A fluid filling apparatus for filling containers with a fluid is provided. An ultrasonic frequency is used to vibrate a filling nozzle between successive container filling cycles. The vibrations break a liquid string filament formed at a discharge end of the filling nozzle at the end of each filling cycle. Methods and a fluid filling nozzle for filling containers with a fluid are also provided.

A fluid filling apparatus for filling containers with a fluid is provided. An ultrasonic frequency is used to vibrate a filling nozzle between successive container filling cycles. The vibrations break a liquid string filament formed at a discharge end of the filling nozzle at the end of each filling cycle. Methods and a fluid filling nozzle for filling containers with a fluid are also provided.

A method for producing sterile solution product bags includes positioning a manifold assembly onto a filling machine. The manifold assembly includes a plurality of bags, a first filter, and a connection line in fluid communication with the first filter. Each of the plurality of bags includes a bladder and a stem in fluid communication with the bladder and with the connection line. The method includes activating a pump and at least partially filling one or more of the bladders by pumping fluid through the feed line, the first filter, and the connection line. The method includes sealing the stem of each of the filled product bags at a location between the connection line and the bladder, thereby creating one or more at least partially filled and sealed product bags. The method includes separating each of the at least partially filled and sealed product bags from the connection line.

Embodiments include piston filling apparatuses having first and second piston pumps in fluid communication with supply reservoirs. The first and second piston pumps can each draw in a volume of fluid and simultaneously expel a volume of fluid. Fluid expelled by the first and second piston pumps can be mixed in a manifold and allowed to flow through a filler nozzle by a filler valve. Other embodiments are also included herein.

Embodiments include piston filling apparatuses having first and second piston pumps in fluid communication with supply reservoirs. The first and second piston pumps can each draw in a volume of fluid and simultaneously expel a volume of fluid. Fluid expelled by the first and second piston pumps can be mixed in a manifold and allowed to flow through a filler nozzle by a filler valve. Other embodiments are also included herein.

The present invention provides a filling nozzle obtained by using a resin selected from a cycloolefin polymer and a cycloolefin copolymer, or a filling nozzle including a tubular passage for supplying a pharmaceutical solution, and a filling port disposed at a lower end of the tubular passage, in which the tubular passage and the filling port have a circular peripheral cross-section, and an inner diameter of the passage of the filling port is larger than an inner diameter of the tubular passage disposed on an upstream side.

A guide member including: an upper main body that is positioned so as to enclose the filling valve and so as to be movable in a vertical direction relative to the filling port; and a lower main body that is positioned so as to enclose the upper main body and is configured to be slidable on the surface of the upper main body. The lower main body is provided with an abutting portion that protrudes inward relative to the inner surface of the lower main body and that is configured to abut against at least an opening portion of the container mounted on the container supporting unit, and the guide member is configured to allow the container to be lifted while keeping the abutting portion abutted against the opening portion, thereby guiding the opening portion to an appropriate position relative to the filling port.

A guide member including: an upper main body that is positioned so as to enclose the filling valve and so as to be movable in a vertical direction relative to the filling port; and a lower main body that is positioned so as to enclose the upper main body and is configured to be slidable on the surface of the upper main body. The lower main body is provided with an abutting portion that protrudes inward relative to the inner surface of the lower main body and that is configured to abut against at least an opening portion of the container mounted on the container supporting unit, and the guide member is configured to allow the container to be lifted while keeping the abutting portion abutted against the opening portion, thereby guiding the opening portion to an appropriate position relative to the filling port.

A method of dispensing fluid includes dispensing a first quantity of fluid so that fluid flows through a manifold port assembly and into a first container, the manifold port assembly includes a housing having an inlet port and a plurality of outlet ports formed thereon; and a carousel bounding a plurality of fluid paths that each extend between a first end and an opposing second end, the carousel being rotatably disposed within the housing so that when the first end of each one of the plurality of fluid paths is aligned with the inlet port on the housing, the second end of the corresponding one of the plurality of fluid paths is aligned with one of the plurality of outlet ports. A motor is activated to rotate the carousel of the manifold port assembly to a second position. A second quantity of fluid is dispensed so that fluid flows through the manifold port assembly and into a second container.

A method of dispensing fluid includes dispensing a first quantity of fluid so that fluid flows through a manifold port assembly and into a first container, the manifold port assembly includes a housing having an inlet port and a plurality of outlet ports formed thereon; and a carousel bounding a plurality of fluid paths that each extend between a first end and an opposing second end, the carousel being rotatably disposed within the housing so that when the first end of each one of the plurality of fluid paths is aligned with the inlet port on the housing, the second end of the corresponding one of the plurality of fluid paths is aligned with one of the plurality of outlet ports. A motor is activated to rotate the carousel of the manifold port assembly to a second position. A second quantity of fluid is dispensed so that fluid flows through the manifold port assembly and into a second container.