A process for continuous preparation of halogenated alkoxyethane of general formula XClHC—CF.sub.2OR, where X is —Cl or -f and OR is C.sub.1-4 alkoxy, the process comprising a step of introducing in a flow reactor reaction components comprising (i) a compound of general formula XClHC—CYF.sub.2, where each of X and Y is independently —Cl or —F, (ii) a base, and (iii) a C.sub.1-4 alkanol, wherein a) the flow reactor comprises one or more tubular flow line(s) through which the reaction components flow as a reaction mixture, c) the halogenated alkoxyethane is formed at least upon the reaction components mixing, with the so formed halogenated alkoxyethane flowing out of the flow reactor in a reactor effluent, and b) the base is one that forms a salt soluble in the alkanol during formation of the halogenated alkoxyethane.

Parallel uses of microfluidic methods and devices for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid are described. In some aspects, the present invention relates generally to flow-focusing-type technology, and also to microfluidics, and more particularly parallel use of microfluidic systems arranged to control a dispersed phase within a dispersant, and the size, and size distribution, of a dispersed phase in a multi-phase fluid system, and systems for delivery of fluid components to multiple such devices.

The present disclosure provides processes and apparatuses for the scaled-up manufacture of lomustine via continuous flow manufacture. Such continuous flow processes may optionally include the crystallization of lomustine and the apparatuses may optionally include crystallization apparatuses/reactors in either batch or continuous flow design. In one aspect of the disclosure, a process for making lomustine is provided comprising treating solutions of 2-chloroethylisocyanate with a solution of cyclohexylamine with continuous-flow pumps in a gram-flow reactor to form a combined solution, adding deionized water with a continuous flow-pump to the combined solution to form a liquid-organic phase solution, extracting the organic phase from the solution and treating with a solution of t-butyl nitrite with a continuous flow pump in a gram flow reactor to form lomustine.

A method for analyzing a catalyst in a catalytic reactor that operates under non-isothermal conditions includes the steps of: positioning a catalyst basket within a catalyst bed within the catalytic reactor, the catalyst basket containing catalyst material the forms the catalyst bed; operating the catalytic reactor, the catalyst basket having dimensions such that a temperature difference (ΔT) along an axial direction (height) of the catalyst basket is non-isothermal; and analyzing the catalyst material contained within the catalyst basket. The temperature difference (ΔT) is, in one embodiment, within a range of 1° C. to 40° C. and preferably, within a range of 5° C. to 25° C.

A chemical manufacturing system is used in chemical reactions involving a gas, gases or liquid which is turned into a gas, reacting with a solid or liquid, inside a closed reactor system. The chemical manufacturing system is designed to produce highly reactive materials on an industrial scale in a controllable fashion. The modular design and shape of the reactor system and the controls of the system account for the differentiation and improvements over conventional reactor systems.

The present disclosure provides fluidic devices and fluidic device assemblies, including microfluidic devices and cartridges comprising the same, that in illustrative embodiments, can be used to make particles or protein precipitates, or to monitor precipitate formation. The fluidic devices typically include channels that connect a reaction well to an inlet port and an outlet port, and a fluidic constriction channel that is configured to help retain fluids in the reaction well and/or promote mixing within the reaction well. In some aspect, fluidic devices are interconnected into fluidic assemblies that can be used in continuous process methods.

An improved reactor comprising a shell and at least one reactor internal component. The reactor internal component includes a tube bundle comprising a plurality of tubes attached by at least one tube support plate comprising at least one radial strut and at least one bracket configured to secure to at least one tube of the tube bundle. The tubes are arranged in concentric bands about a longitudinal axis of the reactor. The reactor comprises a gas inlet plate, a catalyst support plate, and a top plate.

The invention relates to an integrated process for assessing one or more properties of a catalyst. In the method, a standard chemical reactor or reactors is/are provided, and a bypass means is also provided, to transport a sample of whatever is added to the industrial reactor, to the test reactor. Both gases and liquids are transferred to the test reactor.

An improved reactor comprising a shell and at least one reactor internal component. The reactor internal component includes a tube bundle comprising a plurality of tubes attached by at least one tube support plate comprising at least one radial strut and at least one bracket configured to secure to at least one tube of the tube bundle. The tubes are arranged in concentric bands about a longitudinal axis of the reactor. The reactor comprises a gas inlet plate, a catalyst support plate, and a top plate.

Parallel uses of microfluidic methods and devices for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid are described. In some aspects, the present invention relates generally to flow-focusing-type technology, and also to microfluidics, and more particularly parallel use of microfluidic systems arranged to control a dispersed phase within a dispersant, and the size, and size distribution, of a dispersed phase in a multi-phase fluid system, and systems for delivery of fluid components to multiple such devices.