Even when the filling speed increases, the surface temperature of a molded bottle falls within a constant range, and a sterilizer adequately sterilizes the bottle.

A preform is heated, the heated preform is sealed in a mold, the preform sealed in the mold is blow-molded into a bottle, the surface temperatures of a neck portion, a body portion, and a bottom portion of the molded bottle are measured, and the mold temperatures of a neck portion, a body portion, and a bottom portion of the mold is so adjusted that the measured surface temperature of the bottle falls within a specified temperature range.

Even when the filling speed increases, the surface temperature of a molded bottle falls within a constant range, and a sterilizer adequately sterilizes the bottle. A preform is heated, the heated preform is sealed in a mold, the preform sealed in the mold is blow-molded into a bottle, the surface temperatures of a neck portion, a body portion, and a bottom portion of the molded bottle are measured, and the mold temperatures of a neck portion, a body portion, and a bottom portion of the mold is so adjusted that the measured surface temperature of the bottle falls within a specified temperature range.

Systems and methods for automatic and dynamic temperature adjustment and over-cooling of a rotary Blow-Fill-Seal (BFS) manufacturing device to reduce the fill product temperature such as for filling of BFS vials with cold-temperature vaccines.

Systems and methods for automatic and dynamic temperature adjustment and over-cooling of a rotary Blow-Fill-Seal (BFS) manufacturing device to reduce the fill product temperature such as for filling of BFS vials with cold-temperature vaccines.

Systems and methods for automatic and dynamic temperature adjustment and over-cooling of a rotary Blow-Fill-Seal (BFS) manufacturing device to reduce the fill product temperature such as for filling of BFS vials with cold-temperature vaccines.