Provided is a genome extraction device including a safety clip combined with an inner chamber, more particularly a genome extraction device to which the above-described dual chamber structure is applied so that the genome extraction device can be stored stably for a long time without the risk of reagent leakage and an inner chamber is moved up and down by way of vibration generated during a production and distribution process of a product so that a sealing member for sealing upper openings and lower openings of the inner chamber can be prevented from being perforated.

A pipette for use with a pipette tip includes a chassis. An apparatus is coupled to the chassis and is configured to detachably hold at least one pipette tip. A drive apparatus is coupled to the chassis and is configured to displace a displacement element to suck liquid specimens into the pipette tip and eject the specimens from the pipette tip. A tubular pipette housing is configured to surround and connect to the chassis. The longitudinal direction of the chassis is aligned in the longitudinal direction of the pipette housing. The chassis includes multiple chassis elements which are arranged behind one another and are connected to one another. The apparatus for detachably holding at least one pipette tip and the drive apparatus are connected to one or more of the multiple chassis elements.

The present invention is, in combination, a bone marrow isolation tube and a centrifuge tube. The combination includes a centrifuge tube which defines a tube cavity and includes an upper cylindrical section connected to a lower tapered section which terminates at a bottom reservoir. The isolation tube is adapted to be received within the centrifuge tube cavity. The isolation tube includes a body with a tubular shaped outer surface wherein the interior of the isolation tube defines a lumen which includes an upper cylindrical lumen section and a lower conical lumen section terminating at an orifice. The isolation tube includes at least one wing extending radially outward from the outer surface of the isolation tube. The wing is configured to make contact with the interior surface of the centrifuge tube and wedge the isolation tube into the tapered section of the centrifuge tube during centrifuging. The present invention is also, in combination, a bone marrow isolation tube and a centrifuge tube. The centrifuge tube defines a tube cavity and includes at least two support members defining an insertion space and attached to the interior surface in an upper cylindrical section, the upper cylindrical section connected to a lower tapered section which terminates at a bottom reservoir. The isolation tube is adapted to be received within the insertion space with a flange that is configured to make contact with the support members of the centrifuge tube thereby wedging the isolation tube into the insertion space of the centrifuge tube during centrifuging.

A point of use analyzer includes pump, valve, port, and storage channel. The storage channel may hold multiple assay packets composed of reagent aliquots separated by bounding slugs. The storage channel may define an elongated lumen having two ends with each of the ends coupled to the valve. A sampling device for use with the analyzer engages the port and may include a recurrent coaxial tube having a separation medium. A method of using the analyzer with the sampling device includes steps of pumping a fluid to displace a sample into the separation medium and out through the opposed connection.

A fluid collection system comprises a sealed reagent container that fits inside a sample container and is unsealed by disengaging a seal comprised in a sample container. The sealed reagent container contains a reagent, such as a nucleic acid preservative. The reagent container also includes a sleeve disposed opposite the sealed opening. The sleeve includes a distal opening for receiving a sample and a proximal opening disposed in the sample container for guiding a sample from the distal opening and through the proximal opening into the sample container. Disengaging the seal releases the reagent into the sample container with the sample, where they mix.

Provided is a genome extraction device to which a dual chamber structure of an outer chamber and an inner chamber is applied, more particularly a genome extraction device to which the above-described dual chamber structure is applied so that the genome extraction device can be stored stably for a long time without the risk of reagent leakage.

A flow cell that includes (a) a gasket interposed between a first substrate and a second substrate, wherein the gasket, the first substrate and the second substrate are impermeable to aqueous liquid and liquid adhesive, wherein the gasket has a footprint on the first substrate that delineates a channel for containing the aqueous liquid; (b) a via in the gasket, the via containing a solidified liquid adhesive that bonds the first substrate to the second substrate, wherein the solidified liquid adhesive in the via is separated from the channel by the gasket; and (c) a channel port connecting the channel to the exterior of the flow cell, wherein the channel port is permeable to the aqueous liquid.

The invention relates to a substrate for testing samples, in particular cells or molecules, wherein the substrate comprises a fluid system comprising a sample chamber configured in the substrate for storing and testing samples and at least one liquid reservoir in fluid communication with the sample chamber, and wherein the substrate comprises a passive blocking element capable of assuming a closed position and an open position, wherein in the closed position a fluid exchange between the sample chamber and the liquid reservoir is blocked.

The application relates to microfluidic apparatus and methods of use thereof. Provided in one example is a microfluidic device comprising: a first fluidic input and a second fluidic input; and a fluidic intersection channel to receive fluid from the first fluidic input and the second fluidic input, wherein the fluidic intersection channel opens into a first mixing chamber on an upper region of a first side of the first mixing chamber, wherein the first mixing chamber has a length, a width, and a depth, wherein the depth is greater than about 1.5 times a depth of the fluidic intersection channel; an outlet channel on an upper region of a second side of the first mixing chamber, wherein the outlet channel has a depth that is less than the depth of the first mixing chamber, and wherein an opening of the outlet channel is offset along a width of the second side of the first mixing chamber relative to the fluidic intersection.

The present invention relates to a lectin-macromolecular carrier coupling complex for separating glycosylated exosomes from a clinical sample, which comprises a macromolecular carrier and lectins coupled to the outer side of the macromolecular carrier. The complex may simply, conveniently, rapidly, and accurately separate glycosylated exosomes from a clinical sample with a high separation efficiency and a good repeatability; and the separated exosomes are intact in morphology without rupturing or cracking, may be directly used for liquid detection of glycosylated exosomes, or directly used for immunology-related detection, or directly used for gene detection or analysis after extracting related nucleic acids from the exosomes.