is inverted relative to the resting position, wherein the inversion of the reaction vessel results in stirring of the solid phase support within the reaction vessel.

A process for making an oligonucleotide, the process including reacting a oligonucleotide precursor with a solid phase support within a reaction vessel, the reaction vessel being coupled to an actuator and having a resting position and inverting the reaction vessel via the actuator such that the reaction vessel is inverted relative to the resting position, wherein the inversion of the reaction vessel results in stirring of the solid phase support within the reaction vessel.

A rotation mixer including a housing, a drive unit coupled to the housing, a carriage mounted on the drive unit for rotation relative to the housing, and a basket mounted for rotation relative to the carriage. The basket receives material to be mixed. The carriage includes an arm and a drive line coupled to the arm. The arm is mounted on the drive unit for rotation about a first axis relative to the housing, and the drive line converts rotation of the arm into rotation of the basket about a second axis relative to the arm during use of the rotation mixer. The drive line illustratively includes a belt and plurality of pulleys upon which the belt travels in a continuous loop, the belt engaging with a gear on the basket to cause rotation of the basket.

A rotation mixer including a housing, a drive unit coupled to the housing, a carriage mounted on the drive unit for rotation relative to the housing, and a basket mounted for rotation relative to the carriage. The basket receives material to be mixed. The carriage includes an arm and a drive line coupled to the arm. The arm is mounted on the drive unit for rotation about a first axis relative to the housing, and the drive line converts rotation of the arm into rotation of the basket about a second axis relative to the arm during use of the rotation mixer. The drive line illustratively includes a belt and plurality of pulleys upon which the belt travels in a continuous loop, the belt engaging with a gear on the basket to cause rotation of the basket.

A detection method uses a reaction vessel including a container including a housing part having a first opening opened at an upper portion and a second opening opened at a side portion, and a side wall member fixed to the container so that a capturing region on a metal film is exposed in the second opening. First, a liquid containing a specimen is provided to the housing part. Next, the liquid in the housing part is stirred to capture, into the capturing region, a substance to be detected in the liquid. Next, the metal film is irradiated with light so that surface plasmon resonance occurs in the metal film, and light emitted from the reaction vessel and having a light amount changing depending on the amount of the substance to be detected captured in the capturing region is detected. In the step of providing the liquid to the housing part, an amount of liquid in which the liquid is not in contact with the capturing region when the liquid in the housing part is left still, and the liquid is in contact with the capturing region when the liquid in the housing part is stirred is provided to the housing part.

A process for making an oligonucleotide, the process including reacting a oligonucleotide precursor with a solid phase support within a reaction vessel, the reaction vessel being coupled to an actuator and having a resting position and inverting the reaction vessel via the actuator such that the reaction vessel is inverted relative to the resting position, wherein the inversion of the reaction vessel results in stirring of the solid phase support within the reaction vessel.

A process for making an oligonucleotide, the process including reacting a oligonucleotide precursor with a solid phase support within a reaction vessel, the reaction vessel being coupled to an actuator and having a resting position and inverting the reaction vessel via the actuator such that the reaction vessel is inverted relative to the resting position, wherein the inversion of the reaction vessel results in stirring of the solid phase support within the reaction vessel.