Metered dispensing of a microfluidic amount of fluid from a reservoir comprises a pressure device which applies a discharge pressure for fluid ejection via a discharge line through a valve arrangement. The valve device has a first valve with a minimum closing time and a second valve with a minimum opening time. A control device provides control signals for operation for metered dispensing of the amount of fluid as follows: a shortened minimum opening time for freeing the discharge line for the fluid flow, which time is shorter than the minimum opening time of the second valve; and a shortened minimum closing time for closing the discharge line for the fluid flow, which time is shorter than the minimum closing time of the first valve. Furthermore, a hand-held device for locally piercing human or animal skin is disclosed.

The present disclosure provides devices, systems, methods for processing and/or analyzing a biological sample. An analytic device for processing and/or analyzing a biological sample may comprise a moving carriage. The analytic device may be portable. The analytic device may receive instructions for performing an assay from a mobile electronic device external to a housing of the analytic device.

A microfluidic valve, includes arranging a substrate of a mechanically inert material to one or more physicochemical properties over time, configuring a structural portion of the valve; additive layer manufacturing to print, a succession of one or more filaments of a material with mechanical response to one or more of said physicochemical properties over time, preferably LCP, configuring a functional portion of the valve; and arranging the succession of filaments on the substrate, configuring a fluid flow rate through the valve using the application of an anti-adhesion treatment on one or more interfaces of said filaments and the substrate.

The invention relates to a microfluidic device comprising at least one element (1) of magnetic shape memory (MSM) material for handling of a fluid flow, the MSM element (1) being controlled by a magnetic field. The device comprises elastic material (2) between the handled fluid and the MSM element (1), and that the magnetic field is arranged to form a local shrinkage to the MSM element (1) which together with the elastic material (2) form a shrinkage cavity (3) in a location where the magnetic field is applied to the MSM element. Preferably, the microfluidic device is connected to a lab-on-a-chip, and it can act as one of the followings: a pump, vacuum pump, compressor, refrigerator, valve, manifold, dozer, mixer.

Metered dispensing of a microfluidic amount of fluid from a reservoir comprises a pressure device which applies a discharge pressure for fluid ejection via a discharge line through a valve arrangement. The valve device has a first valve with a minimum closing time and a second valve with a minimum opening time. A control device provides control signals for operation for metered dispensing of the amount of fluid as follows: a shortened minimum opening time for freeing the discharge line for the fluid flow, which time is shorter than the minimum opening time of the second valve; and a shortened minimum closing time for closing the discharge line for the fluid flow, which time is shorter than the minimum closing time of the first valve. Furthermore, a hand-held device for locally piercing human or animal skin is disclosed.

A microfluidic device, including a controllable shape-changing micropillar where a shape of the shape-changing micropillar is changed by a fluid.

Provided herein are methods and devices for controlled metering of a volume of fluid into a bioreactor chamber by use of a thermally-activated actuator that provides simultaneous temperature control and fluidic valve capability. The device may be an elastomeric valve assembly comprising: a thermally-activated actuator, a microfluidic cartridge and an elastomeric membrane operably connected to the thermally-activated actuator. Upon thermal activation of the thermally-activated actuator the elastomeric contact surface is forced into a lumen of the conduit of the microfluidic cartridge to fluidically seal the conduit, while the thermally-activated actuator is in thermal contact with a bioreactor chamber.

The present disclosure provides devices, systems, methods and kits for processing a sample. In some cases, a sample is processed in preparation for an assay (e.g., polymerase chain reaction and immunofluorescence-based target detection) by an analytic device. In some cases, the processing is automated. In some cases, the processing is substantially automated. The systems provided herein can comprise a cartridge (e.g., one-time use) and a dock (e.g., re-useable) for receiving the cartridge. In some cases, the devices and systems provided herein are portable.

The present invention provides an improved method and device for preparing, extracting, separating and/or purifying a biomolecule, for example, nucleic acid from a biological sample. The device comprises a heat-deformable material, such that an inner chamber adopts a second configuration having a chamber volume less than the chamber volume of a first configuration, thereby expelling at least a part of a processed sample through a second opening from the device, and thereby recovering the biomolecule-containing composition.

The invention relates to a microfluidic device comprising at least one element (1) of magnetic shape memory (MSM) material for handling of a fluid flow, the MSM element (1) being controlled by a magnetic field. The device comprises elastic material (2) between the handled fluid and the MSM element (1), and that the magnetic field is arranged to form a local shrinkage to the MSM element (1) which together with the elastic material (2) form a shrinkage cavity (3) in a location where the magnetic field is applied to the MSM element. Preferably, the microfluidic device is connected to a lab-on-a-chip, and it can act as one of the followings: a pump, vacuum pump, compressor, refrigerator, valve, manifold, dozer, mixer.