Systems and methods for conducting designated reactions utilizing a base instrument and a removable cartridge. The removable cartridge includes a fluidic network that receives and fluidically directs a biological sample to conduct the designated reactions. The removable cartridge also includes a flow-control valve that is operably coupled to the fluidic network and is movable relative to the fluidic network to control flow of the biological sample therethrough. The removable cartridge is configured to separably engage a base instrument. The base instrument includes a valve actuator that engages the flow-control valve of the removable cartridge. A detection assembly held by at least one of the removable cartridge or the base instrument may be used to detect the designated reactions.

A device for processing a sample comprises a blister defined by first and second walls. The first wall is flexible allowing the blister to be divided into one or more sealed regions by an external pressure applied to a portion of the first wall. The external pressure is applied in the form of a 2-dimensional shape to form a sealed region having that shape.

There is provided a sample processing cartridge comprising a. a sample entry location; b. a closed sample processing chamber; c. a sample analysis location comprising a sample analysis well; d. a first channel fluidly connecting the sample entry location and the sample processing chamber; e. a second channel connecting the sample analysis location and the sample processing chamber, the second channel comprising a closed or closable second channel valve; wherein the sample processing chamber comprises a second channel port providing fluid connection between the second channel and the sample processing chamber, the second channel port being positioned in a sample accumulating region of the sample processing chamber. There is also provided a sample processing system comprising the cartridge, and methods of use of the cartridge and processing system in a sample processing assay.

Examples of the disclosure relate to an apparatus for analysing fluid samples. The apparatus is sized and shaped so that it can fit into an input port of an electronic device. The input port could be an existing port of the electronic device such as an input port for a memory card or a charger. The electronic device can be configured with a heat transfer means so that, when the apparatus is inserted into the electronic device, heat from the electronic device can be used to control the temperature of a fluid sample within the apparatus. This can enable the reaction conditions within the apparatus to be controlled.

A device for precise dispensing of liquids utilizing pressure-operated valves to control fluid travel. Use of a flexible bulb within a fluid vessel provides manual actuation of the valves through application of pressure to the exterior of the fluid vessel.

Embodiments of a platelet testing system include an analyzer console device and a blood testing cartridge configured to releasably install into the console device. The cartridge device is configured with one or more measuring chambers and one or more mixing chambers that are fluidically connected within the cartridge device that enable the mixing of saline and a blood sample to a desired dilution. Additionally, the cartridge device is further configured with a cartridge slider that provides a reagent bead to the saline and blood mixture at a desired time. As such, one or more platelet activation assays can be conducted by measuring, through cartridge electrodes of the cartridge device, the detectable changes in platelet activity within the blood and saline mixture.

Disclosed are cartridge components, cartridges, systems, and methods for isolating analytes from biological samples. In various aspects, the cartridge components, cartridges, systems, and methods may allow for a rapid procedure that requires a minimal amount of material from complex fluids.

A liquid handling device includes a common channel, a plurality of wells, a magnetic beads chamber and a plurality of valves. The plurality of valves are rotary membrane valves disposed on the circumference of a first circle. The magnetic beads chamber is disposed on a circumference of the second circle concentric with the first circle.

The present invention relates to the field of biomedical technology and discloses a cartridge and a testing device. The cartridge comprises a sample lysis compartment, a first sample mixing compartment and a first PCR compartment; a first valve is disposed between the sample lysis compartment and the first sample mixing compartment, the first valve controls the flowing or blocking of the sample between the sample lysis compartment and the first sample mixing compartment; a fourth valve is disposed between the first PCR compartment and the first sample mixing compartment, the fourth valve controls the flow or blocking of the sample between the first sample mixing compartment and the first PCR compartment; a first reagent is provided in the first sample mixing compartment. In the compartment, nucleic acids in the sample mix with the first reagent and is then sent to the first PCR compartment for amplification.

The present invention aims to provide a fluid handling device which can be manufactured more conveniently, can easily open and close a channel, and can be miniaturized. The fluid handling device of the present invention includes: a first channel; a second channel; and a valve disposed between the first channel and the second channel, in which the valve includes: a groove-shaped valve seat disposed in a board, and a flat plate-shaped flexible layer covering the groove-shaped valve seat, and the valve communicates between the first channel and the second channel when the flat plate-shaped flexible layer and a bottom of the groove-shaped valve seat are spaced apart from each other, and blocks communication between the first channel and the second channel when the flat plate-shaped flexible layer and an inner wall of the groove-shaped valve seat are in contact with each other.