The present invention relates to an automated radiosynthesis device adapted for the addition of multiple additional components. The automated radiosynthesis device of the invention enables a wider range of radiochemical synthetic processes to be carried out in an automated fashion.

Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.

A reaction processor is provided with a reaction processing vessel in which a channel is formed, a liquid feeding system, a temperature control system for providing a high temperature region and a low temperature region to the channel, and a fluorescence detector for detecting the sample passing through a fluorescence detection region of the channel, and a CPU for controlling the liquid feeding system based on a signal that is detected. A target stop position X.sup.[L].sub.0(n+1) of the sample in the low temperature region in an (n+1)th cycle is corrected from a target stop position X.sup.[L].sub.0(n) of the sample in the low temperature region in the nth cycle based on the result of stopping control on the sample in the nth cycle.

The invention relates to a device for synthesising oligonucleotides, comprising: a reagent container receptacle (1) for holding a reagent container support (17) comprising multiple reagent containers (18); an exchangeable microfluid chip (10) comprising a synthesis chamber, fluid connectors and microfluid valves; a control device (5); fluid connecting means (2); wherein the device can be loaded with the microfluid chip (10) and the reagent container support (17) when in a loading position; a chip receptacle (3). To allow cost-effective and prompt synthesis even of small amounts of oligonucleotides, the invention provides for an actuator device (6) to be provided, with which the reagent container receptacle (1), the microfluid chip (10) and the fluid connecting means (2) can be brought from the loading position to an operating position, in which operating position the reagent container receptacle (1), the chip receptacle (3) and the fluid connecting means (2) are positioned relative to each other such that reagents can be conveyed out of the reagent containers (18) towards the synthesis chamber (14) depending on the valve position of the microfluid valves.

A microfluidic chip device for the purification of radiochemical compounds includes a chip having an injection channel and intersecting branch channels with a plurality of valves are located along the injection channel and branch channels and configured to retain a plug of solution containing the radiochemical compound. The chip further includes a serpentine channel segment (for separation) coupled to the output of the injection channel. A high voltage power source advances the plug of solution through the purification region and into the downstream fraction collection channel. The chip includes a downstream fraction collection channel coupled to the serpentine channel segment and having an optical and radiation detection regions. One or more branch fraction channels intersect with the fraction collection channel and include valves located therein so that the radiochemical compound that is detected using a radiation detector is directed into the desired branch fraction channel for subsequent use.

Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.

A channel assembly is disclosed, which may comprise a microfluidic channel. Methods of manufacture are also disclosed as are detectors and detector components which may comprise such a channel assembly. An example is a detection apparatus comprising: a detector for detecting a substance of interest; and a pneumatic system comprising a microfluidic channel assembly comprising a first microfluidic channel for dispensing vapour to the detector, wherein the first microfluidic channel comprises a groove in a surface of a polymer body and a wall of the first channel is provided by a film bonded to the surface of the body over the groove.

A pressure sensor (100) for a measuring system (10) measuring concentrations of gaseous and/or aerosol components of a gas mixture with a reaction carrier (14), with a flow channel (42). The flow channel (42) forms a reaction chamber (46) with a reactant (48), that enters into an optically detectable reaction, and with a measuring device (12) with a gas port unit (5) connecting an inlet channel (16) and an outlet channel (18) to the flow channel (42) and a gas delivery unit (28). The pressure sensor (100) measures a pressure difference of a gas mixture flowing through the gas delivery assembly unit (2) and/or the flow channel (42) of the reaction carrier (14) and has an elastic element (102), which is configured to undergo deformation as a function of the pressure difference. A measuring method, a measuring device and a reaction carrier for such a measuring system are also provided.

Disclosed herein are chemical actuators and ionic motive force transducers. The actuators and transducers are capable of converting an electrical stimulus into an ionic gradient within a reaction volume.

Methods are disclosed for operating devices in diffusion-limited regimes, where diffusion rates are sufficiently low that device operation can be optimized by taking the rate of diffusion into account when directing devices what actions to take.