The present disclosure relates to a method for manufacturing a microneedle containing a coating part on a needle tip and an apparatus used for the method. When a microneedle is manufactured using the coating method and apparatus according to the present disclosure, a coating part in which a target material is impregnated can be easily inserted into skin and effective dissolution is possible. Further, the target material is allowed to show excellent skin permeability with the dissolution of the coating part of the microneedle manufactured according to the present disclosure, thereby a quantitative amount of target material can be effectively delivered into the skin.

The present disclosure relates to a method for manufacturing a microneedle containing a coating part on a needle tip and an apparatus used for the method. When a microneedle is manufactured using the coating method and apparatus according to the present disclosure, a coating part in which a target material is impregnated can be easily inserted into skin and effective dissolution is possible. Further, the target material is allowed to show excellent skin permeability with the dissolution of the coating part of the microneedle manufactured according to the present disclosure, thereby a quantitative amount of target material can be effectively delivered into the skin.

A molding device including a molding strip formed of a first material and extending along a machine direction, having a width defined along a transverse direction perpendicular to the machine direction, and a thickness measured along a direction perpendicular to the machine direction and to the transverse direction, and an inner face and an outer face, the molding strip including a plurality of cavities, characterized in that part of the cavities are at least partially obturated by a plugging material, so as to define molding cavities for forming retaining elements and/or preforms of retaining elements, and non-functional cavities.

A molding device including a molding strip formed of a first material and extending along a machine direction, having a width defined along a transverse direction perpendicular to the machine direction, and a thickness measured along a direction perpendicular to the machine direction and to the transverse direction, and an inner face and an outer face, the molding strip including a plurality of cavities, characterized in that part of the cavities are at least partially obturated by a plugging material, so as to define molding cavities for forming retaining elements and/or preforms of retaining elements, and non-functional cavities.

According to one implementation, a composite material molding jig 3 includes a tubular member 5 and at least one rigid plate member 6 (6A, 6B) so that a composite material structure O (O1, O2) having a hollow structure can be formed easily. The tubular member 5 has flexibility. The at least one rigid plate member 6 (6A, 6B) reinforces strength of the tubular member 5 partially. The tube is used in a state where air is introduced inside the tube. Further, according to one implementation, a composite material molding method includes using the above-mentioned composite material molding jig 3 in order to produce a composite material structure O (O1, O2) so that the composite material structure O (O1, O2) having a hollow structure can be formed easily.

An apparatus, and a system for manufacturing a bioplastic material from a blend solution of gum arabica (GA) and polyvinyl alcohol (PVA) is provided. The apparatus includes a panel having a first end, a second end distal to the first end, and a plurality of walls extending from a periphery of the panel, the panel configured to accommodate the blend solution. The apparatus further includes a plurality of support members coupled to the first end and the second end of the panel and configured to adjust a slope angle of the panel; and one or more vibration generating units coupled to the plurality of support members and configured to vibrate the panel when the blend solution flows from the first end to the second end of the panel. A method of preparing the bioplastic material is also disclosed.

An apparatus, and a system for manufacturing a bioplastic material from a blend solution of gum arabica (GA) and polyvinyl alcohol (PVA) is provided. The apparatus includes a panel having a first end, a second end distal to the first end, and a plurality of walls extending from a periphery of the panel, the panel configured to accommodate the blend solution. The apparatus further includes a plurality of support members coupled to the first end and the second end of the panel and configured to adjust a slope angle of the panel; and one or more vibration generating units coupled to the plurality of support members and configured to vibrate the panel when the blend solution flows from the first end to the second end of the panel. A method of preparing the bioplastic material is also disclosed.

Provided is a vinyl chloride resin composition that can form a vinyl chloride resin molded product having excellent adhesiveness to a foamed polyurethane molded product. The vinyl chloride resin composition contains a vinyl chloride resin, a plasticizer, and a vinyl chloride-(meth)acrylate copolymer.

The present invention discloses an anti-hair loss and hair growth integrated core-shell microneedle patch, comprising a backing and a core-shell microneedle array attached to one side of the backing, the core-shell microneedle array comprises a plurality of microneedles arranged on the backing to form an array, each microneedle comprises a shell substrate material and an internal core, and the shell substrate material is loaded with nano-enzyme for removing excessive active oxygen. The present invention uses an anti-hair loss and hair growth integrated core-shell microneedle patch of the above mentioned structure, wherein the shell substrate material is rapidly degraded after the microneedle patch is applied to the skin, the nano-enzyme loaded by the shell substrate material can be passively released to remove active oxygen and promote angiogenesis in the microenvironment around hair follicles, the internal core of the microneedle is loaded with mesenchymal stem cell-derived exosomes, and the internal exosomes are released and conveyed to hair follicle niches after the shell substrate material is degraded, so that improvement of pigmentation and promotion of hair regrowth are possible.

The present invention discloses an anti-hair loss and hair growth integrated core-shell microneedle patch, comprising a backing and a core-shell microneedle array attached to one side of the backing, the core-shell microneedle array comprises a plurality of microneedles arranged on the backing to form an array, each microneedle comprises a shell substrate material and an internal core, and the shell substrate material is loaded with nano-enzyme for removing excessive active oxygen. The present invention uses an anti-hair loss and hair growth integrated core-shell microneedle patch of the above mentioned structure, wherein the shell substrate material is rapidly degraded after the microneedle patch is applied to the skin, the nano-enzyme loaded by the shell substrate material can be passively released to remove active oxygen and promote angiogenesis in the microenvironment around hair follicles, the internal core of the microneedle is loaded with mesenchymal stem cell-derived exosomes, and the internal exosomes are released and conveyed to hair follicle niches after the shell substrate material is degraded, so that improvement of pigmentation and promotion of hair regrowth are possible.