A magnetic filter according to one embodiment of the present disclosure includes a housing through which fluid or powder containing metal particles passes; magnets arranged inside the housing; and a rotation unit that rotates the magnets so as to revolve around the rotation center, wherein the magnets include first magnets and second magnets located farther from the rotation center than the first magnets, and wherein any one of the second magnets forms an equilateral triangle arrangement with two first magnets adjacent to any one of the second magnets.

A magnetic filter according to one embodiment of the present disclosure includes a housing through which fluid or powder containing metal particles passes; magnets arranged inside the housing; and a rotation unit that rotates the magnets so as to revolve around the rotation center, wherein the magnets include first magnets and second magnets located farther from the rotation center than the first magnets, and wherein any one of the second magnets forms an equilateral triangle arrangement with two first magnets adjacent to any one of the second magnets.

A magnetic pole for use in a magnetic separator comprises a body having a central core and two cantilevered pole arms, each pole arm extending at a perpendicular angle relative to the central core and having a faceplate at and end thereof, wherein at least one cantilevered pole arm and corresponding faceplate thereof are adapted for selective removal and re-attachment of the faceplate with the cantilevered pole arm.

A method for filtering magnetic particles includes spinning a filter including a plurality of pores within a substrate. The method further includes applying, subsequent to spinning the filter, an external magnetic field to the filter. The method includes disposing a solution including a first particle and a second particle onto the filter. The first particle includes a magnetic particle of interest. The method further includes separating the first particle from the second particle by capturing the first particle within a pore of the plurality of pores within the substrate.

A system is provided for the quantitative magnetic separation of magnetic objects (e.g., particles or cells). The system uses magnetic ratcheting over arrays of ferromagnetic elements having gradient spacing manifested in various pitch zones that are encountered by the magnetic objects as they traverse the array. The system can be used to separate and concentrate magnetic objects based on iron oxide content. For cells, different phenotypes may be separated based, for example, on surface expression of proteins or molecules that are bound to magnetic particles. The system includes a substrate or chip having the array of ferromagnetic elements with increasing lateral pitch and an externally driven magnet device that generates a cycling magnetic field. Magnetic objects with higher IOC separate and equilibrate along the array at larger pitches. The system can be used for the differential sorting of particles and cells of interest.

A system is provided for the quantitative magnetic separation of magnetic objects (e.g., particles or cells). The system uses magnetic ratcheting over arrays of ferromagnetic elements having gradient spacing manifested in various pitch zones that are encountered by the magnetic objects as they traverse the array. The system can be used to separate and concentrate magnetic objects based on iron oxide content. For cells, different phenotypes may be separated based, for example, on surface expression of proteins or molecules that are bound to magnetic particles. The system includes a substrate or chip having the array of ferromagnetic elements with increasing lateral pitch and an externally driven magnet device that generates a cycling magnetic field. Magnetic objects with higher IOC separate and equilibrate along the array at larger pitches. The system can be used for the differential sorting of particles and cells of interest.

The present invention is directed towards an apparatus and methods for a precise, fast and easy to use manipulation of beads. This method is particularly useful to carry out separation between the beads and the remaining supernants present in the fluid, maximizing the collection and purification efficiencies in tips for liquid handling.

A magnetic drum separator comprises a drum rotatable about an axis, the drum comprising an internal chamber and an opening at an end of the drum providing access into the internal chamber. The magnetic drum separator also comprises an inlet for supplying a liquid or granular substance into the internal chamber through the opening, a magnet outside of the drum for attracting magnetic material in the liquid or granular substance towards an internal sidewall of the internal chamber, a collection device for recovering magnetic material attracted to the internal sidewall and an annular seal member attached to the end of the drum that rotates with the drum in use. A baffle that bears against the annular seal member partially seals the opening. A plurality of cavities formed in the annular seal member receive fluid leaking into a boundary between the annular seal member and the baffle.

A magnetic drum separator comprises a drum rotatable about an axis, the drum comprising an internal chamber and an opening at an end of the drum providing access into the internal chamber. The magnetic drum separator also comprises an inlet for supplying a liquid or granular substance into the internal chamber through the opening, a magnet outside of the drum for attracting magnetic material in the liquid or granular substance towards an internal sidewall of the internal chamber, a collection device for recovering magnetic material attracted to the internal sidewall and an annular seal member attached to the end of the drum that rotates with the drum in use. A baffle that bears against the annular seal member partially seals the opening. A plurality of cavities formed in the annular seal member receive fluid leaking into a boundary between the annular seal member and the baffle.

A method for filtering magnetic particles includes spinning a filter including a plurality of pores within a substrate. The method further includes applying, subsequent to spinning the filter, an external magnetic field to the filter. The method includes disposing a solution including a first particle and a second particle onto the filter. The first particle includes a magnetic particle of interest. The method further includes separating the first particle from the second particle by capturing the first particle within a pore of the plurality of pores within the substrate.