The invention relates to membranes for separation, removal, and/or concentration purposes. The object of the invention is the simple and reliable adsorption of the molecules and to simplify the desorption of target molecules that are adsorbed and chromatographically bonded on membranes, preferably without the addition of substances with a high ion content, such as acids, alkalis or salts. The object of the invention is also to develop a value that can be easily measured, which allows for an indication of the current and/or remaining binding capacity of the membrane during the adsorption process and/or the control thereof. The adsorption takes place on a charged membrane and desorption is achieved using physical, electromagnetic and/or the generation of electrical fields. This is carried out with a thin metal layer being applied to one or both sides of a positively or negatively charged membrane and a voltage is applied for desorption.

The present invention relates to a flow-through device comprising at least one separation column wherein a first packing component, which comprises particles of alumina and/or silica, and a second packing component, which comprises a powder of one or more hygroscopic salts are provided. The two packing components may be blended or layered in the device, which may comprise a single tube or a plurality of tubes arranged in a plate format, such as the wells of a multiwall plate or tubes in a rack. In addition, the invention relates to a method for removing one or more matrix components, such as pigments, from a biological sample, by passing said sample across a first packing component, which comprises particles of alumina and/or silica, and a second packing component, which comprises a powder of one or more hygroscopic salts.

This invention employs columns and methods to apply external and internal standards and compounds. Analytical standard or compounds are adsorbed to a solid phase extraction media and are stored indefinitely. The standards or compounds remain stable on the solid phase extraction media without decomposing. The standards or compounds may be removed from the solid phase extraction media with a solvent.

The present invention relates to a flow-through device comprising at least one separation column wherein a first packing component, which comprises particles of alumina and/or silica, and a second packing component, which comprises a powder of one or more hygroscopic salts are provided. The two packing components may be blended or layered in the device, which may comprise a single tube or a plurality of tubes arranged in a plate format, such as the wells of a multiwall plate or tubes in a rack. In addition, the invention relates to a method for removing one or more matrix components, such as pigments, from a biological sample, by passing said sample across a first packing component, which comprises particles of alumina and/or silica, and a second packing component, which comprises a powder of one or more hygroscopic salts.

The present disclosure is directed to surface modified materials such as stationary phase materials for performing size exclusion chromatography. Aspects of the present disclosure feature materials surface modified with a moiety including a polyethylene glycol (PEG) functionality and a moiety comprising a diol functionality. Such surface modified materials exhibit a reduced propensity for ionic and hydrophobic secondary interactions.

This invention employs columns and methods to apply external and internal standards and compounds. Analytical standard or compounds are adsorbed to a solid phase extraction media and are stored indefinitely. The standards or compounds remain stable on the solid phase extraction media without decomposing. The standards or compounds may be removed from the solid phase extraction media with a solvent.

A reversible enrichment material, its preparation and application thereof are provided. The reversible enrichment material includes an inorganic carrier; and an active metal salt, a first metal salt promoter and a second metal salt promoter supported on the inorganic carrier. The active metal salt is a soluble silver salt, a soluble copper salt, or a combination thereof. The first metal salt promoter is one or more selected from the group consisting of soluble salts of Group IA, Group IIA and Group IIIA metals, and the second metal salt promoter is one or more selected from the group consisting of soluble salts of transition metals other than Group IB metals. The reversible enrichment material can realize effective separation of saturated hydrocarbon from unsaturated hydrocarbon and has good reversibility.

Disclosed is a sample pretreatment method of microextraction tube injection, comprising providing a capillary micro-extraction tube with extracting medium in it as an injector, passing a sample through the capillary micro-extraction tube, during which an analyte is extracted into an extracting medium inside the capillary micro-extraction tube; then, filling the capillary micro-extraction tube with an organic solvent and keeping the filling for a certain period of time, so that the extracted analyte is dissolved in the organic solvent inside the capillary micro-extraction tube to form an injection solution; finally, keeping one end of the capillary micro-extraction tube sealed and inserting the other end directly into an injection port of a gas chromatography, such that the injection solution is automatically ejected out from the capillary micro-extraction tube into the injection port.

An insulin infusion set (IIS) device with one or more features designed to achieve longevity in a patients continuous subcutaneous insulin infusion (CSII) site viability. One exemplary feature is an adsorbent material configured to adsorb phenolic excipients (e.g., m-cresol or other preservatives) from the insulin formulation. The adsorbent material may be positioned along a fluid pathway specifically designed to increase and/or extend exposure between the insulin formulation and the adsorbent material. Another exemplary feature is a medicament configured to reduce the patients inflammation or slow the progression of the patients inflammatory response. Yet another exemplary feature is a diffusive catheter configured to deliver the insulin formulation in a diffuse manner.

Certain embodiments described herein are directed to systems and methods that can be used to analyze species in a fluid stream. In some configurations, a sorbent tube effective to directly sample aromatics and/or polyaromatics in a fluid stream is described.