A method for preparing (dimethylaminomethylene) malononitrile by using a micro reaction system. Cyanoacetamide, N,N-dimethylformamide and a catalyst are mixed to obtain a mixture, and the mixture and phosphorus oxychloride are simultaneously pumped into the micro reaction system that includes a micromixer and a microchannel reactor connected in series for continuous dehydration condensation. After adjusted to a target pH, the crude product is subjected to continuous liquid-liquid extraction with an organic solvent in a centrifugal extraction unit comprising a plurality of annular centrifugal extractors connected in series. The organic phase is collected to obtain the target product (dimethyl aminomethylene) malononitrile.

Parallel uses of microfluidic methods and devices for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid are described. In some aspects, the present invention relates generally to flow-focusing-type technology, and also to microfluidics, and more particularly parallel use of microfluidic systems arranged to control a dispersed phase within a dispersant, and the size, and size distribution, of a dispersed phase in a multi-phase fluid system, and systems for delivery of fluid components to multiple such devices.

Systems and methods taught herein enable simultaneous forward and side detection of light originating within a microfluidic channel disposed in a substrate. At least a portion of the microfluidic channel is located in the substrate relative to a first side surface of the substrate to enable simultaneous detection paths with respect to extinction (i.e., 0°) and side detection (i.e., 90°). The location of the microfluidic channel as taught herein enables a maximal half-angle for a ray of light passing from a center of the portion of the microfluidic channel through the first side surface to be in a range from 25 to 90 degrees in some embodiments. By placing at least the portion of the microfluidic channel proximate to the side surface of the substrate, a significantly greater proportion of light emitted or scattered from a particle within the microfluidic channel can be collected and imaged on a detector as compared to conventional particle processing chips.

The invention providing methods of loading and unloading particulate from micorchannels in apparatus that contains multiple microchannels, typically apparatus that is designed to operate with hundreds or thousands of particulate-containing microchannels. Aligning a sonicating head at one end of a set of microchannels provides a particularly effective mode for densifying particulate in microchannels.

A microreactor system includes: a microreactor that has two inflow ports into which fluids are introduced and a flow path configured to merge the fluids, and that is configured to mix a first fluid introduced from one of the inflow ports and a second fluid introduced from the other of the inflow ports in the flow path; a first container in which the first fluid is prepared; a second container in which the second fluid is prepared; a first pump configured to feed the first fluid toward the inflow port; a second pump configured to feed the second fluid toward the inflow port; first and second measurement units configured to measure amounts of the first fluid and the second fluid, respectively; and switching units configured to switch at least one of the first fluid and the second fluid to be fed to the microreactor.

A microfluidics-based nanoparticle synthesis system, a device and a synthesis method thereof are provided. The nanoparticle synthesis system comprises: a microfluidic chip; a reagent bottle which is connected with the microfluidic chip; and a flow control assembly comprising a pressure controller which is used for controlling the pressure in the reagent bottle. The system achieves high-accuracy flow control, and a microfluidic chip that can achieve high-efficiency and rapid mixing is also used in combination to finally achieve high-throughput and high-uniformity nanoparticle synthesis. A user may adjust the same instrument as required to achieve different throughputs without redesigning the instrument.

A microfabricated sheath flow structure for producing a sheath flow includes a primary sheath flow channel for conveying a sheath fluid, a sample inlet for injecting a sample into the sheath fluid in the primary sheath flow channel, a primary focusing region for focusing the sample within the sheath fluid and a secondary focusing region for providing additional focusing of the sample within the sheath fluid. The secondary focusing region may be formed by a flow channel intersecting the primary sheath flow channel to inject additional sheath fluid into the primary sheath flow channel from a selected direction. A sheath flow system may comprise a plurality of sheath flow structures operating in parallel on a microfluidic chip.

The disclosed invention relates to a method for restarting a synthesis gas conversion process which has stopped. The synthesis gas conversion process may be conducted in a conventional reactor or a microchannel reactor. The synthesis gas conversion process may comprise a process for converting synthesis gas to methane, methanol or dimethyl ether. The synthesis gas conversion process may be a Fischer-Tropsch process.

A microparticle producing system using microfluidics and a controlling method thereof, and specifically, to a microparticle producing system that may stably transport droplets produced using microfluidics without agglomeration or destruction, compared to the conventional art, and a method of controlling the microparticle producing system to transport the droplets more stably in the microparticle producing system. By the microparticle producing system and the controlling method thereof, which are disclosed herein, droplets produced by the microparticle producing system using microfluidics may be stably transported without agglomeration or destruction, resulting in more effective microparticle production.

A method is for synthesizing an oxetane compound by a microreactor. The synthesis method includes: introducing trimethylolpropane and carbonate into the microreactor in the presence of an alkaline catalyst, and synthesizing the oxetane compound by means of a micro-reaction continuous flow process under an inert solvent or a solvent-free condition. Compared with conventional reactors, the microreactor has the advantages of being high in heat transfer mass transfer coefficient, good in mixing performance, easy to control in temperature, safe and controllable in process. The three oxetane products are produced by utilizing the advantages of the microreactor, thereby greatly improving the mass transfer heat transfer performance of a reaction system, shortening the reaction time, improving the production efficiency, particularly avoiding the long-time high-temperature process in the pyrolysis process, reducing the production of high-boiling-point by-products, improving the yield, realizing continuity and automation of the process, and improving process safety.