The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

A fluid separation device includes a centrifugal separator configured to receive a centrifugal separation chamber of a disposable fluid flow circuit, a pump system configured to convey a fluid into the centrifugal separation chamber and to remove a separated fluid component from the centrifugal separation chamber via an outlet, a color-based interface monitoring system configured to determine an interface position between separated fluid components continuously flowing through the centrifugal separation chamber based on dominant wavelength measurements of layers of separated fluid components during a centrifugal separation procedure, and a controller configured to measure the dominant wavelengths of the layers, calculate a duration as a color time for each measured dominant wavelength, set target color times, calculate error signals and calculate control signals to adjust the pump system to control the flow rate and interface position.

According to an embodiment, a centrifugal separation apparatus includes, a centrifugal separator comprising a retainer and a rotating member for rotation of the retainer, the retainer adapted to retain a workpiece, an imaging unit configured to acquire a detection image of an installation position at which the retainer is placed, a transfer mechanism configured to move the workpiece into the centrifugal separator, and a sensor processing unit configured to detect, based on the detection image acquired after an installation process of placing the workpiece into the retainer and before a rotation process of rotating the rotating member, a state of the workpiece subjected to the installation process.

A centrifuge is configured to provide integrated separation of blood components such that the separated products remain spinning within the centrifuge during the separation process. The centrifuge includes a disposable configured to separate the blood components such that the separated products remain within the disposable while the centrifuge is spinning; an integrated sensor system capable of determining a composition of the separated products within the disposable while the centrifuge is spinning; a chamber having a non-circular section that is configured to be deliberately un-balanced when the centrifuge chamber is empty; and the disposable includes valves that rotate with the centrifuge chamber.

A fluid separation device includes a centrifuge in which a fluid is separated into at least two components, with an interface therebetween. At least a portion of one of the separated fluid components is removed from the centrifuge and flows through a vessel. Light is reflected off of the separated fluid component in the vessel and received and analyzed to determine its main wavelength. If the main wavelength is higher than a maximum value, a target location of the interface is changed. If the main wavelength is less than the maximum value, then the location of the interface is compared to the target location. When the interface is sufficiently close to the target location, the optical density of the separated fluid component in the vessel is compared to a minimum value. If the optical density is less than the minimum value, the target location of the interface is changed.

The present disclosure provides a method of operating a separator (1,1a, 1b) for separating particles from a particle-laden airflow. The method comprises receiving, in the controller (18), a separation unit status signal from the separation unit status sensor (16a, 16b, 16c, 16d), deriving, in the controller (18), separator status data based on the separation unit status signal, communicating, via the communication device (19), the separator status data to the external unit (1a, 1b, 26), receiving, via the communication device (19), incoming control data from the external unit (1a, 1b, 26), determining, in the controller (18), based on the separator status data and based on the incoming control data, whether to initiate separating unit maintenance, and selectively initiating separating unit maintenance based on said determination. The disclosure also provides a separator for implementing the method and a system comprising two or more such separators.

A rotor comprises a support intended to be mounted rotatable around a rotation axis in a centrifuge enclosure. The support having at least one housing for receiving the sample. At least one electrically powered sensor held by the support, configured to measure a property of the sample. A contactless power receiver, configured to receive electrical power without contact from a contactless power transmitter, the contactless power receiver being carried by the support and being jointly rotatable with the support, the contactless power receiver being electrically connected to the at least one sensor to electrically power the at least one sensor during a rotation of the support.

A continuous flow centrifuge bowl includes a rotatable outer body, and a top and bottom core that are rotatable with the outer body. The bottom core has a wall extending proximally from a bottom wall. The proximally extending wall is radially outward from at least a portion of the top core and, together with the top core, defines a primary separation region in which initial separation of the whole blood occurs. The bowl may also have a secondary separation region located between the top core and the outer body, and a rotary seal that couples an inlet port and two outlet ports to the outer body. The inlet port may be connected to an inlet tube that extends distally into a whole blood introduction region. Additionally, one of the outlet ports may be connected to an extraction tube that extends into a region below the bottom core.

Systems and methods are provided for separating blood into two or more components. A blood separation system includes a blood separation device and a fluid flow circuit configured to be mounted to the blood separation device. The blood separation device includes a centrifugal separator and a spinning membrane separator drive unit incorporated into a common case, which allows for fluid separation by two different methods. Depending on the separation procedure to be carried out, the fluid flow circuit paired with the blood separation device may include only one separation chamber configured to be mounted to the centrifugal separator or spinning membrane separator drive unit or two separation chambers, with one being mounted to the centrifugal separator and the other to the spinning membrane separator drive unit. The system may be used to separate and collect any combination of red blood cells, plasma, and platelets.

Method and Apparatus for predicting the volume of a component separated from a composite fluid by predicting the volume of the composite fluid from sensed pressure and predicting the volume of other separated components from sensed movement of the other components to collection bags.