A device for generating a droplet array, which comprises a substrate, a roller on the substrate, and a microgrooved chip on the outer surface of the roller, wherein a sealant is on a surface of the substrate close to the roller and the microgrooved chip comprises a chip body fitted to the roller and an array of microgrooves arranged on the chip body, the array of microgrooves consisting of a plurality of microgrooves arranged at intervals on the chip body. When the roller rolls, liquid between the substrate and the roller enters the microgrooves and forms droplets while the microgrooved chip detaches from the roller and combines with the sealant which seals the microgrooves, generating a droplet array. The device generates a droplet array having uniform droplet size, good repeatability. Further, the method is simple and highly efficient, and has broad application prospects in the fields of medicine and biology.

A method of depositing single particles onto a target includes loading a particle suspension to a droplet dispenser having a suspension reservoir and a nozzle section, detecting particles in the nozzle section, testing a single particle condition of the droplet dispenser, and determining whether an ejection region of the nozzle section includes one single particle. The method further includes operating the droplet dispenser for dispensing a droplet such that the droplet is dispensed onto the target if the single particle condition is fulfilled, or the droplet is dispensed into a collection reservoir if the single particle condition is not fulfilled. The step of testing the single particle condition further includes determining whether a sedimentation region adjacent to the ejection region is free of particles. A dispenser for performing the method is also provided.

The disclosure relates to methods and systems for ultrahigh throughput protein synthesis and analysis.

A sequencer pretreatment device includes a suction and discharge mechanism, a nozzle head having a nozzle for mounting a dispensing tip, a container group for accommodating liquids including magnetic particle suspension, a moving mechanism for causing relative movement between the nozzle and the container group, and a magnetic unit that exerts a magnetic field to the mounted dispensing tip. A method includes an extraction step of mixing a sample, extraction reagent solution, and magnetic particle suspension in the container group and extracting nucleic acid, a fragmentation producing step of fragmentating the nucleic acid by mixing with fragmentation solution accommodated in the container group and producing a fragment of a base sequence having a molecular weight corresponding to a sequencer using magnetic particle suspension using the sequencer pretreatment device, and an amplification pretreatment step of dispensing a solution containing the fragment into the reaction vessel using the sequencer pretreatment device.

A drug processing system includes a workstation, at least one deck module movably positionable within the workstation, at least one filter plate operably coupled with the at least one deck module, an agitating member, and a liquid handler member. The at least one filter plate has a plurality of wells to receive a fluid therein. The agitating member is adapted to move the at least one filter plate according to an agitation system. The liquid handler member is adapted to selectively add a fluid to at least one of the plurality of wells and/or remove a fluid from the at least one of the plurality of wells according to a liquid handling system. The agitating member is adapted to move the at least one filter plate while the liquid handler member selectively adds and/or removes the fluid from the at least one of the plurality of wells.

The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.

The invention relates to an apparatus for analyzing reaction systems with a liquid phase (13) and a gas phase (15), the apparatus (1) comprising at least two tank reactors (3), a common feed line (5), a common drain line (25) for the liquid phase and a common drain line (21) for the gas phase, each tank reactor (3) being connected to the common feed line (5) by a supply line (7), to the common drain line (25) for the liquid phase by a liquid withdrawal line (27) and to the common drain line (21) for the gas phase by a gas withdrawal line (23), wherein the pressure in each tank reactor (3) is controlled by one of: (a) a pressure control (31) in the common feed line (5); (b) a pressure line (29) which is connected to the gas space of each tank reactor (3); (c) a pressure control (31) in the common drain line (21) for the gas phase and a flow restrictor (33) in the common drain line (25) for the liquid phase or a pressure control (31) in the common drain line (25) for the liquid phase and a flow restrictor (33) in the common drain line (21) for the gas phase; or (d) a pressure line (29) which enters into the common drain line (25) for the liquid phase or into the common drain line (21) for the gas phase.

The invention further relates to a process for analyzing reaction systems in such an apparatus.

Complete nucleic acid library preparation devices are provided. Aspects of the devices include: a thermal chip module comprising multiple nodes; one or more plate locations; a robotically controlled liquid handler configured to transfer liquid between the one or more plate locations and the thermal chip module; and a bulk reagent dispenser configured to access each node of the thermal chip module.

Complete nucleic acid library preparation devices are provided. Aspects of the devices include: a thermal chip module comprising multiple CLC reaction wells; one or more plate locations; a robotically controlled liquid handler configured to transfer liquid between the one or more plate locations and the thermal chip module; and a bulk reagent dispenser configured to access each CLC reaction well of the thermal chip module.

The invention features methods of making devices, or platens, having a high-density array of through-holes, as well as methods of cleaning and refurbishing the surfaces of the platens. The invention further features methods of making high-density arrays of chemical, biochemical, and biological compounds, having many advantages over conventional, lower-density arrays. The invention includes methods by which many physical, chemical or biological transformations can be implemented in serial or in parallel within each addressable through-hole of the devices. Additionally, the invention includes methods of analyzing the contents of the array, including assaying of physical properties of the samples.