Method for filling a sterile container, in particular a bottle, with a liquid, wherein a sterile connection is established between a flexible bag and a first opening of the container, a sterile connection is established between a second opening of the container and a source of the liquid to be filled into the container, the liquid is filled into the container, a gas, in particular air, which is present in the container is displaced by the liquid and forced into the flexible bag while increasing the volume of the flexible bag and the connection between the source of liquid and the second opening of the container is severed in a sterile way.

In aspects of bi-directional packaging adhesive, a sterile package includes an adhesive patch that adheres to an applied surface. The sterile package includes a non-stick backing that adheres to the adhesive patch, with the non-stick backing being removable for application of the adhesive patch. The sterile package includes packaging that encompasses the adhesive patch and the non-stick backing, and includes a bi-directional adhesive configured to release in a first package opening direction to remove the packaging while maintaining the adherence of the non-stick backing to the adhesive patch, and hold in a second package opening direction to remove the non-stick backing from the adhesive patch along with removing the packaging. A portion of the non-stick backing is attached to an inside of the packaging with the bi-directional adhesive, and the attached portion peels the non-stick backing from the adhesive patch in the second package opening direction to open the packaging.

System for providing marked containers comprising a computerised control system storing at least one unique identifier for each container, to be applied to a respective container, a printing unit comprising an ink delivery station, operatively connected with said computerised control system, able to print said identifier on each container, comprising a printing head filled with ink and having a plurality of nozzles configured for spraying said ink on an external surface of each container, displacement means able to perform a relative rotation, translation or rotary translation between each container and the printing head during the printing of the identifier on the container, said displacement means being operatively connected with said computerised control system.

System for providing marked containers comprising a computerised control system storing at least one unique identifier for each container, to be applied to a respective container, a printing unit comprising an ink delivery station, operatively connected with said computerised control system, able to print said identifier on each container, comprising a printing head filled with ink and having a plurality of nozzles configured for spraying said ink on an external surface of each container, displacement means able to perform a relative rotation, translation or rotary translation between each container and the printing head during the printing of the identifier on the container, said displacement means being operatively connected with said computerised control system.

In one general aspect, a method for filling multiple containers with a pharmaceutical product is disclosed, which comprises decontaminating sealed nested materials in a transfer chamber, removing from the sealed nested materials one or both of a container nest holding the multiple containers and a closure nest holding multiple closures, transferring from the transfer chamber to a controlled environment enclosure the removed nest, aseptically filling the containers with the pharmaceutical product, and closing the containers with the multiple closures. The nests are configured to allow multiple closures and containers to be simultaneously aligned concentrically, and closed simultaneously. Spring-loaded retaining structures on the closure nest allow it to releasably retain multiple closures above the corresponding multiple containers. In some embodiments the spring-loaded features are monolithically integrated with the closure nest. The product may be lyophilized in partially sealed containers while the sealing closures are releasably retained by the closure nest.

A continuous decontamination device capable of achieving short-term operations to provide uniform decontamination levels at each part by employing decontamination agents such as hydrogen peroxide without using expensive electron accelerators and of treating articles to be decontaminated in large quantities.

The device includes a device body composed of a decontamination region and an aeration region, a conveyance means configured to convey an article, a mist supply means, and an aeration means. The conveyance means changes a part for supporting the article inside the decontamination region when the conveyance means supports the article carried from an inlet and conveys the article to an outlet, thereby decontaminating all external surfaces of the article. The mist supply means includes an ultrasonic atomizer configured to convert a decontamination agent into a decontamination agent mist to concentrate the decontamination agent mist on external surfaces of the article conveyed inside the decontamination region. The aeration means removes with clean gas a residue of the decontamination agent mist on the external surfaces of the article.

An apparatus is configured to make containers from sheet material. The apparatus includes a supply station for supplying a film having at least one folded portion having three or more film flaps folded and superimposed with respect to each other; a welding station configured to receive the film. The welding station comprises a welding head configured for welding the folded portion of the film and forming a container defining a housing compartment; the welding head comprises a heater made of electrically conductive material whose electrical resistivity, at least in a predetermined temperature range, decreases upon the increase of the temperature of the same electrically conductive material.

An apparatus is configured to make containers from sheet material. The apparatus includes a supply station for supplying a film having at least one folded portion having three or more film flaps folded and superimposed with respect to each other; a welding station configured to receive the film. The welding station comprises a welding head configured for welding the folded portion of the film and forming a container defining a housing compartment; the welding head comprises a heater made of electrically conductive material whose electrical resistivity, at least in a predetermined temperature range, decreases upon the increase of the temperature of the same electrically conductive material.

A packaging system for the storage of an ophthalmic device is disclosed. The packaging system includes a sealed container containing one or more unused ophthalmic devices immersed in an aqueous packaging solution that includes ectoine or an ophthalmologically acceptable ectoine derivative. The aqueous packaging solution has an osmolality of at least about 150 mOsm/kg, a pH of about 6 to about 9 and is sterilized.

A packaging system for the storage of an ophthalmic device is disclosed. The packaging system includes a sealed container containing one or more unused ophthalmic devices immersed in an aqueous packaging solution that includes ectoine or an ophthalmologically acceptable ectoine derivative. The aqueous packaging solution has an osmolality of at least about 150 mOsm/kg, a pH of about 6 to about 9 and is sterilized.