An agitator ball mill includes a grinding chamber, a rotatably mounted agitator shaft, which protrudes into the grinding chamber and on which agitator elements, in the form of paddle wheels, are arranged spaced apart from one another axially, and an inlet for supplying material to be ground and grinding bodies and an outlet for removal of the ground material. The agitator elements are constructed in such a way that, during operation, they convey a mixture consisting of material to be ground or dispersed and grinding bodies through their interior outwards away from the agitator shaft. In the grinding chamber there are arranged return conveyor elements which are joined to the agitator shaft for conjoint rotation therewith and which convey the mixture laterally alongside and/or between the agitator elements inwards towards the agitator shaft.

An agitator mill including a grinding chamber containing grinding bodies and an agitator shaft, which revolves therein about a horizontal agitator shaft axis, which supports several grinding members, which are connected to it in a rotationally fixed manner and which are spaced apart from one another in the direction of the horizontal axis, preferably in the shape of grinding disks, which move the grinding bodies, whereby, on the outlet side, the agitator shaft has a basket, which is preferably studded with grinding members on its outer circumference and which overlaps the split tube-supporting outlet, whereby a separation chamber is formed between the inner surface of the basket and the split tube-supporting outlet, whereby the basket has slits for returning grinding bodies from the separation chamber into the grinding chamber, which slits lead into the free front surface of the basket, which faces away from the grinding chamber.

An agitator shaft (1) for a grinding mill, including: an axle (2) intended to be driven in rotation, a succession of flat agitator elements (3) and tubular spacers (4) mounted in alternation on the axle and in a stack along the axle (2), end stops (5, 6), secured to the axle, that keep the stack of agitator elements and spacers under compression, characterized in that the tubular spacers (4) have orifices allowing the free circulation of material and fluids from the outside of the agitator shaft to the inside, and vice versa.

Pharmaceutical compositions comprising at least one wetting agent, at least one excipient, at least one buffer, at least one pH modifier, and at least one active pharmaceutical ingredient. Methods for preparing the pharmaceutical compositions in which the active pharmaceutical ingredient is milled to provide a particle size distribution using a one-step milling process.

An agitator shaft (1) for a grinding mill, including: an axle (2) intended to be driven in rotation, a succession of flat agitator elements (3) and tubular spacers (4) mounted in alternation on the axle and in a stack along the axle (2), end stops (5, 6), secured to the axle, that keep the stack of agitator elements and spacers under compression, characterized in that the tubular spacers (4) have orifices allowing the free circulation of material and fluids from the outside of the agitator shaft to the inside, and vice versa.

An improvement in an apparatus and a method produces a particle dispersion by processing a particle-carrying feedstock passed from a supply vessel through a bed of media contained within a containment wall having an inlet end and a longitudinally opposite terminal end. An auxiliary chamber surrounds the containment wall so that the feedstock is passed from the bed of media, through the containment wall and into the auxiliary chamber while the media is contained within the bed of media. An external pumping mechanism established a pressure differential that draws the feedstock into the containment wall and through the bed of media, then through the containment wall into the auxiliary chamber, and then out of the auxiliary chamber at a location juxtaposed with the containment wall between the inlet end and the terminal end, while maintaining a negative pressure within the supply vessel and within the auxiliary chamber during processing of the feedstock.

An agitator ball mill comprises a grinding chamber (1), a rotatably mounted agitator shaft (5), which protrudes into the grinding chamber (1) and on which agitator elements (10, 20, 30), in the form of paddle wheels, are arranged spaced apart from one another axially, and an inlet (6) for supplying material to be ground and grinding bodies and an outlet (7) for removal of the ground material. The agitator elements (10, 20, 30) are constructed in such a way that, during operation, they convey a mixture consisting of material to be ground or dispersed and grinding bodies through their interior outwards away from the agitator shaft (5). In the grinding chamber (1) there are arranged return conveyor elements (17, 27, 37; 47; 57) which are joined to the agitator shaft (5) for conjoint rotation therewith and which convey the mixture laterally alongside and/or between the agitator elements (10, 20, 30) inwards towards the agitator shaft (5).

An adapter for enabling grinding of one or more materials using a dual-asymmetric centrifugal mixer, the adapter to be fitted into a container of the dual-asymmetric centrifugal mixer; it has a shell defining an inner compartment; and openings on the shell, wherein the inner compartment is configured to receive the grinding media for grinding the one or more materials, and the openings enable the one or more materials to enter and/or leave the inner compartment for grinding by the grinding media when subject to the centrifugal force applied by the centrifugal mixer while maintaining the grinding media in the inner compartment; method of use thereof.