An inventive drug product filling device for filling a liquid drug product into containers is disclosed. The drug filling device includes a drug product preparer configured for preparing the liquid drug product and a filling station configured for filling the liquid drug product into the containers. The filling station is fluidly coupled to the drug product preparer. A degasser is fluidly interposed between the drug product preparer and the filling station. The degasser has a membrane configured for at least partially separating off gas from the liquid drug product. Methods of (i) filling a liquid drug product into containers, (ii) increasing the accuracy of the filling weight of a liquid drug product in a container, (iii) increasing the stability oxygen-sensitive active pharmaceutical ingredient in a liquid drug product, and (iv) reducing polysorbate aggregate formation in a liquid drug product are also disclosed.

An inventive drug product filling device for filling a liquid drug product into containers is disclosed. The drug filling device includes a drug product preparer configured for preparing the liquid drug product and a filling station configured for filling the liquid drug product into the containers. The filling station is fluidly coupled to the drug product preparer. A degasser is fluidly interposed between the drug product preparer and the filling station. The degasser has a membrane configured for at least partially separating off gas from the liquid drug product. Methods of (i) filling a liquid drug product into containers, (ii) increasing the accuracy of the filling weight of a liquid drug product in a container, (iii) increasing the stability oxygen-sensitive active pharmaceutical ingredient in a liquid drug product, and (iv) reducing polysorbate aggregate formation in a liquid drug product are also disclosed.

The present invention relates to a filler machine and method. The filler machine and method allow efficient and/or accurate filling of containers such as bottles, and have particular application to filling bottles or similar containers with carbonated beverages.

The present invention relates to a filler machine and method. The filler machine and method allow efficient and/or accurate filling of containers such as bottles, and have particular application to filling bottles or similar containers with carbonated beverages.

Methods and systems for simultaneously forming and filling a container from a preform with fluid, adjusting a fill point of the fluid, and removing air and/or foam from within the container. One of the methods includes injecting fluid from a fill source into the preform through a nozzle passage defined between the nozzle and a seal pin of the forming and filling system to simultaneously form the container from the preform and fill the container. After the container is formed and filled, the seal pin is actuated to close the nozzle passage and prevent fluid and air from exiting the container through the nozzle passage, thereby trapping fluid and air within the container under pressure. Air, fluid, and/or foam is extracted out from within the container through a passageway defined within a stretch rod to adjust a fill point of the container.

Method and device for producing containers which are filled with a liquid filling substance from parisons made from a thermoplastic material, wherein the respective parison is at least conditioned thermally and is subsequently shaped into the container during a shaping and filling phase in a mould by way of at least one liquid filling substance as pressure medium, and wherein, while it is being shaped into the container, the prison is preferably guided at least temporarily through a stretching rod and is stretched in the axial direction.

The present invention relates to a filler machine and method. The filler machine and method allow efficient and/or accurate filling of containers such as bottles, and have particular application to filling bottles or similar containers with carbonated beverages.

The present invention relates to a filler machine and method. The filler machine and method allow efficient and/or accurate filling of containers such as bottles, and have particular application to filling bottles or similar containers with carbonated beverages.

A container-filling method includes executing a learning phase by starting a filling operation with a filling parameter that was used to start filling of a another product. The learning phase includes the filling element and saving relationships between a filling parameter, such as expected filling time or foam formation, and a value indicative of that filling parameter. The method includes comparing a saved target with this value to see a termination criterion has been achieved. If not, the filling parameter is varied in response to instructions provided by a simulator and the process repeated.

A container-filling method includes executing a learning phase by starting a filling operation with a filling parameter that was used to start filling of a another product. The learning phase includes the filling element and saving relationships between a filling parameter, such as expected filling time or foam formation, and a value indicative of that filling parameter. The method includes comparing a saved target with this value to see a termination criterion has been achieved. If not, the filling parameter is varied in response to instructions provided by a simulator and the process repeated.