The present invention provides a microneedle array, a support member, a method of producing a microneedle array, and a microneedle array unit which enable reduction of a drying time during production and prevention of breakage during drying. Provided are a microneedle array 120 including a sheet portion 41, a plurality of needle-like protrusions 44, and a support member 50 formed of a gripping portion 52 and a beam portion 54 having one end that is connected to the gripping portion 52, in which the sheet portion 41 is an integrally molded body which is integrally molded with the support member 50, in which at least a part of the beam portion 54 is buried under the other surface 43 of the sheet portion 41, opposite to the one surface where the needle-like protrusions 44 are provided, the gripping portion 52 is provided on the other surface 43 of the sheet portion 41, and the beam portion 54 is deformable toward a center of the sheet portion 41. Further, provided are the support member 50, a method of producing the microneedle array 120, and a microneedle array unit 300 including a container 310.

Systems and methods are provided for fabricating microneedle arrays that includes electrospun fibers preferentially disposed within the microneedles of the array. Providing the electrospun fibers preferentially in the microneedles allows for more of a drug or other substance present in the fibers to be deposited into tissue or to provide other benefits. A mold for forming the microneedle arrays includes an insulating surface layer. The insulating surface layer affects the electric field during electrospinning such that electrospun fibers are deposited preferentially within the microneedle cavities of the mold relative to the surface of the mold. A bulk material can then be applied to the mold to form the bulk of the microneedles with electrospun fibers embedded within and a backing layer to which the microneedles are attached.

A method of preparing a structure is provided. The method includes providing an initial structure; casting a first material in one or more void volumes of the initial structure; removing the initial structure from the first material; obtaining a cast structure comprising the first material; coating a second material on the cast structure; casting a third material using the coated cast structure; removing the first material; and obtaining a final structure. In various embodiments, the initial structure can include a first initial structure and a second initial structure and casting a first material in one or more first void volumes of the first initial structure and in one or more second void volumes of the second initial structure. In various embodiments, the method includes assembling the first cast structure and the second cast structure and obtaining an assembled structure comprising the first cast structure and the second cast structure.

A handle in which a sensor layer capable of detecting grip is disposed on a gripping portion that is gripped at a time of steering. The gripping portion includes a core material, a covering layer formed of urethane foam, which is disposed by die-molding so as to cover a periphery of the core material, the sensor layer, and a protective layer covering the sensor layer. The sensor layer is formed of a mold coat agent formed of a urethane-based paint containing a conductive material. The mold coat agent is applied to a die surface of a molding die of the covering layer. At a time of molding the covering layer, the sensor layer formed of the mold coat agent is disposed on a surface side of the covering layer.

A method of forming a ceramic matrix composite component. The ceramic matrix composite component is adapted for use in a gas turbine engine. The method including forming the component using ceramic materials and infiltrating the component with a matrix material.

A microneedle array unit including a microneedle array having a plurality of needle-like protrusions arranged on one surface thereof, a gripping portion provided on a side opposite to the plurality of needle-like protrusions of the microneedle array, and a container configured to accommodate the microneedle array. The container includes an accommodation portion having an opening, a deformable portion disposed on a side opposite to the opening, and a binding portion provided in the accommodation portion of the deformable portion and bound to the gripping portion of the microneedle array. The deformable portion is deformed by receiving an external force in a direction of the opening and presses the microneedle array through the gripping portion, and the microneedle array is pushed out of the accommodation portion by being pressed, and the deformable portion maintains a deformed state and presses the microneedle array.

Interconnects may comprise a sandwich-structured composite comprising a core layer located between two thermosetting polymer layers. The core layer may comprise 80 wt % to 95 wt % conductive metal and a polymer. The conductive metal may comprise silver (Ag). The polymer may comprise polydimethylsiloxane (PDMS). Interconnects may be particularly suited for use in electronic devices, such as a flexible batteries and wearable electronic devices.

A method for manufacturing a cosmetic stick having at least two different colored portions includes inserting a pin into at least one mold cavity of a mold body, filling the mold cavity containing the pin with a first cosmetic material of a first color, and then recovering the excess first cosmetic material from a top surface of the mold body. The pin is removed from the mold cavity leaving a void in the mold cavity, and a guard plate is placed over the top surface of the mold body, the guard plate having a hole over the mold cavity. The void in the mold cavity is filled with a second cosmetic material, the second cosmetic material being a second color that is different than the first color. The excess second cosmetic material is then recovered from a top surface of the guard plate.

A process for manufacturing a rubber patch comprising a radiofrequency transponder, the patch having a first layer and a second layer, the method comprising moulding and vulcanizing a first layer, the exterior surface of which comprises a cavity able to receive a radiofrequency transponder, placing a transponder in the cavity, and then placing and vulcanizing a second layer in order to embed the transponder between the two layers.

A method of producing a transdermal absorption sheet includes: filling needle-like recessed portions of a mold with a drug solution that is a polymer solution containing a drug; drying the drug solution filling the needle-like recessed portions to form a drug layer containing the drug; supplying a polymer layer forming solution to the mold, the mold provided with a step portion that has a height different from a height of a region in which the needle-like recessed portion is formed in a periphery of the region in which the needle-like recessed portion is formed in a range of equal to or greater than the step portion as seen from above, and then fixing a contact position of the polymer layer forming solution and the mold to the step portion while reducing the polymer layer forming solution; and drying the polymer layer forming solution to form a polymer layer.