The present application concerns a microfluidic cassette for synthesizing a radiotracer including a microfluidic circuit in a support card that includes at least one intake for supply by a vial, at least one isotope port, at least one reaction chamber, at least one mixing chamber, at least one formulation chamber, and at least one connection for a syringe, linked together by capillaries. Also disclosed is a method for synthesizing a radiotracer in such a cassette.

Methods for monitoring catalytic chemical reactions are provided. Such a method may comprise (a) exposing a solid surface to conditions to induce a chemical reaction of reactants at an interface formed between the solid surface and a liquid crystal, wherein the solid surface catalyzes the chemical reaction and the liquid crystal is characterized by an anchoring orientation that changes during the chemical reaction; and (b) measuring the anchoring orientation of the liquid crystal at one or more time points and at one or more locations on the solid surface during step (a). Systems for carrying out the methods are also provided.

A catalytic microscale reactor with spiral reactor geometry may have a high surface area to volume ratio, high catalytic surface area, high heat transfer surface area, long residence time, and high single pass conversion. The catalytic surface may be treated with microsphere spacer particles which serve to maintain the space between them at an engineered distance without the need for precise manufacturing techniques. The design of the reactor may allow for a catalyst surface to be removed, uncoiled, refurbished, and recoiled in an automated continuous process. An automated continuous process may be suitable both for initially preparing a new catalytic surface as well as refurbishing a fouled catalytic surface and may reduce the time and cost to prepare a new surface.

A flow reactor has a module having a process fluid passage with an interior surface, a portion of the passage including a cross section along the portion having a cross-sectional shape, and a cross-sectional area with multiple minima along the passage. The cross-sectional shape varies continually along the portion and the interior surface of the portion includes either no pairs of opposing flat parallel sides or only pairs of opposing flat parallel sides which extend for a length of no more than 4 times a distance between said opposing flat parallel sides along the portion and the portion contains a plurality of obstacles distributed along the portion.

There is provided a master for micro flow path creation, a transfer copy, and a method for producing a master for micro flow path creation by which transfer copies having an area with high hydrophilicity can be easily mass-produced, the master for micro flow path creation including: a base material; a main concave-convex portion provided on a surface of the base material and extending in a planar direction of the base material; and a fine concave-convex portion provided on a surface of the main concave-convex portion and having a narrower pitch than the main concave-convex portion. The fine concave-convex portion has an arithmetic average roughness of 10 nm to 150 nm and has a specific surface area ratio of 1.1 to 3.0.

A flow reactor has a module having a process fluid passage with an interior surface, a portion of the passage including a cross section along the portion having a cross-sectional shape, and a cross-sectional area with multiple minima along the passage. The cross-sectional shape varies continually along the portion and the interior surface of the portion includes either no pairs of opposing flat parallel sides or only pairs of opposing flat parallel sides which extend for a length of no more than 4 times a distance between said opposing flat parallel sides along the portion and the portion contains a plurality of obstacles distributed along the portion.

A reactor includes a reaction-side flow passage through which a reaction fluid being a fluid constituting a reaction object flows; a temperature controller (heat-medium side flow passage) configured to heat or cool the reaction fluid from outside the reaction-side flow passage; and a catalyst configured to promote a reaction of the reaction fluid, the catalyst provided in the reaction-side flow passage so that a contact area with the reaction fluid is larger on a downstream side than on an upstream side in the reaction-side flow passage.

A catalytic microscale reactor with spiral reactor geometry may have a high surface area to volume ratio, high catalytic surface area, high heat transfer surface area, long residence time, and high single pass conversion. The catalytic surface may be treated with micro sphere spacer particles which serve to maintain the space between them at an engineered distance without the need for precise manufacturing techniques. The design of the reactor may allow for a catalyst surface to be removed, uncoiled, refurbished, and recoiled in an automated continuous process. An automated continuous process may be suitable both for initially preparing a new catalytic surface as well as refurbishing a fouled catalytic surface and may the time and cost to prepare a new surface.

A flow reactor has a module having a process fluid passage with an interior surface, a portion of the passage including a cross section along the portion having a cross-sectional shape, and a cross-sectional area with multiple minima along the passage. The cross-sectional shape varies continually along the portion and the interior surface of the portion includes either no pairs of opposing flat parallel sides or only pairs of opposing flat parallel sides which extend for a length of no more than 4 times a distance between said opposing flat parallel sides along the portion and the portion contains a plurality of obstacles distributed along the portion.

The present invention provides a micro-reactor (1) adapted to host chemical reactions having at least one microfluidic layer, said micro-reactor (1) comprising a fluid inlet (2) and a fluid outlet (3); a plurality of micro-reaction chambers (10) arranged in rows (7) and columns (6), each micro-reaction chamber comprising a chamber inlet (10a) and a chamber outlet (10b); a plurality of supply channels (4) for supplying fluid to from said fluid inlet (2) to said micro-reaction chambers (10) and further arranged for draining said micro-reaction chambers (10) to said fluid outlet (3), said supply channels (10) extending in a first direction (D1) along the columns (6) of micro-reaction chambers (10) and arranged such that there is one supply channel (4) between adjacent columns (6). The micro-reaction chambers (10) in the columns (6) are arranged such that the chamber inlets (10a) of a column are in fluid contact with the same supply channel (4) and the chamber outlets (10b) are in fluid contact with the supply channel (4) adjacent to the supply channel (4) arranged in fluidic contact with the chamber inlets (10a). Further, the plurality of supply channels (4) comprises a first end supply channel (4a) arranged for supplying fluid to a first end column (6a) of the micro-reaction chambers (10) and a second end supply channel (4b) arranged for draining fluid from the second, opposite, end column (6b) of said micro-reaction chambers (10); and wherein the micro-reactor (1) further comprises at least one reagent inlet (8) in fluid contact with the first end supply channel 4a and a reagent outlet (9) in fluid contact with the second end supply channel such that reagents introduced to the at least one reagent inlet (8) fill the plurality of micro-reaction chambers (10) in a second direction (D2) along the rows (7) of micro-reaction chambers (10) to the reagent outlet (9).