The invention is a cap for a pathogen sample tube, the tube having an open end and the cap being configured to secure the open end of the tube to prevent spillage of any sample stored in the tube. The cap includes a first pierceable protective film section configured to enable an automated pipette or other sample withdrawal system to pierce the protective film section and to aspirate at least some of the sample. The cap also includes a second pierceable protective film section lying underneath the first pierceable protective film section; the film sections are separated by an air gap, that is approximately 2 mm in depth. The film sections are made from a thin aluminium foil that is approximately 25 microns thick, with a thin lacquer coating on its upper side and a co-extrusion coating, such as a polymer coating, on the lower side.

A blood-viscosity measurement blood collection tube includes a bottomed tube provided with an opening at one end in a length direction and a bottom at the other in the length direction, and a sealing plug. The sealing plug includes a sealing part fitted in the opening of the bottomed tube in a hermetically sealed state, a cap part, and a thin connecting part. The sealing part includes a vertically penetrated insertion hole. The sealing part of the sealing plug is fitted in the opening of the bottomed tube, and an inner space of the bottomed tube is in a negative pressure state. The cap part is configured to be removed from the sealing plug by breaking the connecting part with an external force applied to the cap part, and the insertion hole is exposed at an upper surface of the sealing part when the cap part has been removed.

In a method for metering minimum liquid quantities, a vessel closed in a pressure-tight manner is acted on by compressed air to transport liquid from the vessel through a transfer tubing to a metering valve.

Provided is a cell isolation instrument capable of smoothly performing a plurality of steps associated with isolation of cells, including gripping of a biological tissue, transferring of the biological tissue, and isolating of the biological tissue. A container has an opening. A sealing member seals the opening. A pair of pinching parts is connected to the sealing member, and the pair of pinching parts opens or closes by being pressed.

The disclosure relates to devices, solutions and methods for collecting and processing samples of bodily fluids containing cells (as well as embodiments for the collection, and processing and/or analysis of other fluids including toxic and/or hazardous substances/fluids). In addition, the disclosure relates generally to function genomic studies and to the isolation and preservation of cells from saliva and other bodily fluids (e.g., urine), for cellular analysis. With respect to devices for collection of bodily fluids, some embodiments include two mating bodies, a cap and a tube (for example), where, in some embodiments, the cap includes a closed interior space for holding a sample preservative solution and mates with the tube to constitute the (closed) sample collection device. Upon mating, the preservation solution flows into the closed interior space to preserve cells in the bodily fluid. The tube is configured to receive a donor sample of bodily fluid (e.g., saliva, urine), which can then be subjected to processing to extract a plurality of cells. The plurality of cells can be further processed to isolate one and/or another cell type therefrom. The plurality of cells, as well as the isolated cell type(s), can be analyzed for functional genomic and epigenetic studies, as well as biomarker discovery.

The disclosure relates to devices, solutions and methods for collecting and processing samples of bodily fluids containing cells (as well as embodiments for the collection, and processing and/or analysis of other fluids including toxic and/or hazardous substances/fluids). In addition, the disclosure relates generally to function genomic studies and to the isolation and preservation of cells from saliva and other bodily fluids (e.g., urine), for cellular analysis. With respect to devices for collection of bodily fluids, some embodiments include two mating bodies, a cap and a tube (for example), where, in some embodiments, the cap includes a closed interior space for holding a sample preservative solution and mates with the tube to constitute the (closed) sample collection device. Upon mating, the preservation solution flows into the closed interior space to preserve cells in the bodily fluid. The tube is configured to receive a donor sample of bodily fluid (e.g., saliva, urine), which can then be subjected to processing to extract a plurality of cells. The plurality of cells can be further processed to isolate one and/or another cell type therefrom. The plurality of cells, as well as the isolated cell type(s), can be analyzed for functional genomic and epigenetic studies, as well as biomarker discovery.

A nucleic acid amplification method includes a step of heating a first region of a container housing a droplet containing a target nucleic acid and a sample necessary for amplification of the target nucleic acid to a denaturation temperature of the target nucleic acid and heating a second region different from the first region to a synthesis temperature of the target nucleic acid, and an amplification step of repeating a cycle through a denaturation stage at which the droplet housed in the container is moved to and retained in the first region and a synthesis stage at which the droplet is moved to and retained in the second region at a plurality of times. At the amplification step, periods of part of cycles of the plurality of cycles are made shorter than periods of the other cycles.

A moisture-tight, re-sealable container is disclosed having a lid and body. The lid and body have a non-round seal that is substantially moisture tight when the lid is seated on the body, admitting less than 1000 micrograms per day of water to a package. A reinforcement stiffens or reinforces at least a portion of the seal against inward deflection along an axis defined by the minor diameter when the lid is seated on the body. Optionally the reinforcement is at least one spline subdividing the reservoir. A method of making dispensers for objects of varying length to customize particular dispensers to dispense such objects of a particular length is also disclosed.

A rubber stopper for a medicine container has a rubber stopper body and a coating layer directly applied to a surface exposed in the medicine container. The coating layer is more flexible than a forming material of the rubber stopper body. The said coating layer comprises a composition containing a silicone-based resin which comprises a condensate of a reactive silicone having a terminal silanol group, and wherein the condensate contains a siloxane bond derived from the silanol group.

A secure specimen sample bottle includes a base container for receiving a specimen. The base container has a plurality of locking protrusions formed along an inner surface of the base receptacle. A bottle includes a lock ring that has an upright spire structure that has a closed top end and the opposing open bottom end including a plurality of flexible fins that are configured to interlockingly mate with the locking protrusions so as to prevent removal of the lock ring relative to the base container upon engagement of the flexible fins to the locking protrusions. A removable cap is coupled to the lock ring.