A system and method for manufacturing three-dimensional structures is provided. The system includes plurality of printing stations and a robotic unit configured to interact with the plurality of printing stations, each of the plurality of printing stations being arranged to be accessible by the robotic unit. Each printing station includes a station controller for controlling at least one deposition control parameter. The system further includes a system controller configured to operate the robotic unit, and wherein the system controller is communicatively coupled to the plurality of printing stations for controlling at least an execution of printing tasks being performed on the plurality of printing stations. The station controllers are at least partially controllable by means of the system controller, wherein the system controller is configured to adjust at least one deposition control parameter of each printing station independent of deposition control parameters of other printing stations of the plurality of printing stations.

An additive manufacturing apparatus includes a stage configured to hold a component. A radiant energy is device operable to generate and project radiant energy in a patterned image. An actuator is configured to change a position of the stage relative to the radiant energy device. A deposition assembly is upstream of the stage and configured to deposit a resin on a resin support. The deposition assembly includes a reservoir housing configured to retain a volume of resin between the upstream wall and the downstream wall. The deposition assembly also includes an application device operably coupled with the reservoir housing. A computing system is operably coupled with the application device. The computing system is configured to intermittently initiate a flush operation between successive layers of the component, wherein the application device is moved from a first position to a second position during the flush operation.

An additive manufacturing apparatus includes a stage configured to hold a component. A radiant energy is device operable to generate and project radiant energy in a patterned image. An actuator is configured to change a position of the stage relative to the radiant energy device. A deposition assembly is upstream of the stage and configured to deposit a resin on a resin support. The deposition assembly includes a reservoir housing configured to retain a volume of resin between the upstream wall and the downstream wall. The deposition assembly also includes an application device operably coupled with the reservoir housing. A computing system is operably coupled with the application device. The computing system is configured to intermittently initiate a flush operation between successive layers of the component, wherein the application device is moved from a first position to a second position during the flush operation.

A computer-implemented dynamic supporting base creation method that interacts with a three-dimensional (3D) printer that prints an object, the method including providing a physical support, via a first robotic gripper, for an object during three-dimensional (3D) printing using a printing head of the 3D printer and transferring the object to a second robotic gripper to provide a physical support at a different location on the object.

A computer-implemented dynamic supporting base creation method that interacts with a three-dimensional (3D) printer that prints an object, the method including providing a physical support, via a first robotic gripper, for an object during three-dimensional (3D) printing using a printing head of the 3D printer and transferring the object to a second robotic gripper to provide a physical support at a different location on the object.

A build plate supported on a movable carriage of a 3D printing machine includes a plurality of clamping surfaces that are engageable by a mechanical clamping system that includes a plurality of clamp assemblies mounted on the movable carriage. Each of the clamp assemblies is associated with a corresponding clamping surface and includes a clamping arm configured to rotate and translate to selectively engage the corresponding clamping surface, a follower arm configured to rotate, and a conversion mechanism configured to convert rotation of the follower arm to rotation and translation of the clamping arm. An actuation mechanism includes an actuation face, corresponding to each follower arm. The actuation mechanism is arranged to simultaneously exert a force against the follower arm of each of the clamp assemblies to rotate the follower arm as the carriage moves from a working station to an unloading station of the 3D printing machine. The conversion mechanism then converts the rotation of the follower arm of each clamping assembly to rotation and translation of the respective clamping arm to selectively and simultaneously engage and disengage the clamping surfaces of the build plate.

A build plate supported on a movable carriage of a 3D printing machine includes a plurality of clamping surfaces that are engageable by a mechanical clamping system that includes a plurality of clamp assemblies mounted on the movable carriage. Each of the clamp assemblies is associated with a corresponding clamping surface and includes a clamping arm configured to rotate and translate to selectively engage the corresponding clamping surface, a follower arm configured to rotate, and a conversion mechanism configured to convert rotation of the follower arm to rotation and translation of the clamping arm. An actuation mechanism includes an actuation face, corresponding to each follower arm. The actuation mechanism is arranged to simultaneously exert a force against the follower arm of each of the clamp assemblies to rotate the follower arm as the carriage moves from a working station to an unloading station of the 3D printing machine. The conversion mechanism then converts the rotation of the follower arm of each clamping assembly to rotation and translation of the respective clamping arm to selectively and simultaneously engage and disengage the clamping surfaces of the build plate.

Described herein are bioprinters comprising: one or more printer heads, wherein a printer head comprises a means for receiving and holding at least one cartridge, and wherein said cartridge comprises contents selected from one or more of: bio-ink and support material; a means for calibrating the position of at least one cartridge; and a means for dispensing the contents of at least one cartridge. Further described herein are methods for fabricating a tissue construct, comprising: a computer module receiving input of a visual representation of a desired tissue construct; a computer module generating a series of commands, wherein the commands are based on the visual representation and are readable by a bioprinter; a computer module providing the series of commands to a bioprinter; and the bioprinter depositing bio-ink and support material according to the commands to form a construct with a defined geometry.

Described herein are bioprinters comprising: one or more printer heads, wherein a printer head comprises a means for receiving and holding at least one cartridge, and wherein said cartridge comprises contents selected from one or more of: bio-ink and support material; a means for calibrating the position of at least one cartridge; and a means for dispensing the contents of at least one cartridge. Further described herein are methods for fabricating a tissue construct, comprising: a computer module receiving input of a visual representation of a desired tissue construct; a computer module generating a series of commands, wherein the commands are based on the visual representation and are readable by a bioprinter; a computer module providing the series of commands to a bioprinter; and the bioprinter depositing bio-ink and support material according to the commands to form a construct with a defined geometry.

An additive manufacturing (AM) system includes a housing defining a chamber and a build platform disposed in a lower portion of the chamber. The AM system includes an upper gas inlet disposed in a side-wall and in an upper portion of the chamber and configured to supply an upper gas flow parallel to the build platform. The AM system includes a lower gas inlet in the lower portion of the chamber, wherein the lower gas inlet includes one or more pairs of dividing walls extending from the side-wall toward the build platform and configured to guide the lower gas flow at one or more flow angles with respect to the build platform. The AM system includes at least one gas delivery mechanisms to regulate flow characteristics of the upper and lower gas flows, and includes a gas outlet to discharge the upper and lower gas flows from the chamber.