A method of forming complex structures in a ceramic-, glass- or glass-ceramic-body microfluidic module is disclosed including the steps of providing at green-state refractory-material structure comprising least a portion of a body of a microfluidic module, providing a removeable insert formed of a carbon or of a carbonaceous material having an external surface comprising a negative surface of a desired surface to be formed in the microfluidic module, machining an opening in the green-state structure, positioning the insert in the opening, firing the green-state structure and the insert together, and after firing is complete, removing the insert. The insert is desirably a screw or screw shape, such that interior threads are formed thereby. The insert desirably comprises graphite, and the structure desirably comprises ceramic, desirably silicon carbide.

A continuous acoustic chemical microreactor system is disclosed. The system includes a continuous process vessel (CPV) and an acoustic agitator coupled to the CPV and configured to agitate the CPV along an oscillation axis. The CPV includes a reactant inlet configured to receive one or more reactants into the CPV, an elongated tube coupled at a first end to the reactant inlet and configured to receive the reactants from the reactant inlet, and a product outlet coupled to a second end of the elongated tube and configured to discharge a product of a chemical reaction among the reactants from the CPV. The acoustic agitator is configured to agitate the CPV along the oscillation axis such that the inner surface of the elongated tube accelerates the one or more reactants in alternating upward and downward directions along the oscillation axis.

The present invention relates to monolithic bodies, uses thereof and processes for the preparation thereof. Certain embodiments of the present invention relate to the use of a monolithic body in the preparation of a radioactive substance, for example a radiopharmaceutical, as part of a microfluidic flow system and a process for the preparation of such a monolithic body.

A silicon carbide flow reactor fluidic module comprises a monolithic closed-porosity silicon carbide body, a tortuous fluid passage extending through the silicon carbide body, the tortuous fluid passage having an interior surface, and one or more thermal control fluid passages also extending through the silicon carbide body, the interior surface having a surface roughness of less than 10 μm Ra. A process for forming such modules is also disclosed.

The invention providing methods of loading and unloading particulate from micorchannels in apparatus that contains multiple microchannels, typically apparatus that is designed to operate with hundreds or thousands of particulate-containing microchannels. Aligning a sonicating head at one end of a set of microchannels provides a particularly effective mode for densifying particulate in microchannels.

Provided herein are methods of making an adsorbent bed useful as a micro-reactor, or a catalytic and/or separation device. The adsorbent bed comprises a metal-organic framework composite. In the present methods, one or more metal-organic frameworks in powder form are mixed in a liquid to produce a metal-organic framework suspension or other type of metal-organic framework coating. A monolith is coated with the suspension or coating to provide the metal-organic framework composite having at least one metal-organic framework coating layer deposited on and bounded to the monolith. The metal-organic framework composite produced has a BET surface area of about 1 m.sup.2/g to about 300 m.sup.2/g and/or a comparative BET surface area of about 40% to about 100% relative to the metal-organic framework monolith, and pore size between about 1 nm and about 50 nm.

The present invention relates to a modular reactor system for carrying out processes comprising mixing, chemical reactions, heat exchange and/or separations, the reactor system comprising of at least one additive manufactured module, the module each performing at least one process unit operation, and optionally, an external housing.

The present invention concerns the field of microreaction devices and of micro-process engineering. It particularly involves devices having micro-channels (internal chambers of micrometric to submicrometric dimensions) for conveying chemical or biochemical mixtures and/or reactions. More specifically, such devices are optimized to achieve high temperature and pressure stresses (i.e. 500° C. and 500 bar). For observation and analysis purposes, the microreaction devices have a wide range of transparency in terms of wavelengths. The subject matter of the present invention relates to a microfluid or microreactor device made of transparent sapphire, preferably in the wavelength range of 150 to 6500 nm, its manufacturing method and to its use.

The present invention relates to monolithic bodies, uses thereof and processes for the preparation thereof. Certain embodiments of the present invention relate to the use of a monolithic body in the preparation of a radioactive substance, for example a radiopharmaceutical, as part of a microfluidic flow system and a process for the preparation of such a monolithic body.

A continuous acoustic chemical microreactor system is disclosed. The system includes a continuous process vessel (CPV) and an acoustic agitator coupled to the CPV and configured to agitate the CPV along an oscillation axis. The CPV includes a reactant inlet configured to receive one or more reactants into the CPV, an elongated tube coupled at a first end to the reactant inlet and configured to receive the reactants from the reactant inlet, and a product outlet coupled to a second end of the elongated tube and configured to discharge a product of a chemical reaction among the reactants from the CPV. The acoustic agitator is configured to agitate the CPV along the oscillation axis such that the inner surface of the elongated tube accelerates the one or more reactants in alternating upward and downward directions along the oscillation axis.