A method for manufacturing a medical instrument having a lubricating layer (coating layer) that exhibits excellent durability (particularly, sliding durability) is provided. The method for manufacturing a medical instrument is a method for manufacturing a medical instrument that includes a base layer and a lubricating layer carried on at least a portion of the base layer. The method includes applying a solution including a block copolymer having a structural unit derived from a reactive monomer having an epoxy group and a structural unit derived from a hydrophilic monomer, a choline derivative, and a solvent, on the base layer.

The present invention relates to a multi-layer coating film formation method in which the following are performed: a step in which a primer coating film is formed; a step in which a base coating film is formed; a step in which a clear coating film is formed; and a step in which these coating films are caused to harden simultaneously. The method satisfies at least: (A) the quantity of isocyanate at the interface between a coated article and the primer coating film is 1.5 parts by mass or less, relative to 100 parts by mass of resin solids in a primer coating material; or (B) the quantity of isocyanate at the interface between the primer coating film and the base coating film is 3.5 parts by mass or less, relative to 100 parts by mass of resin solids in a base coating material.

The present invention relates to a multi-layer coating film formation method in which the following are performed: a step in which a primer coating film is formed; a step in which a base coating film is formed; a step in which a clear coating film is formed; and a step in which these coating films are caused to harden simultaneously. The method satisfies at least: (A) the quantity of isocyanate at the interface between a coated article and the primer coating film is 1.5 parts by mass or less, relative to 100 parts by mass of resin solids in a primer coating material; or (B) the quantity of isocyanate at the interface between the primer coating film and the base coating film is 3.5 parts by mass or less, relative to 100 parts by mass of resin solids in a base coating material.

A method for plasma coating a compressible structure, includes the steps of: compressing the compressible structure thereby removing air from the compressible structure; and coating the compressed structure according to the following steps: a) ionizing a plasma gas at a temperature of 150? C. or lower, and at about atmospheric pressure, thereby creating a plasma; b) introducing a precursor into said plasma, thereby obtaining a precursor-comprising plasma; c) exposing the compressed structure to said precursor-comprising plasma, thereby forming a coating onto surfaces of the structure.