An ink-based digital printing system for variable data lithographic printing includes an imaging member having a surface configured to absorb dampening fluid. A dampening fluid patterning system jets dampening fluid onto the imaging member surface according to image data to form a dampening fluid pattern. The system includes a transfer member that receives the jetted dampening fluid pattern from the imaging member at a dampening fluid loading nip for subsequent inking of the dampening fluid pattern to form an ink pattern. The ink pattern is transferred to a substrate from the transfer member at an ink pattern transfer nip.