A device for treating containers, for example, for filling and closing containers in filling plants is described. The device includes an isolator chamber in which the treatment of the containers takes place, and an outlet disposed beneath the isolator chamber for discharging fluids, wherein the outlet has a housing for receiving ejected containers and a suction device for extracting gases from the isolator chamber.

One embodiment of the present invention provides an apparatus for processing sealed plastic containers having a first headspace pressure. The apparatus may include: an open entry port or tunnel for continuously receiving containers; a sanitizer configured to sanitize outside surfaces of the received containers; a perforator configured to perforate or open a cap or seal of the containers within the apparatus; a sealer configured to seal the perforation or opening formed in the cap or seal of the containers; an open exit port of tunnel for continuously exiting the processed containers; and a conveyor system configured to transporting or convey the containers from the open entry port or tunnel, through and within the apparatus, to the open exit port or tunnel and away from the sanitized environment of the apparatus. The apparatus may be further configured to maintain a sanitized environment within the apparatus, perforator, and/or sealer.

An isolator system for filling a container with a liquid, the isolator system comprises a filling module having a filling station for filling the container with the liquid, a stopper placing station for placing a stopper on the filled container, and a plurality of handling devices for handling the container within the filling module; a first transfer station for transferring the container to be filled into the filling module; a second transfer station for transferring the filled container out of the filling module; and a control device. The present application also discloses a transfer station for transferring a container and several methods.

In one general aspect, a method for filling multiple containers with a pharmaceutical product is disclosed, which comprises decontaminating sealed nested materials in a transfer chamber, removing from the sealed nested materials one or both of a container nest holding the multiple containers and a closure nest holding multiple closures, transferring from the transfer chamber to a controlled environment enclosure the removed nest, aseptically filling the containers with the pharmaceutical product, and closing the containers with the multiple closures. The nests are configured to allow multiple closures and containers to be simultaneously aligned concentrically, and closed simultaneously. Spring-loaded retaining structures on the closure nest allow it to releasably retain multiple closures above the corresponding multiple containers. In some embodiments the spring-loaded features are monolithically integrated with the closure nest. The product may be lyophilized in partially sealed containers while the sealing closures are releasably retained by the closure nest.

The invention relates to a sealed container (1) comprising a flange (5, 6) that delimits a through-passage having an axial axis in the container, a door (7) movably mounted on the flange (5, 6), and a first annular seal (13) located between the flange (5, 6) and the door (7), the flange, the door and the first seal forming a sealed connection device that can be connected to a complementary connection device on a sterile enclosure by bayonet connection means in order to allow sterile communication between the sealed container and the sterile enclosure, characterized in that the container (1) includes a protective cover (20) on the connection device, said protective cover being forcibly clipped onto the container, and in that the container further includes contact pressure means arranged between the protective cover (20) and the connection device so as to apply contact pressure to the connection device in the axial direction proportional to the clipping force.

The present invention relates to a system for the disinfection of containers in a blowing and filling system of the containers with a product, in particular a system for the internal disinfection of the containers by means of ultraviolet-C radiation LED emitters.

A container lid is provided herein having structurally reinforcing ribs therein. The ribs increase the strength of the lid across a central region thereof. Specifically, the lid can have an outer perimeter and the ribs can be spaced inwardly from the outer perimeter. The inwardly spaced ribs can provide a distinct look for consumer differentiation. Additionally, the ribs can be arcuate so that they generally follow a curvature of the outer perimeter of the lid. As such, a label region within the lid central region is preserved, while the lid is still strengthened by the ribs.

Systems and methods for aseptically filling pharmaceutical containers with pharmaceutical fluid are disclosed. In one general aspect, these are based on an aseptically sealable chamber that includes a transfer wall to which pre-sealed pharmaceutical source and receiving containers are mounted aseptically. A robotic arm and a syringe store are disposed within the chamber along with a sterilizing facility for establishing in the chamber an aseptic condition. The robotic arm can grip and operate syringes to inject and/or extract pharmaceutical products from the containers by piercing their closures with the needles of the syringes.

A device for closing a chamber of a container having an opening for accessing the chamber comprises a plunger, a plunger seat, a container carrier and a spacer. The plunger seat releasably holds the plunger in a predefined alignment. The container carrier is arranged to be connected to the container in a predefined position and alignment in relation to the opening of the container. The spacer is arranged to position and align the plunger seat adjacent to and distant from the container carrier such that the opening of the container is open when the container is connected to the container carrier.

A trouble recovering method of an aseptic filling machine and an aseptic filling machine which can resume operation at an early stage if a trouble occurs in any of portions during an operation of the aseptic filling machine are provided. A door of a chamber in which the trouble occurred is opened while a pressure in the chamber other than the chamber in which the trouble occurred is kept positive, the trouble is removed and then, the door is closed, an inside of the chamber in which the trouble occurred is cleaned as necessary, the inside of the chamber is sterilized and then, the operation of the aseptic filling machine is resumed.