The present disclosure provides antibody cytokine engrafted proteins that bind to and stimulate intracellular signaling through a high affinity interleukin receptor. The antibody cytokine engrafted proteins find use in enhancing anti-inflammatory cell responses, and reducing pro-inflammatory effects in the treatment, amelioration and prevention of immune related disorders such as Type 1 Diabetes.

A roller mill includes a shell provided with a feed port and a discharge port; a main shaft inserted in the shell and rotatable in the shell; a drive device drivingly connected to the main shaft a holder mounted on the main shaft two or more than two grinding rollers, each of the grinding rollers mounted on the holder and rotatable around its own axis; and a grinding disk fixedly mounted in the shell at a position opposite to the multiple grinding rollers. The roller mill further includes an axial position adjustment device connected to the main shaft and configured to drive the main shaft to move axially to adjust a position of the main shaft.

A roller mill includes a shell provided with a feed port and a discharge port; a main shaft inserted in the shell and rotatable in the shell; a drive device drivingly connected to the main shaft a holder mounted on the main shaft two or more than two grinding rollers, each of the grinding rollers mounted on the holder and rotatable around its own axis; and a grinding disk fixedly mounted in the shell at a position opposite to the multiple grinding rollers. The roller mill further includes an axial position adjustment device connected to the main shaft and configured to drive the main shaft to move axially to adjust a position of the main shaft.

Automated grinder systems include several different automatic functions including liquid and substrate soaking, mixing, grinding, fermenting, and cleaning. Example grinders include storages for soaking and draining a substrate for grinding, a water or other fluid reservoir connected to provide soaking material, and a grinder connected to the storage to receive and grind the substrate. A resting unit may receive the ground batter and potentially ferment the same by controlling its temperature, humidity, pH, etc. Jets may be connected to a water reservoir and direct liquid water into the grinder, potentially with soap, to cleanse the same.

The invention relates to a vertical roller mill and a method for operating a vertical roller mill, wherein the grinding assemblies thereof, consisting of a grinding table and at least one grinding roller, interact such that material to be ground is comminuted in the grinding bed between the grinding table and the at least one grinding roller, wherein at least one grinding assembly is driven and at least one grinding assembly is pulled, and the pulled grinding assembly is braked in order to increase the flow of energy through the grinding bed between the grinding table and the at least one grinding roller.

The invention relates to a vertical roller mill and a method for operating a vertical roller mill, wherein the grinding assemblies thereof, consisting of a grinding table and at least one grinding roller, interact such that material to be ground is comminuted in the grinding bed between the grinding table and the at least one grinding roller, wherein at least one grinding assembly is driven and at least one grinding assembly is pulled, and the pulled grinding assembly is braked in order to increase the flow of energy through the grinding bed between the grinding table and the at least one grinding roller.