The current invention concerns a method for preparing an emulsion comprising the steps: mixing a first phase and a second phase in a layer multiplier to produce a multilayered fluid structure, and collapsing said multilayered fluid structure, thereby dispersing the second phase in the first phase creating an emulsion. The current invention relates to a method for producing dispersions. The current invention also concerns the emulsions produced by said method. The current method also relates to polymer emulsions, particularly polyisobutene emulsions with a high content of polyisobutene.

Apparatus for producing fine particles having a particle formation mechanism and a particle-outlet micro-channel may include a unit-structure including first and second portions adjacent to each other; and a first inlet defined in the first portion at a first height. A continuous phase solution is injected into the first inlet; and a second inlet is defined in the first portion at a second height different from the second height. A dispersed phase solution is injected into the second inlet. A merging volume is defined in the second portion and is defined at third height equal to either the first height and the second height, or has a value therebetween. The continuous phase solution and the dispersed phase solution are merged in the merging volume, wherein fine particles are formed. A first micro-channel and a second micro-channel branching from the merging volume communicates with the first inlet and the second inlet, respectively.

The invention provides a microdroplet- or bubble-producing device that does not require separate through-holes for different liquid droplet/air bubble-producing flow channels. The droplet-producing flow channels are configured in a three-dimensional manner unlike in a conventional device where they are configured in a two-dimensional plane, and therefore the flow channels can be provided in a more high-density configuration than the prior art. In the microdroplet/bubble-producing device comprising slit(s) and the row of the plurality of microflow channels, the slit(s) is/are a continuous phase supply slit, a dispersion phase supply slit and a discharge slit, the plurality of microflow channels are configured so that the ends of the slit(s) and the two supply ports on both sides or the supply port and discharge port on either side are mutually connected, and at the sites of connection between the microflow channels and the slit(s), the dispersion phase undergoes shear with the continuous phase flow as the driving force, producing droplets or air bubbles of the dispersion phase, which are recovered from the discharge port.

A micro-reactor system for contacting fluids is described. The system comprises a first microfluidic channel structure for guiding a first fluid to at least one output nozzle thus generating a first sub-flow, a second microfluidic channel structure for guiding a second fluid to at least a second output nozzle thus generating a second sub-flow, said first output nozzle being aligned with said second output nozzle and arranged for contacting the first sub-flow and the second sub-flow. The micro-reactor comprises at least a third microfluidic channel structure for at least a third, inert, fluid generating at least a third sub-flow arranged to be positioned adjacent at least the first and/or the second sub-flows so as to act as a wall between said first and/or second sub-flows.

A distributor is described for distributing a fluid flow from a smaller to a more broad fluid flow. It comprises a fluid input and a plurality of fluid outputs, and a channel structure in between the fluid input and the plurality of fluid outputs. The channel structure comprises alternatingly bifurcating channel substructures and common channel substructures wherein the substructures are arranged so that fluid exiting different channels from a bifurcating channel substructure mixes in a subsequent common channel substructure, and whereby fluid channels of the bifurcating channel substructure are arranged such that these do not contact the subsequent common channel substructure at the edges thereof.

The present invention provides a micro two-phase droplet generating device that does not require separate through-holes corresponding to a plurality of two-phase dispersed parallel continuous flow channels. The micro two-phase droplet generating device of the present application comprises a row of a plurality of microflow channels, liquid transfer ports, and a slit, and is configured so as to form two-dispersion phase parallel continuous flows at first connection sites between the plurality of microflow channels, in which a first dispersion phase flows, and the slit, through which a second dispersion phase flows. A continuous phase is fed to second connection sites between the plurality of microflow channels, in which the two-dispersion phase parallel continuous flows flow, and another liquid transfer port, which is preferably a second slit, downstream of the slit, and the two-dispersion phase parallel continuous flows are sheared at the second connection sites, whereby two-phase droplets, and in particular, core-shell or Janus two-phase droplets, can be generated, and a product can be collected from a discharge port.

The present invention provides a micro two-phase droplet generating device that does not require separate through-holes corresponding to a plurality of two-phase dispersed parallel continuous flow channels. The micro two-phase droplet generating device of the present application comprises a row of a plurality of microflow channels, liquid transfer ports, and a slit, and is configured so as to form two-dispersion phase parallel continuous flows at first connection sites between the plurality of microflow channels, in which a first dispersion phase flows, and the slit, through which a second dispersion phase flows. A continuous phase is fed to second connection sites between the plurality of microflow channels, in which the two-dispersion phase parallel continuous flows flow, and another liquid transfer port, which is preferably a second slit, downstream of the slit, and the two-dispersion phase parallel continuous flows are sheared at the second connection sites, whereby two-phase droplets, and in particular, core-shell or Janus two-phase droplets, can be generated, and a product can be collected from a discharge port.

Provided are scalable, parallelized microfluidic chips that include arrays of microfluidic mixing channels for large-scale production of lipid nanoparticles, among other products. The disclosed chips can operate with a single set of inlets and outlet, and achieve production rates in excess of those achieved by existing methods. The disclosed devices provide large-scale production of formulations while still maintaining the physical properties and potency typical of existing methods of producing such formulations. Also provided are related methods of using the disclosed devices.

Provided are scalable, parallelized microfluidic chips that include arrays of microfluidic mixing channels for large-scale production of lipid nanoparticles, among other products. The disclosed chips can operate with a single set of inlets and outlet, and achieve production rates in excess of those achieved by existing methods. The disclosed devices provide large-scale production of formulations while still maintaining the physical properties and potency typical of existing methods of producing such formulations. Also provided are related methods of using the disclosed devices.

According to one embodiment, a fluid controller includes a fluid channel deforming portion and a mixing portion provided downstream from the fluid channel deforming portion. The fluid channel deforming portion includes an upstream end portion, a first channel, a second channel and a channel terminating portion. At least one of the first and second channels is deformed between the upstream end portion and the channel terminating portion. A region of the second channel in a second cross-section, is increased more than a region of the second channel in the first cross-section, between the upstream end portion ad the channel terminating portion. The mixing portion mixes a plurality of fluids flowing through the fluid channel deforming portion.