A biomedical device is disclosed. The biomedical device includes a polymerization product of a biomedical device-forming mixture containing (a) one or more grafted glycosaminoglycan polymers including a glycosaminoglycan having a polymer backbone and one or more side chains comprising an ethylenically unsaturated reactive-containing residue grafted onto the polymer backbone, and (b) one or more non-silicone biomedical device-forming monomers.

Various embodiments of the present invention provide systems, methods, and processes for constructing a contact lens. In one embodiment, a contact lens assembly is provided, comprising: a curved polymer polarizer with an aperture; a lenslet disposed inside the aperture wherein the lenslet enables imaging near objects; and a filter attached to the lenslet. In further embodiments, a method for fabricating a flexible contact lens is provided, comprising: fabricating an element having an extrusion; providing a front concave mold, wherein the front mold has an intrusion to accommodate the extrusion of the optical element; affixing the extrusion of the optical element to the intrusion of the front mold; attaching a back convex mold to the front concave mold, thereby forming a mold cavity; and filling the mold cavity with a pre-polymerized liquid, whereby upon polymerization, the pre-polymerized liquid forms the flexible contact lens and the optical element is partially encapsulated within the lens.

A pulsed laser printing module for a contact lens, comprises a steel mold, a pulsed laser device and a forming case. The steel mold is configured for transferring pigment. The pulsed laser device is configured for transmitting ultrashort laser pulses having pulse time widths less than 10.sup.−9 seconds. The ultrashort laser pulses etch the surface of the steel mold to remove a coating of the steel mold to form an etched layer. The forming case has a lower member and an upper member. The lower member is a concavity, and an inner surface of the lower member is provided with a lower curved surface. The upper member is provided with a protrusion corresponding to the lower member, and an outer surface of the protrusion is provided with an upper curved surface corresponding to the lower curved surface. The protrusion is capable of being placed in a concavity of the lower member to form a gap between the lower curved surface and the upper curved surface.

A method of measuring an axis angle of a toric contact lens including a posterior toric central zone having a cylindrical axis, and an anterior lens surface forming a ballast that has an axis of orientation offset from the cylindrical axis at a selected rotational angle is disclosed. The method involves (a) providing anterior and posterior mold sections including respective anterior and posterior mold cavity defining surfaces, wherein the posterior mold cavity defining surface includes a toric central zone and the anterior mold cavity defining surface is shaped to provide the ballast, the mold sections being alignable at multiple rotational positions; (b) providing a detectable feature on each of the anterior and posterior mold sections at a predetermined angular location with respect to the tonic and ballast axes thereof, respectively; (c) rotating the detectable feature of the posterior mold section relative to the detectable feature of the anterior mold section, wherein the detectable feature of the anterior mold section is a zero reference; and (d) measuring the axis angle between the detectable feature of the posterior mold section relative to the detectable feature of the anterior mold section after rotational displacement of the mold sections during toric contact lens formation.

Methods and apparatus for positioning a structure on a polymer layer are described. A method may involve forming a first polymer layer. The method may further involve positioning, by an apparatus, a structure on the first polymer layer, where the apparatus comprises a rod having a first end that supports the structure as the structure is being positioned and a plunger located around the first end of the rod that presses the structure onto the first polymer layer as the structure is being positioned. And the method may involve forming a second polymer layer over the first polymer layer and the structure, where the first polymer layer defines a first side of a body-mountable device and the second polymer layer defines a second side of the body-mountable device opposite the first side.

The invention provides a method for producing photochromic silicone hydrogel (SiHy) contact lenses based on thermal cast-molding technology in a relatively efficient and consistent manner. The method is characterized by selecting a high radical-reactive hydrophilic acrylic monomer while eliminating any low radical-reactive hydrophilic N-vinyl amide monomer in a lens formulation (polymerizable composition), by selecting a weight ratio of low-radical-reactive hydrophilic N-vinyl amide monomer to a high radical-reactive hydrophilic acrylic monomer in a lens formulation if the low radical-reactive hydrophilic N-vinyl amide monomer is needed, and/or by using a relatively high temperature thermal initiator in a lens formulation, to control the lens properties (e.g., water content, elastic modulus, etc.) and lens processability (capability of dry-delensing from molds) of thermally cast-molded SiHy contact lenses while minimizing loss in photochromic ability of resultant SiHy contact lenses.

Systems and methods for optimizing laser damage threshold and induced phase change range in a method of writing phase change structures in a hydrogel material with a femtosecond laser writing system focusing a laser beam into the hydrogel material. laser pulse width and a laser effective NA are selected for a given focused laser average power range to increase the laser damage threshold relative to use of laser pulse widths shorter than the selected laser pulse width and/or use of laser effective NAs greater than the selected laser effective NA. In a particular embodiment, the focused laser average power is from 1 to 5000 mW, the selected laser pulse width is greater than about 165 fs, and the selected laser effective NA is less than 0.50. Applications of the techniques described include laser induced refractive index change (LIRIC) customization of contact lenses, intra-ocular lenses, and other ophthalmic materials.

The present invention generally relates to a method for applying a coating of hydrophilic polymers onto polyvinylalcohol-based hydrogel contact lenses to improve lubricity. In particular, the present invention is directed to a method for forming a coating on a contact lens, preferably a polyvinylalcohol-based hydrogel contact lens, directly in the primary package and maintaining the coated contact lens within said primary package until insertion of the coated contact lens in the eye of the contact lens user. The resultant polyvinylalcohol-based hydrogel contact lens has a coating with improved lubricity and good durability and also can be used directly from the lens package by a patient without washing and/or rinsing.

A method of producing a medical device having a substrate and a hydrophilic polymer layer, including the steps of: pretreating the substrate by placing the substrate in an alkali solution and heating the substrate at a temperature ranging from 50° C. to 100° C.; and heating a solution containing the pretreated substrate, a hydrophilic polymer having an acidic group and a hydroxyalkyl group, and an organic acid at a temperature ranging from 50° C. to 100° C. Provided is a simple method of producing a medical device imparted with hydrophilicity excellent in durability.

The invention is directed to a colored cosmetic photochromic contact lens, comprising: a pupil section, a generally annular iris section surrounding the pupil section, wherein at least the pupil section is photochromic, wherein the iris section having a colored, printed, opaque, intermittent pattern, wherein the said pattern is covered by a clear ink layer, wherein the clear ink layer is on outer surface of lens to the observer.