The manufacturing apparatus includes a first capsule containing a first formulation; a second capsule containing a second formulation; a receiving device configured to receive the first and second capsules; a mixing machine including a receiving housing configured to receive the receiving device equipped with the first and second capsules, and a control unit configured to control the operation of the mixing machine; and a detection device configured to detect the presence of the receiving device in the receiving housing.

The manufacturing apparatus includes a first capsule containing a first formulation; a second capsule containing a second formulation; a receiving device configured to receive the first and second capsules; a mixing machine including a receiving housing configured to receive the receiving device equipped with the first and second capsules, and a control unit configured to control the operation of the mixing machine; and a detection device configured to detect the presence of the receiving device in the receiving housing.

The invention provides devices for generating pre-templated instant partitions. The devices may include a shearing mechanism, such as a vortexer, a holder for holding a vessel containing a liquid onto the vortexer, and a temperature control unit for modulating a temperature of the vessel by convection. The invention also provides methods of using such devices to process analyte inside the pre-templated instant partitions.

The invention provides devices for generating pre-templated instant partitions. The devices may include a shearing mechanism, such as a vortexer, a holder for holding a vessel containing a liquid onto the vortexer, and a temperature control unit for modulating a temperature of the vessel by convection. The invention also provides methods of using such devices to process analyte inside the pre-templated instant partitions.

A system includes a dip tube, a feed line, and a check valve. The dip tube is inserted through an opening in a source of chemical precursor and into the chemical precursor in the source. A portion of the feed line is located in the dip tube. The feed line passes out of the dip tube. The chemical precursor is capable of flowing out of the source through the feed line in a downstream direction. The check valve is located in the portion of the feed line in the dip tube. The check valve permits the chemical precursor to pass substantially only in the downstream direction. The feed line is coupled to a transfer pump that draws the chemical precursor out of the source through the portion of the feed line in the dip tube.

A direct drive batch mixing system including a vessel having an interior region for receiving a batch, a direct drive electric motor attached to at least one rigid point, a multi-axis load cell located between the motor and the rigid point to provide signals representing forces and moments in multiple axes, and an impeller located within the interior region of the vessel and engaged with the motor such that the motor rotates the impeller. Forces and loads on the impeller are directly supported by the motor and measured by the multi-axis load cell. In some embodiments, a programmable controller generates control signals that control the motor's speed (RPM), torque and direction of rotation, and receives feedback signals for adjusting the motor's speed and/or torque and/or direction of rotation.

A direct drive batch mixing system including a vessel having an interior region for receiving a batch, a direct drive electric motor attached to at least one rigid point, a multi-axis load cell located between the motor and the rigid point to provide signals representing forces and moments in multiple axes, and an impeller located within the interior region of the vessel and engaged with the motor such that the motor rotates the impeller. Forces and loads on the impeller are directly supported by the motor and measured by the multi-axis load cell. In some embodiments, a programmable controller generates control signals that control the motor's speed (RPM), torque and direction of rotation, and receives feedback signals for adjusting the motor's speed and/or torque and/or direction of rotation.

A microfluidic apparatus includes a substrate defining a microchannel having inlet and an outlet defining a length of the microchannel. The microchannel has a main channel extending from the inlet to the outlet, and a plurality of side cavities extending from the main channel. The cavities are in fluid communication with the main channel. A method includes introducing a sample into the microchannel through the inlet to fill the entire microchannel, and then introducing a solvent into the microchannel through the inlet at a controlled flow rate and inlet pressure. A developed solvent front then moves along the main channel from the inlet to the outlet while displacing the sample in the main channel. Images of the microchannel are acquired as the front moves, and a miscibility condition is determined based on the images.

A microfluidic apparatus includes a substrate defining a microchannel having inlet and an outlet defining a length of the microchannel. The microchannel has a main channel extending from the inlet to the outlet, and a plurality of side cavities extending from the main channel. The cavities are in fluid communication with the main channel. A method includes introducing a sample into the microchannel through the inlet to fill the entire microchannel, and then introducing a solvent into the microchannel through the inlet at a controlled flow rate and inlet pressure. A developed solvent front then moves along the main channel from the inlet to the outlet while displacing the sample in the main channel. Images of the microchannel are acquired as the front moves, and a miscibility condition is determined based on the images.

The present disclosure provides for a first embodiment, where, a first, lower shaft speed mixing of the component combination takes place in a thermokinetic mixer, where monitoring of the batch by temperature rate increase determination results in a determination that a substantial portion of desired thermokinetic mixing has occurred, whereafter a different shaft speed is used to complete the desired thermokinetic mixing of the component combination.