The present invention provides a system for the production of a radiopharmaceutical including a radiosynthesis apparatus and a disposable cassette. The system of the invention includes a device that enables a position on the cassette to be freed for inclusion of an additional reagent vial. With the system of the invention a broader range of radiochemical syntheses can be envisaged using the cassette.

The present invention relates to an automated radiosynthesis device adapted for the addition of multiple additional components. The automated radiosynthesis device of the invention enables a wider range of radiochemical synthetic processes to be carried out in an automated fashion.

Methods for monitoring catalytic chemical reactions are provided. Such a method may comprise (a) exposing a solid surface to conditions to induce a chemical reaction of reactants at an interface formed between the solid surface and a liquid crystal, wherein the solid surface catalyzes the chemical reaction and the liquid crystal is characterized by an anchoring orientation that changes during the chemical reaction; and (b) measuring the anchoring orientation of the liquid crystal at one or more time points and at one or more locations on the solid surface during step (a). Systems for carrying out the methods are also provided.

A microparticle producing system using microfluidics and a controlling method thereof, and specifically, to a microparticle producing system that may stably transport droplets produced using microfluidics without agglomeration or destruction, compared to the conventional art, and a method of controlling the microparticle producing system to transport the droplets more stably in the microparticle producing system. By the microparticle producing system and the controlling method thereof, which are disclosed herein, droplets produced by the microparticle producing system using microfluidics may be stably transported without agglomeration or destruction, resulting in more effective microparticle production.

Disclosed herein is a device and method for changing the conditions of a solution flowing in a serial path. In particular, disclosed herein is a device that includes a chemical reactor, a first system, and a second system that are each serial to one another. Each of the first system and the second system include a mixing chamber, a solvent reservoir, a solvent pump, and one or more detectors. Also disclosed herein is a method for changing the condition of a solution that includes flowing a liquid sample in a path, serially mixing the sample with at least two discrete solvents while it flows through the path, and detecting the condition of the sample after it is mixed with each solvent.

Fluid reactors include a sealed housing enclosing a reactor core that includes at least one substrate-free multichannel reactor core element. Each reactor core element is made from a non-substrate mounted, open pore cellular network material having an asymmetric, tortuous, bi-continuous two-phase material structure and contains multiple perforating fluid channels. Multiple reactor core elements can be serially and/or parallelly piped in a sealed manner to form a reactor core for a fluid reactor with a higher production capacity.

A device for synthesizing a radioisotope-labelled target tracer includes a microfluidic chip having an SCX module configured to concentrate and capture a radioisotope from a radioisotope solution and release the captured radioisotope therefrom, an SAX module configured to purify the released radioisotope from the SCX module, and an passive in-plane mixing/reaction module configured to mix the purified radioisotope with a target precursor and perform labelling reaction to synthesize the radioisotope-labelled target tracer therein. The device also includes a heating means positioned in relation to the microfluidic chip for heating the microfluidic chip during the labelling reaction; and a first valve fluidically coupled with the SCX and SAX modules and a second valve fluidically coupled with the SAX module and the in-plane mixing/reaction module for operably controlling transit of various substances or mixtures among the SCX module, the SAX modules and the in-plane mixing/reaction module.

A microparticle producing system using microfluidics and a controlling method thereof, and specifically, to a microparticle producing system that may stably transport droplets produced using microfluidics without agglomeration or destruction, compared to the conventional art, and a method of controlling the microparticle producing system to transport the droplets more stably in the microparticle producing system. By the microparticle producing system and the controlling method thereof, which are disclosed herein, droplets produced by the microparticle producing system using microfluidics may be stably transported without agglomeration or destruction, resulting in more effective microparticle production.

Disclosed herein is a device and method for changing the conditions of a solution flowing in a serial path. In particular, disclosed herein is a device that includes a chemical reactor, a first system, and a second system that are each serial to one another. Each of the first system and the second system include a mixing chamber, a solvent reservoir, a solvent pump, and one or more detectors. Also disclosed herein is a method for changing the condition of a solution that includes flowing a liquid sample in a path, serially mixing the sample with at least two discrete solvents while it flows through the path, and detecting the condition of the sample after it is mixed with each solvent.

An apparatus includes a substrate having a recess and a multitude of particles arranged in the recess. A first portion of the particles is joined to a porous structure by means of a coating. A second portion of the particles is not joined by means of the coating. The first portion of the particles is arranged closer to an opening of the recess than the second portion of the particles so that a leaking of the second portion of the particles from the recess through the opening is prevented.