Systems and methods are disclosed for sterile delivery of prostheses that protect refined and/or conditioned surface properties and thereby reduce aging of surface properties in prostheses. An example of the system includes a partially custom-shaped holder that also serves as an insertion tool that holds a customized dental prosthesis in a pre-defined position inside a titanium container that is hermetically sealed. Container materials serve as a getter or catalyst with respect to the osseoconductive surface. An example of the method includes laser welding to hermetically seal a metal container as packaging for a prosthesis with a metal foil, and the sterilization of the packaged and sealed prosthesis with dry heat.

Systems and methods for filling and sealing a container can include a housing having an opening for receiving containers, a rotary assembly including mount assemblies disposed in the housing, the rotary assembly operable to rotate the of mount assemblies about a central axis, a washing station, a filling station, a steam injector, and cap setter disposed in the housing.

A sterilization method includes a circulation step of circulating a sterilizer through a circulation line (53) while the sterilizer is being heated by a heater (H), and a sterilization step of sterilizing a filling chamber (42) by supplying, to the filling chamber (42), the sterilizer heated by the heater (H).

A system for the sterile filling of containers for pharmaceutical products, which includes a device for sterilizing containers and a machine for filling sterilized containers, wherein the device for sterilizing containers includes at least one autoclave, and wherein the system includes an automated container-accumulation device and means for automatically transporting the containers sterilized in the autoclave from said autoclave to the container-filling machine via said container-accumulation device.

A system for the sterile filling of containers for pharmaceutical products, which includes a device for sterilizing containers and a machine for filling sterilized containers, wherein the device for sterilizing containers includes at least one autoclave, and wherein the system includes an automated container-accumulation device and means for automatically transporting the containers sterilized in the autoclave from said autoclave to the container-filling machine via said container-accumulation device.

Systems and methods for filling and sealing a container can include a housing having an opening for receiving containers, a rotary assembly including mount assemblies disposed in the housing, the rotary assembly operable to rotate the of mount assemblies about a central axis, a washing station, a filling station, a steam injector, and cap setter disposed in the housing.

An aseptic filling machine capable of performing molding and filling at the same time that has a compact facility size, requires a reduced initial investment, requires a reduced running cost because of its simplified process, and ensures an aseptic condition with reliability, and an aseptic filling method therefor. An aseptic filling machine includes a pre-heating sterilizing portion that sterilizes a preform, a heating portion that heats the sterilized preform, a molding and filling portion that fills the heated preform with a sterilized content under high pressure, thereby molding the preform into a bottle and at the same time filling the preform with the content, and a sealing portion that seals the bottle filled with the content. Before the aseptic filling machine starts operating, each portion is sterilized. During operation of the aseptic filling machine, aseptic air is supplied to each portion to maintain the aseptic condition.

An automated, unmanned continuous system (200) for packaging flowable food products at elevated temperatures and pressures includes an upstream thermal processing station (202) to heat the food products and direct the heated food products to a pressurized unmanned filling station (204), whereat containers (242) are filled with the heated food products within a pressurized housing (232), and then transported to a pressurized and unmanned sealing station (206) where the containers are sealed with a lid or cover (283) within a pressurized housing (282). Thereafter, the filled and sealed containers (242) are routed from the pressurized housing (282) through a pressurized transfer tube or passageway (208) for further processing at a downstream thermal processing station (210).

In the COP treatment and the SOP treatment of the interior of a chamber of an aseptic filler, any cleaning liquid or aseptic water remaining in the chamber is quickly removed before spray of a sterilizer containing peracetic acid or hydrogen peroxide.

A transfer device for transferring a container in the chamber of the aseptic filler is driven to remove the cleaning liquid sued for the COP treatment or the aseptic water used for the SOP treatment.

A sterilization process is performed on a preform or container made of resin after a corona discharge treatment is performed on an inner surface of the preform or container, the corona discharge treatment including applying a voltage produced in a corona discharge to an electrode that passes through an opening part of the preform or container, an insertion step of inserting the electrode to which the voltage is applied into the preform or container through the opening part, and a bottom part treatment step of treating an inner surface of a bottom part of the preform or container by bringing the electrode close to the bottom part until the corona discharge from the electrode changes discharge mode, and the sterilization process including a hydrogen peroxide supplying step of blasting a mist or gas of hydrogen peroxide solution or a mixture thereof to the preform or container.