B03C1/032

PREPARING ANTIGEN-SPECIFIC T CELLS USING A SELF-ENCLOSED PROCESSING SYSTEM THAT CONTAINS BOTH A CENTRIFUGE AND A MAGNETIC SEPARATION COLUMN

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

Electromagnetic fluid filter using magnetostrictive sensors

In at least one illustrative embodiment, an electromagnetic filter may include a transfer pipe and multiple electromagnetic filter elements positioned in an interior volume of the pipe. Each electromagnetic filter element includes a support comb, a solenoid coupled to the support comb, and multiple magnetic members arranged in a planar array positioned within an opening of the support comb. Each magnetic member may rotate about an end that is coupled to the support comb. The magnetic members may be magnetostrictive sensors and may include a biorecognition element to bind with a target microorganism. A method for fluid filtration includes coupling the electromagnetic filter between a fluid source and a fluid destination, energizing the solenoids of each electromagnetic filter elements, and flowing a fluid media through the transfer pipe of the electromagnetic filter. The fluid media may be liquid food such as fruit juice. Other embodiments are described and claimed.

Electromagnetic fluid filter using magnetostrictive sensors

In at least one illustrative embodiment, an electromagnetic filter may include a transfer pipe and multiple electromagnetic filter elements positioned in an interior volume of the pipe. Each electromagnetic filter element includes a support comb, a solenoid coupled to the support comb, and multiple magnetic members arranged in a planar array positioned within an opening of the support comb. Each magnetic member may rotate about an end that is coupled to the support comb. The magnetic members may be magnetostrictive sensors and may include a biorecognition element to bind with a target microorganism. A method for fluid filtration includes coupling the electromagnetic filter between a fluid source and a fluid destination, energizing the solenoids of each electromagnetic filter elements, and flowing a fluid media through the transfer pipe of the electromagnetic filter. The fluid media may be liquid food such as fruit juice. Other embodiments are described and claimed.

Magnetic Ljungstrom filter

A heat exchange apparatus for removing magnetic particulates from a gas stream, including a rotating element basket having a regenerative heat exchanger and at least one magnetic element. A method of removing magnetic particulates from a gas stream, including heating the regenerative heat exchanger during a first portion of a cycle as a segment of the rotating element basket passes through a first zone wherein contact is made with a flue gas thereby accumulating any magnetic particulates as they are attached to the magnetic element. Then cleaning a portion of the magnetic element during a second portion of the cycle. And cooling the regenerative heat exchanger and simultaneously heating an inlet air stream during a third portion of the cycle as the segment of the rotating element basket passes through a third zone wherein fluidic contact is made with the air inlet stream.

Magnetic Ljungstrom filter

A heat exchange apparatus for removing magnetic particulates from a gas stream, including a rotating element basket having a regenerative heat exchanger and at least one magnetic element. A method of removing magnetic particulates from a gas stream, including heating the regenerative heat exchanger during a first portion of a cycle as a segment of the rotating element basket passes through a first zone wherein contact is made with a flue gas thereby accumulating any magnetic particulates as they are attached to the magnetic element. Then cleaning a portion of the magnetic element during a second portion of the cycle. And cooling the regenerative heat exchanger and simultaneously heating an inlet air stream during a third portion of the cycle as the segment of the rotating element basket passes through a third zone wherein fluidic contact is made with the air inlet stream.

DEVICES AND DISPOSABLES FOR PATIENT-SPECIFIC CELL THERAPY MANUFACTURING

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

DEVICES AND DISPOSABLES FOR PATIENT-SPECIFIC CELL THERAPY MANUFACTURING

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

Equipment and procedure for culturing, separating, and genetically modifying donor cells for reinfusion into a patient

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

Equipment and procedure for culturing, separating, and genetically modifying donor cells for reinfusion into a patient

The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

MAGNETIC LJUNGSTROM FILTER
20220040705 · 2022-02-10 ·

A heat exchange apparatus for removing magnetic particulates from a gas stream, including a rotating element basket having a regenerative heat exchanger and at least one magnetic element. A method of removing magnetic particulates from a gas stream, including heating the regenerative heat exchanger during a first portion of a cycle as a segment of the rotating element basket passes through a first zone wherein contact is made with a flue gas thereby accumulating any magnetic particulates as they are attached to the magnetic element. Then cleaning a portion of the magnetic element during a second portion of the cycle. And cooling the regenerative heat exchanger and simultaneously heating an inlet air stream during a third portion of the cycle as the segment of the rotating element basket passes through a third zone wherein fluidic contact is made with the air inlet stream.