A dental appliance for positioning a patient's teeth includes a removable orthodontic tooth positioning appliance having teeth receiving cavities shaped to directly receive at least some of the patient's teeth and apply a resilient positioning force to the patient's teeth. The appliance includes a hard polymer layer having a hard polymer layer elastic modulus disposed between a first soft polymer layer having a first soft polymer layer elastic modulus and a second soft polymer layer having a second soft polymer layer elastic modulus. The hard polymer layer elastic modulus is greater than each of the first soft polymer layer elastic modulus and the second soft polymer layer elastic modulus. At least one of the first soft polymer layer and the second soft polymer layer has a flexural modulus of greater than about 35,000 psi.

A dressing for treating tissue with negative pressure is provided herein comprising a composite of dressing layers, including a release film, a perforated coated polymer film, a manifold, and an adhesive cover. Additionally, a method of manufacturing the dressing may comprise applying a cross-linkable polymer to a polymer film, curing the cross-linkable polymer to a gel layer to form a coated polymer film, and perforating the coated polymer film to form fluid restrictions, such as slits and/or slots, though the coated polymer film.

Injection molded articles and methods of making injection molded articles. The methods include the use of a first plasticizing unit and a second plasticizing unit on a common frame feeding a first mold and a second mold on the common frame. Separating the production of each part of a two-part article into separate plasticizers and molds allows for the tuning of production parameters on a per-part basis, improving part flatness and part-to-part weight variance.

A staple cartridge assembly for use with a surgical stapling instrument includes a staple cartridge including a plurality of staples and a cartridge deck. The staple cartridge assembly also includes a compressible adjunct positionable against the cartridge deck, wherein the staples are deployable into tissue captured against the compressible adjunct, and wherein the compressible adjunct comprises a first biocompatible layer comprising a first portion, a second biocompatible layer comprising a second portion, and crossed spacer fibers extending between the first portion and the second portion.

A flexible sheet for neurostimulation has a flexible non-conductive substrate matrix in which electrodes are embedded along a lower surface. Electrically conductive wires extend from the electrodes through the flexible substrate to another exterior surface of the substrate. Methods of making the flexible sheet and making a device using the flexible sheet are also disclosed.

A lid of molded plastic construction, includes a lid body and a cap attached to the lid body by a tether. The tether is substantially continuous with an adjacent peripheral edge of the lid body, with a tear zone between the tether and the adjacent peripheral edge of the lid body formed during molding of the lid. The tear zone is disruptable by application of a tearing pressure to free the tether from the peripheral edge.

Implantable medical constructs formed by winding using winding support structures that can be flexible and can be integrated into the medical construct with biocompatible fiber(s) and/or yarn(s) and at least one continuous length collagen fiber. The implantable medical construct can include open suture anchor apertures formed using posts during a winding sequence.

This invention relates to a method for manufacturing an individualized immobilization element for the non-invasive immobilization and/or mobilization of at least a segment of a body part of a patient in a predetermined position relative to a reference and/or in a pre-certain configuration. The method comprises the steps of (i) providing a data set that comprises a three-dimensional image of an outer contour of at least a part of the segment of the body part to be immobilized and/or mobilized and (ii) the manufacture of at least a part of the immobilization element by rapid manufacturing of a shape on the basis of said data set using a polymeric material containing a thermoplastic polymer having a melting point less than or equal to 100° C., wherein the polymer material contains a nucleating agent for enhancing the of the crystallization of the thermoplastic polymer.

The invention is describing an intrauterine delivery system comprising non-steroidal anti-inflammatory (NSAID) and a progestogenic compound, containing anti-inflammatory active compound in the frame material and that the progestogenic compound is contained in a silicon based reservoir attached to the frame, wherein the frame consist of a thermoplastic material. A further object of the invention is to fabricate drug-containing T-intrauterine systems (I US) with the drug incorporated within the entire backbone of the medical device by using 3D printing technique, based on fused deposition modelling (FDM™). Indomethacin was used to prepare drug-loaded poly-caprolactone (PCL)-based filaments with different drug contents 5-40 wt %, namely 5%, 15% and 30% wt %: of Indomethacin.

A device for sealing sample tubes comprises a tool assembly configured to interface with a rack (10) holding a plurality of sample storage tubes (20), the tool assembly holding a plurality of punches (322) and a die plate (324) including a plurality of cutting holes, with each of the plurality of cutting holes accepting one of the plurality of punches (322). The tool assembly receives a foil sheet (131) between the punches (322) and the die plate (324). The device includes an actuator enabling linear movement of the tool assembly. Linear movement of the tool assembly towards the rack (10) engages the die plate (324) against the rack (10) and punches the punches (322) through the cutting holes of the die plate (324) to punch a plurality of sealing sections from the foil sheet (131) and to press and seal each of the sealing sections against a top end of each of the plurality of sample storage tubes (20) in the rack (10).