Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.

Modular reactors comprising a chassis, reactor tubing and optionally a cover are disclosed. The chassis comprises a plurality of channels of different lengths into which a length of reactor tubing is placed to create the reactor portion of the flow reactor.

Provided is a method of manufacturing a module structure for photomicro-reactors. The method of manufacturing a module structure for photomicro-reactors according to an aspect of the present invention, which is a method of manufacturing the module structure for photomicro-reactors inside which a reactant and a photocatalyst flow and photochemically react, includes mixing a polymer and a photoinitiator to prepare a photocurable resin, exposing one region of a surface of the photocurable resin to ultraviolet light to form a unit layer having a predetermined thickness, placing the photocurable resin on an upper side of the unit layer, and forming and stacking a plurality of the unit layers by repeatedly performing the forming of the unit layer and the placing of the photocurable resin to form the module structure.

The present application concerns a microfluidic cassette for synthesizing a radiotracer including a microfluidic circuit in a support card that includes at least one intake for supply by a vial, at least one isotope port, at least one reaction chamber, at least one mixing chamber, at least one formulation chamber, and at least one connection for a syringe, linked together by capillaries. Also disclosed is a method for synthesizing a radiotracer in such a cassette.

Modular reactors comprising a chassis, reactor tubing and optionally a cover are disclosed. The chassis comprises a plurality of channels of different lengths into which a length of reactor tubing is placed to create the reactor portion of the flow reactor.

Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.

Fluidic systems and methods in which oscillatory flow is employed are generally described. In some instances, one or more solenoids are used to drive the oscillation of a magnetically-susceptible body which creates oscillatory flow of a fluid in a fluidic channel in fluid communication with a channel containing the magnetically-susceptible body.

Disclosed herein is a device and method for changing the conditions of a solution flowing in a serial path. In particular, disclosed herein is a device that includes a chemical reactor, a first system, and a second system that are each serial to one another. Each of the first system and the second system include a mixing chamber, a solvent reservoir, a solvent pump, and one or more detectors. Also disclosed herein is a method for changing the condition of a solution that includes flowing a liquid sample in a path, serially mixing the sample with at least two discrete solvents while it flows through the path, and detecting the condition of the sample after it is mixed with each solvent.

The invention refers to a modular continuous flow device for automated chemical multistep synthesis under continuous flow conditions. The device comprises a plurality of different types of continuous flow modules and a valve assembly for connecting the continuous flow modules to each other in a parallel or radial manner. This arrangement allows conducting chemical reaction sequences by pre-synthesizing and intermediately storing or simultaneously synthesizing at least one intermediate product which is needed in the main synthetic reaction sequence in order to obtain the final product.

A modular reactor device has an outer housing, a reaction chamber, a fluid pathway connected to the reaction chamber, and a valve to control flow of fluid within the device. The outer housing has a plurality of connection ports including: a fluid input and a fluid output; an electrical input; and a pneumatic input. Either the electrical input or the pneumatic input is connected to the valve to provide for control of the valve, and either the fluid input or the fluid output is connected to the reaction chamber or the fluid pathway. Other aspects provide a base station for receiving and controlling a modular reactor device and methods for manufacturing the modular reactor device and for performing reactions using a modular reactor device.