The present invention provides an apparatus for detecting the presence or absence of an analyte in liquid sample, including: a collection chamber, including an opening for collecting a liquid sample; a testing element for testing the analyte in liquid sample; and a cover for covering the opening of the collection chamber; wherein the apparatus further includes a prompting device for prompting if the cover is covered to a specified location, and the prompting device shall at least includes a first element and a second element, the first element is in contact with the second element, wherein one element vibrates to produce a sound. In some preferred ways, the second element produces friction with the first element, to cause one of the elements to generate vibrations. The apparatus in the present invention can allow the prompting sound to be clear and loud.

Digital microfluidic (DMF) methods and apparatuses (including devices, systems, cartridges, DMF readers, etc.), and in particular DMF apparatuses and methods that may be used to safely manually add or remove fluid within a cartridge while it is actively applying DMF. Also described herein are DMF readers for use with a DMF cartridges, including those including multiple and/or redundant safety interlocks. Also described herein are DMF reader devices having a cover with active control of microfluidics on the cover while actively controlling DMF on the reader base.

A system for releasing analytes contained within a sample. The system comprises a housing enclosing an interior space. The system additionally comprises a sample holder having at least one receptacle configured to receive a sample containing analytes bound within the sample. The system further includes at least one light emitting diode configured to generate light sufficient to separate photo-cleavable bonds binding the analytes within the sample.

A collection bottle that emits light once the lid of the bottle is rotated to its complete closed position is disclosed. An annular chamber concentric to the inner chamber of the collection bottle contains a dye such as fluorophor, a base catalyst, and diphenyl oxalate. A containment device is disposed in the annular chamber. The containment device holds one or more glass or other fragile material encasing vials containing hydrogen peroxide. The containment device is disposed in the vicinity of the bottle screw threads such that when the lid is completely screwed onto the collection bottle, a detent that is disposed above the superior lid screw thread compresses the exterior wall of the annular chamber and containment device, causing rupture of the vial(s) and allowing the hydrogen peroxide disposed therein to mix with the dye, base catalyst and diphenyl oxalate in the annular chamber. The subsequent chemical reaction causes the emission of light, visually indicating full closure of the lid on the collection bottle.

A container (30) includes a plurality of accommodation portions (310) accommodating the sample, and a lid portion (320) closing the plurality of accommodation portions (310). The treatment apparatus (6) includes a container support portion (41) configured to support the plurality of accommodation portions (310), and a container fixing portion (42) configured to overlap the lid portion (320). The container fixing portion (42) is configured to sandwich the container (30) together with the container support portion (41). The container fixing portion (42) is provided in a manner of being able to be opened and closed with respect to the container support portion (41). A plurality of hole portions (411) are provided in the container support portion (41). A plurality of hook portions (420) inserted into the plurality of hole portions (411) and engaging with edge portions (411a) of the plurality of hole portions (411) are provided in the container fixing portion (42).

A collection bottle that emits light once the lid of the bottle is rotated to its complete closed position is disclosed. An annular chamber concentric to the inner chamber of the collection bottle contains a dye such as fluorophor, a base catalyst, and diphenyl oxalate. A containment device is disposed in the annular chamber. The containment device holds one or more glass or other fragile material encasing vials containing hydrogen peroxide. The containment device is disposed in the vicinity of the bottle screw threads such that when the lid is completely screwed onto the collection bottle, a detent that is disposed above the superior lid screw thread compresses the exterior wall of the annular chamber and containment device, causing rupture of the vial(s) and allowing the hydrogen peroxide disposed therein to mix with the dye, base catalyst and diphenyl oxalate in the annular chamber. The subsequent chemical reaction causes the emission of light, visually indicating full closure of the lid on the collection bottle.

A microfluidic device includes an inlet port configured to receive a sample, a first reaction chamber fluidically coupled to the inlet port, a first pump fluidically coupled to the inlet port, a second pump fluidically coupled to a mixing chamber, a metering channel fluidically coupled to the first reaction chamber and to the mixing chamber, and one or more second reaction chambers fluidically coupled to the mixing chamber. The first pump is configured to move fluid from the inlet port to the first reaction chamber and from the first pump to the inlet port. The second pump is configured to move fluid from the second pump to the mixing chamber, from the first reaction chamber to the mixing chamber, and from the mixing chamber to the one or more second reaction chambers.

Used for running a polymerase chain reaction, a thermal cycler includes a main body having a chamber, and inside of the chamber is provided with a protocol running device port and a sample block for placing reaction tubes. When a protocol running device is put into the protocol running device port, the main body may execute a thermal cycle onto the reaction tubes according to a protocol stored in the protocol running device.

A disclosed technique includes an assembly comprising a cup with a first visual sealing indicator and a lid with a second visual sealing indicator wherein, in operation, the lid is screwed on the cup to a sealing indicator position where the first visual sealing indicator and the second visual sealing indicator are aligned. Another disclosed technique includes an assembly comprising a cup with a first audible sealing indicator and a lid with a second audible sealing indicator wherein, in operation, the lid is screwed on the cup to a position past where the first audible sealing indicator and the second audible sealing indicator have contacted each other producing an audible sound. Another disclosed technique includes a cup with a raised central bottom area and an insert with bracing wings wherein, in operation, the bracing wings stabilize and secure the insert in the cup.

An apparatus for manipulating magnetic particles includes a latch mechanism. The latch mechanism has a pivoting part provided on a door and an engaging part provided on a main body. In the apparatus for manipulating magnetic particles, a first contact portion of a latch engages with the engaging part at a contact point in a state that the door is closed. The contact point is located more outside of the main body than the pivot axis. Accordingly, in a case where an external force is applied to the door in a direction to open the door in a state that the door is closed, a force is applied from the engaging part to the first contact portion, thereby generating a rotational force in a C direction to the pivoting part. As a result, in the state that the door is closed, it is possible to suppress the door from being opened without a manipulation by the user.