The present inventive concept relates to a microfluidic arrangement (1) for capillary driven fluidic connection between capillary flow channels (8, 16). The microfluidic arrangement (1) comprises: a first microfluidic system (4) comprising a first surface (5), and a first capillary flow channel (8), wherein the first capillary flow channel (8) has an elongation in a first plane, and the first surface comprises an outlet opening (9) in a plane different from the first plane, the outlet opening defining an outlet area (35) in the first surface and being adapted to allow fluidic communication with the first capillary flow channel thereby forming a flow outlet (12) of the first capillary flow channel, and a second microfluidic system (6) comprising a second surface (7) and a second capillary flow channel (16), wherein the second capillary flow channel (16) has an elongation in a second plane parallel to the first plane, and a portion of the second surface (7) comprises an inlet opening (13) in a plane different from the second plane, the inlet opening defining an inlet area (33) in the second surface and being adapted to allow fluidic communication with the second capillary flow channel thereby forming a flow inlet (20) of the second capillary flow channel, wherein the first microfluidic system (4) and the second microfluidic system (6) are arranged with the first and the second surfaces in contact such that the flow outlet (12) and the flow inlet (20) are interfaced, thereby allowing capillary driven fluidic connection between the first and the second capillary flow channels (8, 16), wherein the outlet area (35) overlaps at least a portion of the inlet area (33), said at least a portion of the inlet area (33) overlapped by the outlet area (35) being smaller than the outlet area (35).

Flow cell assemblies and related reagent selector valves. In accordance with an implementation, an apparatus includes a system including a reagent cartridge receptacle. The apparatus includes a flow cell assembly. The apparatus includes a reagent cartridge receivable within the reagent cartridge receptacle. The reagent cartridge including a plurality of reagent reservoirs. The apparatus includes a manifold assembly. The manifold assembly including a reagent selector valve adapted to be fluidically coupled to the reagent reservoirs and to selectively flow reagent from a corresponding reagent reservoir to the flow cell assembly. At least a surface of the manifold assembly associated with the reagent selector valve is coupled to a portion of the flow cell assembly.

A flameless thermal oxidizer (FTO) includes at least one baffle constructed and arranged in a reaction chamber of the FTO to coact with a diptube of the FTO to radially expand a resulting “bubble” or reaction envelope from the diptube outward into a porous matrix of the FTO. A related method is also provided.

A device for performing in situ genetic analyses, conformed so as to be transportable manually by a user, which comprises a casing defining an internal compartment and a plurality of analysis units arranged in the internal compartment, where each analysis unit is configured to perform a respective and independent genetic analysis of at least one sample; each analysis unit comprises a sample holder compartment accessible by the user and adapted to accommodate at least one sample; a command and control unit; at least one sensor selected among an optical, acceleration, temperature, pressure, motion, chemical sensor or a combination thereof, configured to detect a first physical quantity relative to the genetic analysis of the at least one sample and to transduce the first physical quantity into a first signal which is indicative of the state of progress of the genetic analysis, the command and control unit is in signal communication with the at least one sensor for receiving said first signal; the analysis unit further comprises a plurality of instruments, configured to perform the genetic analysis of the sample, comprising an amplification and optical detection device configured to detect at least a second physical quantity relative to the genetic analysis and to transduce the second physical quantity into at least a second signal which is indicative of the outcome of the genetic analysis, the command and control unit is in signal communication with the amplification and optical detection device for receiving said second signal; the device further comprises a processing unit, in signal communication with the command and control unit of each analysis unit for receiving the respective first signals and the respective second signals.

The single-use disposable spectrophotometer described herein can measure one or more blood chemistry analytes from a drop of whole blood. A passive filtration system takes whole blood and delivers plasma along with a dissolved reporter molecule to one or more spectrophotometers which can operate with narrow band optical spectrum centered on an optical detection frequency. The spectrophotometer detects the changes in absorption of the plasma as a result of a chemistry reaction to determine the concentration or activity of one or more analytes.

An expandable array and methods of maintaining a biological sample within an expandable array are provided. The expandable array includes a plurality of receptacles configured to receive a biological sample and a plurality of beams comprising a programmable material. Each beam of the plurality of beams is located between and connects at least two receptacles. The programmable material can be a shape-memory polymer or a magnetoactive material that transitions the plurality of beams from an extended state to a contracted state upon application of a stimulus.

Provided herein are systems, devices and methods for performing multianalyte detection in a biological sample, such as a human blood sample. Multiwell plates useful for performing multianalyte detection are also provided. The systems, devices and methods provided herein relate to the field of direct-to-consumer diagnostics (DTC diagnostics) and are useful, e.g., for facilitating consumer access to consumer healthcare and consumer wellness information. Other uses of the systems, devices and methods provided herein relate to the fields of medical research and drug discovery.

Modular active surface devices for microfluidic systems and methods of making the same including adhesive-free assembly are disclosed. In some embodiments, the presently disclosed modular active surface devices and methods provide adhesive-free assembly processes, such as, but not limited to, laser beam welding (LBW) processes, ultrasonic welding processes, heat welding processes, chemical bonding processes, mechanical compression processes, and the like. In some embodiments, the modular active surface devices and methods provide a reagent hopper or well that is out-of-plane with the reaction chamber.

The invention concerns an analyte meter (10) for medical tests having a meter housing (12), a strip port (14) mounted in an opening of the meter housing (12) and configured to receive a measuring part of a test strip (18), and a sealing insert (16) which is arranged within the strip port (14) and provides an insertion path for the test strip (18). For improved screening against contamination, it is proposed that the sealing insert (16) comprises a plurality of sealing elements (42) which are arranged consecutively along the insertion path, wherein each of the sealing elements (42) has a slit (46) that forms a sealed aperture for the test strip (18) to pass through.

A pipette tip system for use with a plurality of pipette tips is disclosed that includes a support card connected to a base, wherein the base comprises an interlocking structure constructed to mate with an adjacent base. This unique base can be used with the several embodiments disclosed herein.