A seed fulfillment system is an automated system for sorting and delivering different types of seeds from different seed containers to a shipping-container loading system which loads shipping containers with the seeds. The seed fulfillment system includes an intermediary-container handling system which conveys intermediary containers of seeds from a filling system to a shipping-container loading system.

A device for sealing sample tubes comprises a tool assembly configured to interface with a rack (10) holding a plurality of sample storage tubes (20), the tool assembly holding a plurality of punches (322) and a die plate (324) including a plurality of cutting holes, with each of the plurality of cutting holes accepting one of the plurality of punches (322). The tool assembly receives a foil sheet (131) between the punches (322) and the die plate (324). The device includes an actuator enabling linear movement of the tool assembly. Linear movement of the tool assembly towards the rack (10) engages the die plate (324) against the rack (10) and punches the punches (322) through the cutting holes of the die plate (324) to punch a plurality of sealing sections from the foil sheet (131) and to press and seal each of the sealing sections against a top end of each of the plurality of sample storage tubes (20) in the rack (10).

Provided is packaging machine with a sealing station that includes a mold with an upper tool and a lower tool facing each other and suitable for cooperating with one another in an operative position of the mold, between which there is delimited an inner area. The lower tool includes a cavity that is configured to receive a tray. A gas injection opening is located adjacent to a first side of the cavity and communicated with the inner area. The upper tool includes a sealing tool and an actuator device facing an actuation region of the lower tool defined between the first side of the cavity and a contact location of the upper and lower tools, and being closer to the lower tool than the sealing tool.

A sealed pharmaceutical container includes a shoulder, a neck extending from the shoulder, and a flange extending from the neck. The flange includes an inclined sealing surface defining an opening in the sealed pharmaceutical container. The sealed pharmaceutical container also includes a sealing assembly including a stopper extending over the sealing surface of the flange and a cap securing the stopper to the flange. The stopper has a glass transition temperature (T.sub.g) that is greater than or equal to −70° C. and less than or equal to −45° C. The sealing assembly maintains a helium leakage rate of the sealed pharmaceutical container of less than or equal to 1.4×10.sup.−6 cm.sup.3/s as the sealed pharmaceutical container is cooled to a temperature of less than or equal to −45° C.

An apparatus for cutting off and joining a sheet element to a container includes an operating unit including a cutting device with a cutting edge surrounding a joining device. The operating unit and the container are movable with respect to one another along a movement axis between a spaced condition, in which a sheet material is interposed therebetween and is spaced therefrom, and a joined condition, in which the joining device joins the material to the container. A retaining device retains the material during joining and cutting. In the joined condition, the cutting device remains fixed relative to the joining device and the retaining device moves along the axis from tensioning to cutting positions, the sheet element being cut on the cutting edge from the material during movement of the retaining device from the tensioning to the cutting positions.

An isolator system for filling a container with a liquid, the isolator system comprises a filling module having a filling station for filling the container with the liquid, a stopper placing station for placing a stopper on the filled container, and a plurality of handling devices for handling the container within the filling module; a first transfer station for transferring the container to be filled into the filling module; a second transfer station for transferring the filled container out of the filling module; and a control device. The present application also discloses a transfer station for transferring a container and several methods.

In one general aspect, a method for filling multiple containers with a pharmaceutical product is disclosed, which comprises decontaminating sealed nested materials in a transfer chamber, removing from the sealed nested materials one or both of a container nest holding the multiple containers and a closure nest holding multiple closures, transferring from the transfer chamber to a controlled environment enclosure the removed nest, aseptically filling the containers with the pharmaceutical product, and closing the containers with the multiple closures. The nests are configured to allow multiple closures and containers to be simultaneously aligned concentrically, and closed simultaneously. Spring-loaded retaining structures on the closure nest allow it to releasably retain multiple closures above the corresponding multiple containers. In some embodiments the spring-loaded features are monolithically integrated with the closure nest. The product may be lyophilized in partially sealed containers while the sealing closures are releasably retained by the closure nest.

A feeding unit (12) which is configured to feed articles (3) from a pick-up station (S10) to a delivery station (S11). The feeding unit (12) comprises: a gripping head (16) provided with at least one gripping means (17) and attached to a shaft (13). The shaft (13) is configured to translate along the rotation axis (X) between a lowered position (PA), in which the articles (3) are picked up and released by the gripping head (16), and a raised position (PS), in which the gripping head (16) rotates between the pick-up station (S10) and the delivery station (S11). The feeding unit (12) comprises two actuators (25, 26) which are coaxial to the shaft (13) and which are configured to respectively translate the shaft (13) between the lowered position (PA) and the raised position (PS) along the rotation axis (X) and to rotate the shaft (13) around the rotation axis (X) between the pick-up station (S10) and the delivery station (S11).

A cardboard tray folded from an unfolded sheet of cardboard includes: a bottom wall with a circumferential edge formed out of an even number of straight edges; wall parts each arranged to a straight edge of the bottom wall; and first flange parts alternately arranged to subsequent wall parts along the circumferential edge. The first flange parts include at least a first, a second, and a third elongate flange part section, which are connected parallel and along an elongate edge to each other. The first elongate flange part section is arranged to the respective wall part, the third elongate flange part section is connected parallel and along an elongate edge to the second elongate flange part section, the third elongate flange part section is adhered to the outside of the respective wall part, and the second flange part section is double folded against the first flange part section.

A plural-mode automatic medicament packaging system. In embodiments, the system may include an automatic dispensing machine including an automatic medicament dispensing unit and may further include pouch packaging and blister package packaging units. The medicament dispensing unit may include one or more storage and dispensing units which store and dispense medicaments. Medicaments output from the medicament dispensing unit may be packaged in a pouch package by the pouch packaging unit. Alternatively, a diverter may direct medicaments output from the medicament dispensing unit to the pouch package packaging unit for packaging in a blister package. A single automatic medicament packaging system can package medicaments in different types of packaging providing a pharmacy with the opportunity to package medicaments in the form of packaging most appropriate to meet patient needs.