A method for filtering magnetic particles includes spinning a filter including a plurality of pores within a substrate. The method further includes applying, subsequent to spinning the filter, an external magnetic field to the filter. The method includes disposing a solution including a first particle and a second particle onto the filter. The first particle includes a magnetic particle of interest. The method further includes separating the first particle from the second particle by capturing the first particle within a pore of the plurality of pores within the substrate.

A magnetic matrix for magnetic separation of particles in a material feed includes a plurality of grooved plates having first and second sides that both have an alternating series of teeth and grooves therealong, each grooved plate having an offset alignment in which teeth and grooves on a first side of a plate are laterally offset from teeth and grooves on a second side of the same plate. Also provided are methods of using magnetic matrices to separate magnetic ores, with the methods characterized by a negative correlation in which magnetic matrices constructed with grooved plates having larger pitches are used for the separation of ultrafine particles.

A fluid preparation device can include a fluid-receiving vessel and a fluid loader with multiple fluid chambers including a first fluid chamber and a second fluid chamber. The multiple fluid chambers can partially be defined by actuator seals that are positioned on an actuator. The actuator can be moveable among a plurality of positions and the actuator seals can be positioned on the actuator to fluidically separate the first fluid chamber from the second fluid chamber when the actuator is in a closed position from the plurality of positions, allow fluidic communication between the second fluid chamber and the fluid-receiving vessel when the actuator is in a first open position from the plurality of positions, and allow fluidic communication between the first fluid chamber and the second fluid chamber when the actuator is in a second open position from the plurality of positions.

A biological component separator can include a vertically layered fluid column with a plurality of fluids positioned in fluid layers and a density-differential interface along which two fluids from the plurality of fluids are positioned. The biological component separator can also include a magnetic field generator positioned about the vertically layered fluid column and having multiple magnetic field profiles appliable across the vertically layered fluid column. The multiple magnetic field profiles can include a particle aggregating profile to concentrate magnetizing particles when present in the vertically layered fluid column and a particle sweeping profile to re-suspend and sweep the magnetizing particles when present across the vertically layered fluid column.

A biological component separator can include a vertically layered fluid column with a plurality of fluids positioned in fluid layers and a density-differential interface along which two fluids from the plurality of fluids are positioned. The biological component separator can also include a magnetic field generator positioned about the vertically layered fluid column and having multiple magnetic field profiles appliable across the vertically layered fluid column. The multiple magnetic field profiles can include a particle aggregating profile to concentrate magnetizing particles when present in the vertically layered fluid column and a particle sweeping profile to re-suspend and sweep the magnetizing particles when present across the vertically layered fluid column.

A vertically layered fluid column can include a plurality of fluids positioned in fluid layers, a density-differential interface along which two fluids from the plurality of fluids are positioned, and a capillary force-supported interface along which two fluids from the plurality of the fluids are positioned.

The present invention is directed to methods for using particles (e.g, microparticulate, nanoparticulate; magnetic, non-magnetic) comprising surfaces comprising capture moieties as described herein, to remove an interference as described herein, or enrich biomarkers, prior to a diagnostic test.

The present invention is directed to methods for using particles (e.g, microparticulate, nanoparticulate; magnetic, non-magnetic) comprising surfaces comprising capture moieties as described herein, to remove an interference as described herein, or enrich biomarkers, prior to a diagnostic test.

A system for separating particles or cells by magnetic ratcheting has a vector of spaced apart magnetic bars on a substrate. The system can be used to separate and concentrate magnetic objects based on iron oxide content. For cells, different phenotypes may be separated based on surface expression of proteins or molecules that are bound to magnetic beads. A magnetic field generator generates a cycling magnetic field that acts to separate magnetic particles or cells from non-magnetic particles or cells in a solution.

A system for separating particles or cells by magnetic ratcheting has a vector of spaced apart magnetic bars on a substrate. The system can be used to separate and concentrate magnetic objects based on iron oxide content. For cells, different phenotypes may be separated based on surface expression of proteins or molecules that are bound to magnetic beads. A magnetic field generator generates a cycling magnetic field that acts to separate magnetic particles or cells from non-magnetic particles or cells in a solution.